Strain Name:
C57BL/6J-MtgxR5290Btlr/Mmmh
Stock Number:
042873-MU
Citation ID:
RRID:MMRRC_042873-MU
Other Names:
R5290 (G1), C57BL/6J-MtgxR5290Btlr
Major Collection:

Gene Information

Gsn
Name: gelsolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: 2210016I17Rik, D1Ertd202e, Plu1, 2010009J12Rik, Rb-Bp2, PLU-1, Jarid1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75605
Homologene: 48448
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20116
Homologene: 133143
Apod
Name: apolipoprotein D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11815
HGNC: HGNC:612
Homologene: 1246
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, D230004K18Rik, b2b1625.2Clo, Gp330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Smad2
Name: SMAD family member 2
Synonyms: Smad 2, Madr2, Madh2, 7120426M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17126
HGNC: HGNC:6768
Homologene: 21197
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, Dnchc1, dynein heavy chain, retrograde transport, 9930018I23Rik, Dnec1, Loa, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, InsP3R type I, wblo, IP3R1, Ip3r, Pcp1, Itpr-1, Pcp-1, opt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70767
Homologene: 3447
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74775
Homologene: 10011
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Bend5
Name: BEN domain containing 5
Synonyms: 2310026E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67621
Homologene: 41574
Gtf2f2
Name: general transcription factor IIF, polypeptide 2
Synonyms: 1110031C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68705
VEGA: 14
HGNC: HGNC:4653
Homologene: 37884
Zswim1
Name: zinc finger SWIM-type containing 1
Synonyms: 2410003H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71971
Homologene: 12429
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 214764
Homologene: 27985
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229473
Homologene: 9057
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229474
Homologene: 18920
Ttn
Name: titin
Synonyms: D330041I19Rik, mdm, L56, connectin, 2310074I15Rik, 2310057K23Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Gdpd4
Name: glycerophosphodiester phosphodiesterase domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233537
Homologene: 18606
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
Irf2bp1
Name: interferon regulatory factor 2 binding protein 1
Synonyms: 6330414O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272359
Homologene: 32276
Wdr78
Name: WD repeat domain 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242584
Homologene: 11702
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229574
Homologene: 134146
Arfgef3
Name: ARFGEF family member 3
Synonyms: D10Bwg1379e, BIG3, B930094H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: D1Ucla3, CPSase I, CPS, 4732433M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, Fmi1, flamingo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, Fln2, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627805
Homologene: 129678
Mgarp
Name: mitochondria localized glutamic acid rich protein
Synonyms: Osap, 4930583H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67749
Homologene: 49858
Stmnd1
Name: stathmin domain containing 1
Synonyms: LOC380842, Gm1574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380842
VEGA: 13
Homologene: 54416
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246791
Homologene: 44937
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: 9130221N23Rik, Niemann-Pick disease, type C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Plekhh3
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217198
Homologene: 11787
Lypd11
Name: Ly6/PLAUR domain containing 11
Synonyms: Gm4763
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210155
Gabrp
Name: gamma-aminobutyric acid (GABA) A receptor, pi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216643
HGNC: HGNC:4089
Homologene: 22798
Fkbpl
Name: FK506 binding protein-like
Synonyms: WISp39, NG7, DIR1, WAF-1/CIP1 stabilizing protein 39, Ppiase-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 2010013I23Rik, 9130206N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103406
Homologene: 88124
Lrrc14
Name: leucine rich repeat containing 14
Synonyms: E130306I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223664
Homologene: 40970
Cd7
Name: CD7 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12516
HGNC: HGNC:1695
Homologene: 4471
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 245174
Homologene: 136215
Abi3bp
Name: ABI gene family, member 3 (NESH) binding protein
Synonyms: D930038M13Rik, 5033411B22Rik, TARSH, eratin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Vmn1r177
Name: vomeronasal 1 receptor 177
Synonyms: V1rd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384572
Homologene: 122945
Msl2
Name: MSL complex subunit 2
Synonyms: Msl2l1, E130103E02Rik, Rnf184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77853
Homologene: 10021
Fam92a
Name: family with sequence similarity 92, member A
Synonyms: 6720467C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68099
Homologene: 12234
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 1110054G21Rik, 9530062N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68770
Homologene: 10713
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Olfr282
Name: olfactory receptor 282
Synonyms: GA_x6K02T2NBG7-5293798-5292872, MOR160-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 258449
Homologene: 133621
Olfr509
Name: olfactory receptor 509
Synonyms: MOR267-14, GA_x6K02T2PBJ9-10976304-10975339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258369
Homologene: 131128
Gpr162
Name: G protein-coupled receptor 162
Synonyms: A-2, Grca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14788
Homologene: 8400
Trim72
Name: tripartite motif-containing 72
Synonyms: mitsugumin 53, MG53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434246
Homologene: 66924
Rpl12-ps1
Name: ribosomal protein L12, pseudogene 1
Synonyms: Gm4957
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241053
Ccdc113
Name: coiled-coil domain containing 113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244608
Homologene: 40927
Olfr446
Name: olfactory receptor 446
Synonyms: GA_x6K02T2P3E9-4632269-4631343, MOR261-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258292
Homologene: 17179
Vmn1r57
Name: vomeronasal 1 receptor 57
Synonyms: Gm7519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 665150
Homologene: 41799
1110008E08Rik
Name: RIKEN cDNA 1110008E08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Igkv1-133
Name: immunoglobulin kappa variable 1-133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 628027
Gm7889
Name: predicted gene 7889
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 666009
RP23-422N18.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
B020004C17Rik
Name: RIKEN cDNA B020004C17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 432860
VEGA: 14
Homologene: 128423
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 36,958,342 bp
  • A to G, chromosome 1 at 67,172,709 bp
  • C to A, chromosome 1 at 93,975,950 bp
  • T to C, chromosome 1 at 134,622,099 bp
  • G to A, chromosome 2 at 35,296,472 bp
  • T to C, chromosome 2 at 69,513,354 bp
  • A to T, chromosome 2 at 76,897,240 bp
  • T to A, chromosome 2 at 150,238,309 bp
  • C to T, chromosome 2 at 164,825,925 bp
  • G to A, chromosome 3 at 51,388,966 bp
  • T to C, chromosome 3 at 83,899,265 bp
  • A to G, chromosome 3 at 84,474,527 bp
  • A to T, chromosome 3 at 93,220,566 bp
  • T to C, chromosome 3 at 95,589,181 bp
  • A to T, chromosome 3 at 95,853,545 bp
  • C to T, chromosome 3 at 98,877,177 bp
  • T to C, chromosome 4 at 12,171,195 bp
  • A to T, chromosome 4 at 103,049,533 bp
  • G to A, chromosome 4 at 111,433,480 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • G to A, chromosome 4 at 141,473,816 bp
  • G to A, chromosome 5 at 20,789,716 bp
  • T to C, chromosome 6 at 29,457,554 bp
  • A to G, chromosome 6 at 42,928,038 bp
  • A to G, chromosome 6 at 67,725,579 bp
  • T to C, chromosome 6 at 108,406,145 bp
  • C to A, chromosome 6 at 124,861,269 bp
  • A to G, chromosome 7 at 5,221,320 bp
  • T to C, chromosome 7 at 15,626,849 bp
  • G to A, chromosome 7 at 19,004,998 bp
  • A to T, chromosome 7 at 23,866,073 bp
  • T to C, chromosome 7 at 24,723,411 bp
  • A to G, chromosome 7 at 97,966,336 bp
  • C to T, chromosome 7 at 108,646,548 bp
  • G to T, chromosome 7 at 128,010,004 bp
  • T to C, chromosome 7 at 133,650,566 bp
  • G to A, chromosome 8 at 84,713,777 bp
  • C to A, chromosome 8 at 95,540,796 bp
  • T to C, chromosome 9 at 101,101,407 bp
  • C to T, chromosome 9 at 105,946,083 bp
  • C to T, chromosome 9 at 108,843,158 bp
  • T to C, chromosome 9 at 110,617,831 bp
  • T to C, chromosome 10 at 18,600,460 bp
  • CTCAGACTGGTGTCAGAC to CTCAGAC, chromosome 10 at 81,246,710 bp
  • T to A, chromosome 11 at 6,222,221 bp
  • A to T, chromosome 11 at 33,567,310 bp
  • T to A, chromosome 11 at 83,029,025 bp
  • T to A, chromosome 11 at 101,166,571 bp
  • T to G, chromosome 11 at 121,038,110 bp
  • C to A, chromosome 12 at 71,188,791 bp
  • T to C, chromosome 12 at 108,898,042 bp
  • A to T, chromosome 12 at 110,615,068 bp
  • A to G, chromosome 13 at 46,299,598 bp
  • T to C, chromosome 14 at 57,016,579 bp
  • T to C, chromosome 14 at 75,897,649 bp
  • T to A, chromosome 15 at 76,713,943 bp
  • T to C, chromosome 15 at 98,438,332 bp
  • A to G, chromosome 15 at 98,912,242 bp
  • T to A, chromosome 16 at 31,311,066 bp
  • T to A, chromosome 16 at 56,642,475 bp
  • A to T, chromosome 16 at 90,554,210 bp
  • C to A, chromosome 17 at 20,471,403 bp
  • T to C, chromosome 17 at 34,565,289 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to T, chromosome 18 at 6,234,882 bp
  • G to A, chromosome 18 at 10,542,427 bp
  • C to T, chromosome 18 at 76,262,724 bp
  • T to G, chromosome 19 at 24,131,204 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5290 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042873-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.