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Strain Name:
C57BL/6J-MtgxR5259Btlr/Mmmh
Stock Number:
042856-MU
Citation ID:
RRID:MMRRC_042856-MU
Other Names:
R5259 (G1), C57BL/6J-MtgxR5259Btlr
Major Collection:

Strain Information

Bdnf
Name: brain derived neurotrophic factor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12064
HGNC: HGNC:1033
Homologene: 7245
Slc35a1
Name: solute carrier family 35 (CMP-sialic acid transporter), member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24060
Homologene: 38181
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 116871
Homologene: 14282
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kv3.4, Kcr2-4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Rheb
Name: Ras homolog enriched in brain
Synonyms: Rheb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19744
Homologene: 123916
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: D13Wsu64e, Larp5, A130023E24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Ddx18
Name: DEAD box helicase 18
Synonyms: 2310005B10Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66942
HGNC: HGNC:2741
Homologene: 6697
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: T200, B220, CD45, Lyt-4, Ly-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Zfp738
Name: zinc finger protein 738
Synonyms: 6720487G11Rik, 3830402I07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408068
Homologene: 133713
Rbm33
Name: RNA binding motif protein 33
Synonyms: 6430512A10Rik, 3200001K10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: Min, CC1, adenomatosis polyposis coli
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Morc1
Name: microrchidia 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17450
VEGA: 16
HGNC: HGNC:7198
Homologene: 7843
Fam13c
Name: family with sequence similarity 13, member C
Synonyms: C030038O19Rik, 1200015N20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71721
Homologene: 11490
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Vip2, Hisppd1, Cfap160
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227399
Homologene: 49409
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Isx
Name: intestine specific homeobox
Synonyms: 9130012O13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71597
Homologene: 28312
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Dbr, bls, Aim-1, dominant brown, blanc-sale, Aim1, Matp, Oca4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22293
Homologene: 9412
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Prl8a6
Name: prolactin family 8, subfamily a, member 6
Synonyms: Prlpc, PLP-Ca, PLP-calpha, Prlpc1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19112
Ceacam18
Name: CEA cell adhesion molecule 18
Synonyms: 2010110O04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72431
Homologene: 48111
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70083
VEGA: 17
Homologene: 11432
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20623
Homologene: 9797
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Oplah
Name: 5-oxoprolinase (ATP-hydrolysing)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75475
HGNC: HGNC:8149
Homologene: 90938
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Cfap96
Name: cilia and flagella associated protein 96
Synonyms: 1700029J07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69479
Homologene: 45977
Zfp770
Name: zinc finger protein 770
Synonyms: 6430601A21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228491
Homologene: 82354
Abhd18
Name: abhydrolase domain containing 18
Synonyms: 3110057O12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269423
Homologene: 105457
Scamp1
Name: secretory carrier membrane protein 1
Synonyms: 4930505M11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107767
Homologene: 37975
Vmn1r20
Name: vomeronasal 1 receptor 20
Synonyms: Gm5569
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434017
Homologene: 79462
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Baat
Name: bile acid-Coenzyme A: amino acid N-acyltransferase
Synonyms: taurine N-acyltransferase, BAT
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12012
HGNC: HGNC:932
Homologene: 1286
Pnma8b
Name: PNMA family member 8B
Synonyms: EG434128, Pnmal2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434128
Homologene: 35491
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 408191
Homologene: 130042
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Or7e166
Name: olfactory receptor family 7 subfamily E member 166
Synonyms: GA_x6K02T2PVTD-13452606-13453535, MOR146-8P, Olfr857
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257963
Homologene: 134093
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c, CR4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: 4933402B14Rik, Gm6095, 4921529N20Rik, Tmem146
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Or2ak6
Name: olfactory receptor family 2 subfamily AK member 6
Synonyms: GA_x6K02T2NKPP-708319-707399, MOR285-2, Olfr319
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258493
Gdf2
Name: growth differentiation factor 2
Synonyms: Bmp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12165
VEGA: 14
HGNC: HGNC:4217
Homologene: 32299
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Rhebl1
Name: Ras homolog enriched in brain like 1
Synonyms: 1810036J22Rik, Rheb2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69159
Homologene: 5477
Fermt1
Name: fermitin family member 1
Synonyms: Kindlin-1, 5830467P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241639
Homologene: 9773
Nat8
Name: N-acetyltransferase 8 (GCN5-related)
Synonyms: 0610037O16Rik, Cml4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68396
Homologene: 9479
Psmd6
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Synonyms: 2400006A19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66413
HGNC: HGNC:9564
Homologene: 7157
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 111175
Homologene: 69255
Slc35f3
Name: solute carrier family 35, member F3
Synonyms: B230375D17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210027
Homologene: 62481
Adi1
Name: acireductone dioxygenase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104923
Homologene: 75081
Fra10ac1
Name: FRA10A associated CGG repeat 1
Synonyms: 5730455O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70567
VEGA: 19
HGNC: HGNC:1162
Homologene: 13852
Gm815
Name: predicted gene 815
Synonyms: LOC329047
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329047
VEGA: 19
RP24-187P11.4
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm38160
Name: predicted gene, 38160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm15723
Name: predicted gene 15723
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 102633245
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 32,545,517 bp
  • A to G, chromosome 1 at 72,277,285 bp
  • G to T, chromosome 1 at 82,453,893 bp
  • A to G, chromosome 1 at 97,721,208 bp
  • A to G, chromosome 1 at 105,721,376 bp
  • A to G, chromosome 1 at 121,567,789 bp
  • T to A, chromosome 1 at 138,112,255 bp
  • C to T, chromosome 1 at 139,740,495 bp
  • A to G, chromosome 2 at 109,723,982 bp
  • T to A, chromosome 2 at 114,197,193 bp
  • T to C, chromosome 2 at 132,906,765 bp
  • A to C, chromosome 3 at 40,916,890 bp
  • C to T, chromosome 3 at 51,484,612 bp
  • A to G, chromosome 3 at 107,448,085 bp
  • C to T, chromosome 4 at 34,683,322 bp
  • T to A, chromosome 4 at 49,490,070 bp
  • C to T, chromosome 5 at 22,103,397 bp
  • A to C, chromosome 5 at 24,803,745 bp
  • T to A, chromosome 5 at 28,352,774 bp
  • C to T, chromosome 5 at 32,938,291 bp
  • A to T, chromosome 5 at 105,050,979 bp
  • T to C, chromosome 6 at 32,517,021 bp
  • T to A, chromosome 6 at 57,432,065 bp
  • A to T, chromosome 6 at 85,830,891 bp
  • A to G, chromosome 7 at 16,945,274 bp
  • T to C, chromosome 7 at 43,637,112 bp
  • T to A, chromosome 7 at 79,694,723 bp
  • T to A, chromosome 7 at 103,250,574 bp
  • G to A, chromosome 7 at 128,148,278 bp
  • T to A, chromosome 8 at 24,810,834 bp
  • T to C, chromosome 8 at 45,962,336 bp
  • A to G, chromosome 8 at 74,892,845 bp
  • A to T, chromosome 8 at 126,389,133 bp
  • A to G, chromosome 9 at 19,712,813 bp
  • A to T, chromosome 9 at 78,710,152 bp
  • A to G, chromosome 9 at 109,520,312 bp
  • G to C, chromosome 9 at 122,166,320 bp
  • C to G, chromosome 10 at 70,441,063 bp
  • A to T, chromosome 10 at 74,396,372 bp
  • T to C, chromosome 10 at 114,816,817 bp
  • A to G, chromosome 11 at 58,701,952 bp
  • A to C, chromosome 11 at 58,701,953 bp
  • T to C, chromosome 12 at 28,675,545 bp
  • T to A, chromosome 12 at 115,834,177 bp
  • C to T, chromosome 13 at 9,158,184 bp
  • C to T, chromosome 13 at 27,436,196 bp
  • G to T, chromosome 13 at 67,669,686 bp
  • T to G, chromosome 13 at 94,232,086 bp
  • G to A, chromosome 14 at 14,116,602 bp
  • T to C, chromosome 14 at 33,944,831 bp
  • A to G, chromosome 14 at 123,515,651 bp
  • T to C, chromosome 15 at 10,515,150 bp
  • C to T, chromosome 15 at 11,027,785 bp
  • A to T, chromosome 15 at 76,301,210 bp
  • T to A, chromosome 15 at 98,880,583 bp
  • G to A, chromosome 16 at 29,456,610 bp
  • G to A, chromosome 16 at 48,630,769 bp
  • A to T, chromosome 17 at 25,796,540 bp
  • A to C, chromosome 17 at 56,660,235 bp
  • A to G, chromosome 17 at 75,363,362 bp
  • T to A, chromosome 17 at 79,668,017 bp
  • A to G, chromosome 17 at 83,804,574 bp
  • A to C, chromosome 18 at 12,465,508 bp
  • T to C, chromosome 18 at 34,314,290 bp
  • T to A, chromosome 18 at 59,410,246 bp
  • G to A, chromosome 19 at 26,886,406 bp
  • A to G, chromosome 19 at 38,199,662 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5259 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042856-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.