Strain Name:
C57BL/6J-MtgxR5296Btlr/Mmmh
Stock Number:
042879-MU
Citation ID:
RRID:MMRRC_042879-MU
Other Names:
R5296 (G1), C57BL/6J-MtgxR5296Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Dhx35
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 35
Synonyms: Ddx35, 1200009D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71715
Homologene: 6406
Ythdf1
Name: YTH N6-methyladenosine RNA binding protein 1
Synonyms: 2210410K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228994
Homologene: 9844
Traf2
Name: TNF receptor-associated factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22030
Homologene: 22520
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Ruvbl1
Name: RuvB-like protein 1
Synonyms: Pontin52, 2510009G06Rik, Tip49a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56505
Homologene: 37839
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 212712
Homologene: 32249
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Ddi2
Name: DNA-damage inducible protein 2
Synonyms: 9130022E05Rik, 1110056G13Rik, 1700027M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68817
Homologene: 121661
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Cd300lb
Name: CD300 molecule like family member B
Synonyms: Clm7, LOC217304, CLM-7, LMIR5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217304
Homologene: 18374
Zfp60
Name: zinc finger protein 60
Synonyms: Mfg-3, Mfg3, 6330516O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22718
Homologene: 137228
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216766
Homologene: 9155
Thsd1
Name: thrombospondin, type I, domain 1
Synonyms: 4833423O18Rik, Tmtsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56229
Homologene: 10264
Uts2
Name: urotensin 2
Synonyms: urotensin II precursor, prepro-UII, Ucn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24111
Homologene: 4939
Fzd2
Name: frizzled class receptor 2
Synonyms: Mfz10a, Mfz10, Fz10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57265
HGNC: HGNC:4040
Homologene: 20377
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b1203Clo, b2b1279Clo, b2b598Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213435
Homologene: 35278
Sema6b
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Synonyms: VIb, semaZ, Sema, Seman
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20359
VEGA: 17
Homologene: 8428
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: CFEX, Pat1, B930010B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 171429
Homologene: 99903
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Flad1
Name: flavin adenine dinucleotide synthetase 1
Synonyms: Pp591, A930017E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319945
Homologene: 115598
Hltf
Name: helicase-like transcription factor
Synonyms: P113, Snf2l3, Smarca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20585
Homologene: 30136
Mroh3
Name: maestro heat-like repeat family member 3
Synonyms: 2310006M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76422
Thbd
Name: thrombomodulin
Synonyms: CD141, TM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21824
Homologene: 308
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 403088
Homologene: 74374
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Ceacam15
Name: carcinoembryonic antigen-related cell adhesion molecule 15
Synonyms: C430002N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101434
Homologene: 131210
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Zfp882
Name: zinc finger protein 882
Synonyms: ENSMUSG00000052439
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382019
Homologene: 136303
Olfr136
Name: olfactory receptor 136
Synonyms: MOR256-7, GA_x6K02T2PSCP-2779375-2780313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258803
Homologene: 119758
Epsti1
Name: epithelial stromal interaction 1 (breast)
Synonyms: 5033415K03Rik, BRESI1, 2310046K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108670
VEGA: 14
Homologene: 12630
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: 4931400F03Rik, eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74053
Homologene: 12938
Lancl2
Name: LanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms: 1700003F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71835
HGNC: HGNC:6509
Homologene: 23116
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192950
Homologene: 135717
Pygm
Name: muscle glycogen phosphorylase
Synonyms: PG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19309
HGNC: HGNC:9726
Homologene: 2145
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270201
Homologene: 14805
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, Melk2, C030044P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Gmeb2
Name: glucocorticoid modulatory element binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229004
HGNC: HGNC:4371
Homologene: 8228
Lrrc23
Name: leucine rich repeat containing 23
Synonyms: 4921537K05Rik, Lrpb7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16977
Homologene: 5082
Slc25a11
Name: solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Synonyms: 2310022P18Rik, 2oxoc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67863
Homologene: 2637
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620672
Homologene: 115466
Troap
Name: trophinin associated protein
Synonyms: tastin, E130301L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78733
VEGA: 15
Homologene: 28697
Apobr
Name: apolipoprotein B receptor
Synonyms: Apob-48r, Apob48r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171504
Homologene: 26695
Gm9892
Name: predicted gene 9892
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100040220
Olfr1269
Name: olfactory receptor 1269
Synonyms: GA_x6K02T2Q125-51551618-51550689, MOR228-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258339
Homologene: 133727
Lmcd1
Name: LIM and cysteine-rich domains 1
Synonyms: dyxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30937
HGNC: HGNC:6633
Homologene: 22823
Bhlhe41
Name: basic helix-loop-helix family, member e41
Synonyms: DEC2, Sharp1, Bhlhb3, 6430520M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 79362
Homologene: 137371
Mfsd13b
Name: major facilitator superfamily domain containing 13B
Synonyms: 4933427G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74466
Homologene: 62261
Cavin2
Name: caveolae associated 2
Synonyms: cavin 2, Sdpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20324
Homologene: 3422
Olfr419
Name: olfactory receptor 419
Synonyms: GA_x6K02T2P20D-20891507-20892448, MOR267-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258710
Homologene: 72017
Sapcd1
Name: suppressor APC domain containing 1
Synonyms: G7d, Ng23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78376
Homologene: 86703
Gvin-ps3
Name: GTPase, very large interferon inducible, pseudogene 3
Synonyms: Gm8979, Gm21884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668108
Olfr908
Name: olfactory receptor 908
Synonyms: GA_x6K02T2PVTD-32216179-32217111, MOR165-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258872
VEGA: 9
Homologene: 74149
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: G4.8, Dnl1ll, 2310005K03Rik, Dnase1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Mir3097
Name: microRNA 3097
Synonyms: mmu-mir-3097
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100526557
VEGA: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 51,289,870 bp
  • T to C, chromosome 1 at 56,796,907 bp
  • T to C, chromosome 1 at 65,216,018 bp
  • G to A, chromosome 1 at 136,095,785 bp
  • A to G, chromosome 1 at 136,196,323 bp
  • C to T, chromosome 1 at 140,609,615 bp
  • G to T, chromosome 1 at 174,250,756 bp
  • A to G, chromosome 2 at 25,520,440 bp
  • A to T, chromosome 2 at 90,118,699 bp
  • A to T, chromosome 2 at 148,406,983 bp
  • G to A, chromosome 2 at 158,831,805 bp
  • A to C, chromosome 2 at 180,193,801 bp
  • A to T, chromosome 2 at 180,912,188 bp
  • A to G, chromosome 2 at 181,255,986 bp
  • T to C, chromosome 3 at 20,108,112 bp
  • T to C, chromosome 3 at 89,411,196 bp
  • G to T, chromosome 4 at 141,684,765 bp
  • G to T, chromosome 4 at 150,999,051 bp
  • G to T, chromosome 4 at 154,989,999 bp
  • T to C, chromosome 5 at 35,021,104 bp
  • C to T, chromosome 5 at 110,295,551 bp
  • G to T, chromosome 6 at 42,587,510 bp
  • T to G, chromosome 6 at 57,724,582 bp
  • T to C, chromosome 6 at 88,485,908 bp
  • A to G, chromosome 6 at 112,315,588 bp
  • C to A, chromosome 6 at 124,774,482 bp
  • C to T, chromosome 6 at 145,862,968 bp
  • A to G, chromosome 7 at 16,673,196 bp
  • T to A, chromosome 7 at 27,738,530 bp
  • A to G, chromosome 7 at 85,137,022 bp
  • A to T, chromosome 7 at 106,081,848 bp
  • T to A, chromosome 7 at 120,991,738 bp
  • A to C, chromosome 7 at 126,588,024 bp
  • C to T, chromosome 8 at 22,259,571 bp
  • T to C, chromosome 8 at 52,196,929 bp
  • A to T, chromosome 8 at 71,333,388 bp
  • T to A, chromosome 8 at 71,914,360 bp
  • A to C, chromosome 8 at 85,355,431 bp
  • T to C, chromosome 9 at 38,516,116 bp
  • C to T, chromosome 9 at 108,860,646 bp
  • G to C, chromosome 9 at 110,436,127 bp
  • G to A, chromosome 10 at 12,401,355 bp
  • A to G, chromosome 10 at 119,929,928 bp
  • T to C, chromosome 11 at 6,605,745 bp
  • C to A, chromosome 11 at 58,130,061 bp
  • C to T, chromosome 11 at 69,458,920 bp
  • T to C, chromosome 11 at 70,646,185 bp
  • C to T, chromosome 11 at 102,606,155 bp
  • T to C, chromosome 11 at 114,924,937 bp
  • A to G, chromosome 12 at 117,883,416 bp
  • T to A, chromosome 14 at 77,904,650 bp
  • T to G, chromosome 15 at 35,876,413 bp
  • G to A, chromosome 15 at 85,817,118 bp
  • T to A, chromosome 15 at 99,078,817 bp
  • A to T, chromosome 15 at 99,241,939 bp
  • T to A, chromosome 17 at 20,554,341 bp
  • T to C, chromosome 17 at 24,576,074 bp
  • T to A, chromosome 17 at 35,026,731 bp
  • C to T, chromosome 17 at 38,335,456 bp
  • T to A, chromosome 17 at 56,127,091 bp
  • G to A, chromosome 19 at 6,384,579 bp
  • A to G, chromosome 19 at 56,357,366 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5296 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042879-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.