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Strain Name:
C57BL/6J-MtgxR5282Btlr/Mmmh
Stock Number:
042867-MU
Citation ID:
RRID:MMRRC_042867-MU
Other Names:
R5282 (G1), C57BL/6J-MtgxR5282Btlr
Major Collection:

Strain Information

Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 5033417D07Rik, BTF2, D5Ertd679e, 34kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Nub1
Name: negative regulator of ubiquitin-like proteins 1
Synonyms: BS4, NY-REN-18, 4931404D21Rik, 6330412F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53312
Homologene: 41108
Zfp553
Name: zinc finger protein 553
Synonyms: C330013F15Rik, 2600009K23Rik, ENSMUSG00000054461
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233887
Homologene: 27098
Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72515
VEGA: 17
Homologene: 38810
Rrp12
Name: ribosomal RNA processing 12 homolog
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107094
VEGA: 19
Homologene: 22370
Agrn
Name: agrin
Synonyms: NMF380, Agrin, nmf380
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC155, RPC1, 9330175N20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Tbck
Name: TBC1 domain containing kinase
Synonyms: A630047E20Rik, C030007I09Rik, 1700120J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271981
Homologene: 13221
Xpo7
Name: exportin 7
Synonyms: Ranbp16, 4930506C02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Nufip1
Name: nuclear FMR1 interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27275
VEGA: 14
HGNC: HGNC:8057
Homologene: 8216
Cep128
Name: centrosomal protein 128
Synonyms: 5430424K18Rik, 4930534B04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75216
Homologene: 35315
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241520
Homologene: 18462
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21872
Homologene: 2445
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69944
Homologene: 138400
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 3110031A07Rik, 2410140K03Rik, D5Ertd591e, A630018G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Pard6g
Name: par-6 family cell polarity regulator gamma
Synonyms: 2410049N21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93737
VEGA: 18
Homologene: 36487
Tstd2
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 272027
Homologene: 16403
Med28
Name: mediator complex subunit 28
Synonyms: Eg1, 1500003D12Rik, magicin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66999
Homologene: 11873
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Daw1
Name: dynein assembly factor with WDR repeat domains 1
Synonyms: 4933429D11Rik, 4930563E19Rik, Wdr69, b2b1116Clo, b2b1584Clo
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71227
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, M-type receptor, Pla2g1br
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Rusf1
Name: RUS family member 1
Synonyms: BC017158
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233913
Homologene: 11232
Rassf9
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
Synonyms: Pamci
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237504
Homologene: 3976
Gabrg2
Name: gamma-aminobutyric acid type A receptor, subunit gamma 2
Synonyms: Gabrg-2, gamma2, GABAA-R
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
Sult1b1
Name: sulfotransferase family 1B, member 1
Synonyms: Dopa/tyrosine sulfotransferase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56362
Homologene: 69169
Kank3
Name: KN motif and ankyrin repeat domains 3
Synonyms: 0610013D04Rik, D17Ertd288e, Ankrd47
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80880
Homologene: 12749
Mfsd13b
Name: major facilitator superfamily domain containing 13B
Synonyms: 4933427G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74466
Homologene: 62261
Cyp4f14
Name: cytochrome P450, family 4, subfamily f, polypeptide 14
Synonyms: 1300014O15Rik, leukotriene B4 omega hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64385
VEGA: 17
Homologene: 81872
1700102P08Rik
Name: RIKEN cDNA 1700102P08 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 112418
Homologene: 14230
Cbx8
Name: chromobox 8
Synonyms: polycomb 3, Pc3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30951
Homologene: 32199
Eef2kmt
Name: eukaryotic elongation factor 2 lysine methyltransferase
Synonyms: 5730409G15Rik, Fam86
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70511
Homologene: 45719
Pgls
Name: 6-phosphogluconolactonase
Synonyms: 1110030K05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66171
HGNC: HGNC:8903
Homologene: 6037
Tssk1
Name: testis-specific serine kinase 1
Synonyms: Tsk1, TSK-1, Tssk, Stk22a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22114
Homologene: 56448
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 83,192,698 bp
  • G to T, chromosome 1 at 150,582,296 bp
  • A to T, chromosome 1 at 181,935,728 bp
  • T to C, chromosome 2 at 60,514,940 bp
  • C to T, chromosome 2 at 82,978,581 bp
  • T to C, chromosome 2 at 83,853,605 bp
  • T to A, chromosome 2 at 131,521,106 bp
  • T to C, chromosome 2 at 178,403,761 bp
  • G to A, chromosome 3 at 132,751,216 bp
  • T to C, chromosome 4 at 46,120,461 bp
  • A to G, chromosome 4 at 156,173,035 bp
  • C to A, chromosome 5 at 24,695,535 bp
  • T to C, chromosome 5 at 45,523,474 bp
  • T to C, chromosome 5 at 87,530,651 bp
  • C to T, chromosome 5 at 124,584,297 bp
  • G to A, chromosome 5 at 143,721,646 bp
  • G to A, chromosome 7 at 50,599,472 bp
  • G to A, chromosome 7 at 65,340,340 bp
  • G to C, chromosome 7 at 96,837,331 bp
  • G to A, chromosome 7 at 120,991,833 bp
  • A to G, chromosome 7 at 127,236,841 bp
  • C to T, chromosome 7 at 128,298,101 bp
  • G to T, chromosome 8 at 71,592,836 bp
  • T to A, chromosome 9 at 108,393,240 bp
  • G to A, chromosome 10 at 78,187,860 bp
  • A to T, chromosome 10 at 102,545,344 bp
  • G to T, chromosome 10 at 103,215,345 bp
  • C to T, chromosome 11 at 41,971,732 bp
  • T to C, chromosome 11 at 58,880,340 bp
  • T to C, chromosome 11 at 83,017,724 bp
  • A to G, chromosome 11 at 119,038,916 bp
  • A to G, chromosome 12 at 91,339,119 bp
  • A to C, chromosome 12 at 117,739,644 bp
  • T to C, chromosome 14 at 24,454,941 bp
  • G to A, chromosome 14 at 70,683,731 bp
  • T to C, chromosome 14 at 76,114,275 bp
  • A to G, chromosome 16 at 5,245,358 bp
  • G to A, chromosome 16 at 17,895,259 bp
  • T to A, chromosome 17 at 32,907,985 bp
  • T to C, chromosome 17 at 33,817,943 bp
  • T to A, chromosome 17 at 71,648,777 bp
  • T to A, chromosome 18 at 80,079,901 bp
  • T to C, chromosome 18 at 86,404,873 bp
  • T to A, chromosome 19 at 9,878,406 bp
  • T to C, chromosome 19 at 41,876,590 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5282 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042867-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.