Strain Name:
C57BL/6J-MtgxR5287Btlr/Mmmh
Stock Number:
042871-MU
Citation ID:
RRID:MMRRC_042871-MU
Other Names:
R5287 (G1), C57BL/6J-MtgxR5287Btlr
Major Collection:

Strain Information

Tk1
Name: thymidine kinase 1
Synonyms: Tk-1, D530002A18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21877
Homologene: 37749
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Zfp7
Name: zinc finger protein 7
Synonyms: Krox-2, Zfp-7, KRAB7, Zfp65, mszf73-2, Zfp80, KRAB20, Zfp86-rs1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223669
VEGA: 15
Homologene: 20729
Brd7
Name: bromodomain containing 7
Synonyms: bromodomain protein 75 kDa, BP75, CELTIX1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26992
Homologene: 8085
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, HELIC2, A330064G03Rik, Ascc3l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75302
Homologene: 10102
Dnm1l
Name: dynamin 1-like
Synonyms: 6330417M19Rik, Drp1, python, Dnmlp1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76138
VEGA: 10
Homologene: 44912
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
T2
Name: brachyury 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21331
Homologene: 86977
Fezf1
Name: Fez family zinc finger 1
Synonyms: Zfp312-like, Fez, 3110069A13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73191
Homologene: 19252
Anp32a
Name: acidic nuclear phosphoprotein 32 family member A
Synonyms: pp32, Anp32
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11737
Homologene: 137229
Tmed8
Name: transmembrane p24 trafficking protein 8
Synonyms: LOC382620, 6430595O10Rik, Mem1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382620
VEGA: 12
Homologene: 19600
Clhc1
Name: clathrin heavy chain linker domain containing 1
Synonyms: 1700034F02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73324
Homologene: 17569
Phf24
Name: PHD finger protein 24
Synonyms: N28178, GINIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230085
Homologene: 18208
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237754
Homologene: 68540
Cops8
Name: COP9 signalosome subunit 8
Synonyms: Csn8, 9430009J09Rik, Sgn8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108679
Homologene: 4882
Opn4
Name: opsin 4 (melanopsin)
Synonyms: 1110007J02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30044
VEGA: 14
Homologene: 69152
Tnip2
Name: TNFAIP3 interacting protein 2
Synonyms: ABIN-2, 1810020H16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231130
Homologene: 11515
Cat
Name: catalase
Synonyms: Cs-1, Cas-1, Cas1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: 1200008N06Rik, mSYD1A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71709
VEGA: 10
Homologene: 13195
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Accs
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)
Synonyms: 2610203E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329470
Homologene: 75335
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: Smr, 4930442N21Rik, 9330180L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54650
Homologene: 9472
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76718
Homologene: 10915
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: PTP-NP, IA-2 beta, phogrin, IA-2beta, 4930425H11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Pcnx1
Name: pecanex 1
Synonyms: 3526401J03Rik, 2900024E21Rik, Pcnx
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: LOC268816, Gm628
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268816
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Ces1e
Name: carboxylesterase 1E
Synonyms: Es-22, Eg, egasyn, Es22
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 434484
Homologene: 128391
Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
Synonyms: 1700061G19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78625
Homologene: 28378
Zfp687
Name: zinc finger protein 687
Synonyms: 4931408L03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78266
Homologene: 10827
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Mmp8
Name: matrix metallopeptidase 8
Synonyms: Collagenase-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17394
VEGA: 9
HGNC: HGNC:7175
Homologene: 22482
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Phkg2
Name: phosphorylase kinase, gamma 2 (testis)
Synonyms: 1500017I02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68961
HGNC: HGNC:8931
Homologene: 47915
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbccr1, Fam5a, Dbc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Cpox
Name: coproporphyrinogen oxidase
Synonyms: clone 560, cac, Cpo, nct, M100835
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12892
VEGA: 16
HGNC: HGNC:2321
Homologene: 76
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208372
Homologene: 16382
Itga7
Name: integrin alpha 7
Synonyms: [a]7, alpha7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16404
VEGA: 10
HGNC: HGNC:6143
Homologene: 37592
Pheta1
Name: PH domain containing endocytic trafficking adaptor 1
Synonyms: A230106M15Rik, Ses1, Fam109a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231717
Homologene: 16966
Or6b2
Name: olfactory receptor family 6 subfamily B member 2
Synonyms: GA_x6K02T2R7CC-81277975-81278913, MOR103-3, Olfr1416
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259040
Homologene: 17472
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Pgc1, PPAR Gamma Coactivator-1, Pgco1, Pgc-1alpha, Pgc-1alphaa, A830037N07Rik, Gm11133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Spdye4c
Name: speedy/RINGO cell cycle regulator family, member E4C
Synonyms: LOC241634, Gm355
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241634
Homologene: 78093
Arpin
Name: actin-related protein 2/3 complex inhibitor
Synonyms: 2610034B18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70420
Homologene: 128480
Hand2
Name: heart and neural crest derivatives expressed 2
Synonyms: dHAND, Thing2, Hed, Ehand2, bHLHa26
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15111
HGNC: HGNC:4808
Homologene: 32092
Gm6818
Name: predicted gene 6818
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627975
Homologene: 80005
Tfap2e
Name: transcription factor AP-2, epsilon
Synonyms: AP-2e, Tcfap2e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 332937
Homologene: 2422
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 85,610,824 bp
  • T to C, chromosome 1 at 90,014,388 bp
  • C to T, chromosome 1 at 90,606,620 bp
  • A to T, chromosome 1 at 92,480,297 bp
  • C to T, chromosome 1 at 195,062,411 bp
  • G to T, chromosome 2 at 76,732,092 bp
  • T to C, chromosome 2 at 91,009,207 bp
  • T to C, chromosome 2 at 93,835,953 bp
  • T to C, chromosome 2 at 103,474,360 bp
  • T to C, chromosome 2 at 127,231,687 bp
  • T to C, chromosome 2 at 128,592,640 bp
  • T to C, chromosome 3 at 95,008,711 bp
  • A to T, chromosome 4 at 42,933,831 bp
  • A to G, chromosome 4 at 68,792,964 bp
  • G to A, chromosome 4 at 75,954,168 bp
  • T to C, chromosome 4 at 126,734,646 bp
  • C to T, chromosome 4 at 128,486,884 bp
  • A to G, chromosome 5 at 34,513,764 bp
  • G to A, chromosome 5 at 51,462,825 bp
  • A to G, chromosome 5 at 121,852,731 bp
  • C to T, chromosome 6 at 23,248,011 bp
  • T to C, chromosome 7 at 29,697,838 bp
  • T to G, chromosome 7 at 38,400,487 bp
  • T to C, chromosome 7 at 46,269,329 bp
  • T to C, chromosome 7 at 79,928,249 bp
  • GCTGCCGGACGAGTGGCCT to GCT, chromosome 7 at 127,582,757 bp
  • A to G, chromosome 7 at 128,766,136 bp
  • C to T, chromosome 8 at 57,322,045 bp
  • G to T, chromosome 8 at 88,357,541 bp
  • T to G, chromosome 8 at 93,208,612 bp
  • G to T, chromosome 9 at 7,567,506 bp
  • A to T, chromosome 9 at 62,341,993 bp
  • G to A, chromosome 9 at 67,242,359 bp
  • T to A, chromosome 10 at 58,575,705 bp
  • T to C, chromosome 10 at 78,590,037 bp
  • C to A, chromosome 10 at 128,943,158 bp
  • A to G, chromosome 11 at 29,578,244 bp
  • A to T, chromosome 11 at 34,403,058 bp
  • A to G, chromosome 11 at 49,169,607 bp
  • A to T, chromosome 11 at 69,349,069 bp
  • A to T, chromosome 11 at 117,816,541 bp
  • A to G, chromosome 12 at 3,496,893 bp
  • A to T, chromosome 12 at 81,982,051 bp
  • C to A, chromosome 12 at 87,174,183 bp
  • A to T, chromosome 12 at 117,211,862 bp
  • G to A, chromosome 13 at 3,575,744 bp
  • G to A, chromosome 14 at 30,816,820 bp
  • T to C, chromosome 14 at 34,592,937 bp
  • C to T, chromosome 15 at 64,716,152 bp
  • TGGAG to TG, chromosome 15 at 73,783,074 bp
  • G to A, chromosome 15 at 76,891,222 bp
  • A to C, chromosome 16 at 16,333,868 bp
  • G to A, chromosome 16 at 58,675,286 bp
  • T to C, chromosome 16 at 94,459,844 bp
  • A to T, chromosome 17 at 8,418,003 bp
  • A to T, chromosome 17 at 25,861,467 bp
  • G to T, chromosome 17 at 56,876,221 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5287 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042871-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.