Strain Name:
C57BL/6J-MtgxR5289Btlr/Mmmh
Stock Number:
042872-MU
Citation ID:
RRID:MMRRC_042872-MU
Other Names:
R5289 (G1), C57BL/6J-MtgxR5289Btlr
Major Collection:

Strain Information

Nes
Name: nestin
Synonyms: Ifaprc2, Marc2, ESTM46, RC2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: D5Ertd679e, BTF2, 34kDa, 5033417D07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20116
Homologene: 133143
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: mechanistic target of rapamycin (serine/threonine kinase), Frap1, RAFT1, 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, RAPT1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: ASTBDN, tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Diaph3
Name: diaphanous related formin 3
Synonyms: mDia2, Diap3, Drf3, p134MDia2, 4930417P13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: 4932438A13Rik, Tweek, FSA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: Psa, MP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76501
Homologene: 8584
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233064
Homologene: 15927
Cnr1
Name: cannabinoid receptor 1
Synonyms: CB1R, CB1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12801
HGNC: HGNC:2159
Homologene: 7273
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Dpy19l2
Name: dpy-19 like 2
Synonyms: 4932443J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320752
VEGA: 9
Homologene: 77569
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Nid2
Name: nidogen 2
Synonyms: entactin 2, entactin-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272347
Homologene: 12358
Ahcyl1
Name: S-adenosylhomocysteine hydrolase-like 1
Synonyms: Ahcy-rs3, 1110034F20Rik, IRBIT, DCAL
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229709
HGNC: HGNC:344
Homologene: 77353
Glt1d1
Name: glycosyltransferase 1 domain containing 1
Synonyms: 5730455A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319804
Homologene: 16965
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Gabarapl2
Name: GABA type A receptor associated protein like 2
Synonyms: GATE-16, 0610012F20Rik, Gef2, 2900019O08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93739
Homologene: 68550
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269902
Homologene: 104832
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: SNAT4, Ata3, 1110012E16Rik, 1700012A18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Hc
Name: hemolytic complement
Synonyms: C5, C5a, Hfib2, He
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Ifi30
Name: interferon gamma inducible protein 30
Synonyms: lysosomal thio reductase IP30 precursor, GILT, IP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65972
VEGA: 8
HGNC: HGNC:5398
Homologene: 38171
Diras1
Name: DIRAS family, GTP-binding RAS-like 1
Synonyms: Di-Ras1, GBTS1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208666
Homologene: 64823
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox2, Aox-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: Tmem180, 4930449A08Rik, 4930538D17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75146
Homologene: 12592
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: Hrlrrp, D330003I11Rik, Serdin1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574428
Homologene: 12995
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Tas2r110
Name: taste receptor, type 2, member 110
Synonyms: STC 9-1, mt2r57, T2R10, Tas2r10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387344
Homologene: 130069
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218989
Homologene: 49506
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
Skint8
Name: selection and upkeep of intraepithelial T cells 8
Synonyms: OTTMUSG00000009475
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639774
Homologene: 106613
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
Hgd
Name: homogentisate 1, 2-dioxygenase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15233
HGNC: HGNC:4892
Homologene: 156
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm-2, Pgm1a, 2610020G18Rik, Pgm2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68810
Homologene: 44892
Dsc1
Name: desmocollin 1
Synonyms: Dsc1a, Dsc1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Zfp62
Name: zinc finger protein 62
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22720
Homologene: 40686
Cnr2
Name: cannabinoid receptor 2
Synonyms: CB2-R, cannabinoid receptor 2 (spleen), CB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12802
HGNC: HGNC:2160
Homologene: 1389
Prss41
Name: serine protease 41
Synonyms: 4931440B09Rik, Tessp1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71003
Homologene: 28091
Zfp952
Name: zinc finger protein 952
Synonyms: C920016K16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240067
Homologene: 128790
Ptpn9
Name: protein tyrosine phosphatase, non-receptor type 9
Synonyms: Meg2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56294
VEGA: 9
HGNC: HGNC:9661
Homologene: 2121
Snrpa1
Name: small nuclear ribonucleoprotein polypeptide A'
Synonyms: U2 snRNP-A', 1500015N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68981
Homologene: 2325
Dnaaf6rt
Name: dynein axonemal assembly factor 6, retrotransposed
Synonyms: Pih1d3, Dnaaf6, 4930521A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74708
Homologene: 16553
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, 9830145H18Rik, D5Buc24e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Lzts3
Name: leucine zipper, putative tumor suppressor family member 3
Synonyms: Prosapip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241638
Homologene: 8824
Prok1
Name: prokineticin 1
Synonyms: EG-VEGF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 246691
Homologene: 13023
RP23-434H17.6
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 31,223,527 bp
  • T to A, chromosome 1 at 58,092,558 bp
  • A to G, chromosome 2 at 34,996,014 bp
  • C to T, chromosome 2 at 101,898,894 bp
  • T to C, chromosome 2 at 130,636,101 bp
  • C to A, chromosome 3 at 37,000,109 bp
  • A to T, chromosome 3 at 51,455,894 bp
  • C to A, chromosome 3 at 87,978,418 bp
  • A to T, chromosome 3 at 102,934,253 bp
  • G to C, chromosome 3 at 107,239,619 bp
  • A to G, chromosome 3 at 107,669,890 bp
  • G to A, chromosome 3 at 122,426,769 bp
  • T to G, chromosome 3 at 152,248,072 bp
  • T to A, chromosome 4 at 3,905,545 bp
  • T to A, chromosome 4 at 33,943,910 bp
  • T to A, chromosome 4 at 99,967,069 bp
  • C to A, chromosome 4 at 111,950,193 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • A to G, chromosome 4 at 135,917,007 bp
  • T to C, chromosome 4 at 148,466,092 bp
  • T to A, chromosome 5 at 3,630,118 bp
  • C to A, chromosome 5 at 72,255,123 bp
  • G to A, chromosome 5 at 104,519,657 bp
  • C to T, chromosome 5 at 124,584,297 bp
  • A to G, chromosome 5 at 127,644,356 bp
  • T to A, chromosome 6 at 47,863,181 bp
  • G to T, chromosome 6 at 97,302,348 bp
  • T to A, chromosome 6 at 121,386,700 bp
  • T to C, chromosome 6 at 125,667,510 bp
  • T to C, chromosome 6 at 132,868,009 bp
  • A to C, chromosome 7 at 30,267,875 bp
  • A to G, chromosome 7 at 41,399,974 bp
  • A to G, chromosome 7 at 66,069,573 bp
  • T to C, chromosome 7 at 80,738,724 bp
  • A to T, chromosome 8 at 70,766,601 bp
  • A to G, chromosome 8 at 80,612,319 bp
  • T to C, chromosome 8 at 111,942,595 bp
  • A to G, chromosome 9 at 24,695,997 bp
  • T to C, chromosome 9 at 57,060,063 bp
  • C to A, chromosome 10 at 27,212,073 bp
  • G to A, chromosome 10 at 81,022,244 bp
  • T to C, chromosome 10 at 117,045,487 bp
  • T to A, chromosome 11 at 49,217,148 bp
  • C to G, chromosome 11 at 70,466,004 bp
  • A to G, chromosome 11 at 97,240,927 bp
  • A to G, chromosome 13 at 81,521,084 bp
  • T to C, chromosome 14 at 19,805,311 bp
  • G to A, chromosome 14 at 48,486,810 bp
  • A to G, chromosome 14 at 86,981,678 bp
  • A to T, chromosome 15 at 97,010,348 bp
  • A to G, chromosome 16 at 34,252,341 bp
  • A to G, chromosome 16 at 37,628,551 bp
  • A to G, chromosome 17 at 20,471,604 bp
  • T to C, chromosome 17 at 23,844,040 bp
  • T to C, chromosome 17 at 33,003,247 bp
  • A to G, chromosome 17 at 64,651,227 bp
  • A to T, chromosome 18 at 20,101,853 bp
  • G to T, chromosome 18 at 64,546,087 bp
  • G to T, chromosome 19 at 46,268,139 bp
  • A to G, chromosome 19 at 46,368,280 bp
  • C to T, chromosome 19 at 57,657,082 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5289 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042872-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.