Strain Name:
C57BL/6J-MtgxR5306Btlr/Mmmh
Stock Number:
042889-MU
Citation ID:
RRID:MMRRC_042889-MU
Other Names:
R5306 (G1), C57BL/6J-MtgxR5306Btlr
Major Collection:

Strain Information

Tyr
Name: tyrosinase
Synonyms: Oca1, skc35
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Gfap
Name: glial fibrillary acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14580
HGNC: HGNC:4235
Homologene: 1554
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: D230038D11Rik, 1810033J14Rik, Mll5, 9530077A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: 2900024N03Rik, D930043C02Rik, 9430019J22Rik, Mnab, Rnf164
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Cep104
Name: centrosomal protein 104
Synonyms: BC046331
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230967
Homologene: 44919
Api5
Name: apoptosis inhibitor 5
Synonyms: AAC-11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11800
HGNC: HGNC:594
Homologene: 4809
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, D15F32S1h, D7H15F32S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, Ki67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Skic3
Name: SKI3 subunit of superkiller complex
Synonyms: Ttc37
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233064
Homologene: 15927
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Gpr3
Name: G-protein coupled receptor 3
Synonyms: Gpcr3, Gpcr21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14748
HGNC: HGNC:4484
Homologene: 31303
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Plpp1
Name: phospholipid phosphatase 1
Synonyms: Hpic53, LPP-1, LPP1, Lipid phosphate phosphatase 1, mPAP, Ppap2a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19012
VEGA: 13
HGNC: HGNC:9228
Homologene: 134049
Zfp408
Name: zinc finger protein 408
Synonyms: LOC381410
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381410
Homologene: 11687
Exosc10
Name: exosome component 10
Synonyms: Pmscl2, p2, p3, p4, RRP6, PM-Scl, PM/Scl-100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Zfp870
Name: zinc finger protein 870
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240066
VEGA: 17
Homologene: 48189
Zfp459
Name: zinc finger protein 459
Synonyms: Rslcan-14, 9930025G17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328274
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229474
Homologene: 18920
Pced1a
Name: PC-esterase domain containing 1A
Synonyms: Fam113a, A930025D01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319513
Homologene: 11241
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: Urkl1, 1110007H10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68556
Homologene: 101414
Prss38
Name: serine protease 38
Synonyms: Gm249, LOC216797
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216797
Homologene: 18831
Ints11
Name: integrator complex subunit 11
Synonyms: Cpsf3l, 2410006F12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71957
Homologene: 9894
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, LGL3, tomosyn 1, 0710001E20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MHC2A, Myhs-f1, Myhs-f, Myhsf1, MyHC-IIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: OATP-B, Slc21a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101488
Homologene: 21419
Ccdc106
Name: coiled-coil domain containing 106
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232821
Homologene: 81845
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70729
Homologene: 135990
Polg2
Name: polymerase (DNA directed), gamma 2, accessory subunit
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50776
HGNC: HGNC:9180
Homologene: 5221
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98402
Homologene: 8726
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76132
Homologene: 32781
Fmo5
Name: flavin containing monooxygenase 5
Synonyms: 5033418D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14263
HGNC: HGNC:3773
Homologene: 68185
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Tmem236
Name: transmembrane protein 236
Synonyms: 2010003H20Rik, Fam23a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 625286
Homologene: 46598
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384534
Homologene: 129605
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: c-neu, HER-2, Neu, Neu oncogene, ErbB-2, l11Jus8, c-erbB2, HER2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Or6c70
Name: olfactory receptor family 6 subfamily C member 70
Synonyms: GA_x6K02T2PULF-11553313-11552381, MOR113-5, Olfr814, MOR113-8
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259165
Homologene: 133585
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 620913
Homologene: 83188
Cmbl
Name: carboxymethylenebutenolidase homolog
Synonyms: 2310016A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69574
Homologene: 100714
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Capsl
Name: calcyphosine-like
Synonyms: 1700028N11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75568
VEGA: 15
Homologene: 16959
Smyd4
Name: SET and MYND domain containing 4
Synonyms: G430029E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319822
Homologene: 35098
Ccdc121rt3
Name: coiled-coil domain containing 121, retrogene 3
Synonyms: Gm6583
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625424
Homologene: 116059
Ttc29
Name: tetratricopeptide repeat domain 29
Synonyms: 1700031F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73301
Homologene: 12918
Psph
Name: phosphoserine phosphatase
Synonyms: PSPase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100678
HGNC: HGNC:9577
Homologene: 31245
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAAR alpha1, Gabra-1, GABAA alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Brdt
Name: bromodomain, testis-specific
Synonyms: Fsrg3, 7420412D09Rik, Brd6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114642
HGNC: HGNC:1105
Homologene: 21064
Asb14
Name: ankyrin repeat and SOCS box-containing 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 142687
Homologene: 15445
Serpine3
Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
Synonyms: E130113E03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319433
VEGA: 14
Homologene: 53117
Or4l1
Name: olfactory receptor family 4 subfamily L member 1
Synonyms: Olfr723, GA_x6K02T2PMLR-5600424-5599495, MOR247-4, MOR247-3P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 259147
Homologene: 71986
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24056
Homologene: 23450
Ifit3
Name: interferon-induced protein with tetratricopeptide repeats 3
Synonyms: Ifi49
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15959
HGNC: HGNC:5411
Homologene: 1189
Pcdha11
Name: protocadherin alpha 11
Synonyms: A830022B16Rik, Cnr7, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Mrgprb13
Name: MAS-related GPR, member B13
Synonyms: MrgB13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620137
Homologene: 83620
Dynlt1c
Name: dynein light chain Tctex-type 1C
Synonyms: Dynlt1d
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100040563
Homologene: 4754
Rab11bos1
Name: RAB11B, member RAS oncogene family, opposite strand 1
Synonyms: Gm17251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 115488819
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 54,926,203 bp
  • T to C, chromosome 1 at 89,144,275 bp
  • G to C, chromosome 1 at 90,801,531 bp
  • T to A, chromosome 1 at 170,349,399 bp
  • A to T, chromosome 2 at 14,219,164 bp
  • A to G, chromosome 2 at 37,381,870 bp
  • T to A, chromosome 2 at 91,646,345 bp
  • A to T, chromosome 2 at 94,423,466 bp
  • T to A, chromosome 2 at 130,419,171 bp
  • T to C, chromosome 2 at 175,169,579 bp
  • A to G, chromosome 2 at 181,574,367 bp
  • G to A, chromosome 3 at 84,451,418 bp
  • C to T, chromosome 3 at 89,223,071 bp
  • G to T, chromosome 3 at 97,641,760 bp
  • G to T, chromosome 4 at 21,931,557 bp
  • C to T, chromosome 4 at 133,211,179 bp
  • T to C, chromosome 4 at 148,562,392 bp
  • C to A, chromosome 4 at 154,006,242 bp
  • T to C, chromosome 4 at 155,875,208 bp
  • T to C, chromosome 5 at 23,499,333 bp
  • T to A, chromosome 5 at 107,345,144 bp
  • T to C, chromosome 5 at 112,355,044 bp
  • A to G, chromosome 5 at 129,769,367 bp
  • T to C, chromosome 6 at 32,206,121 bp
  • G to A, chromosome 6 at 90,662,878 bp
  • A to G, chromosome 7 at 5,058,097 bp
  • A to C, chromosome 7 at 10,170,745 bp
  • A to G, chromosome 7 at 28,091,818 bp
  • A to T, chromosome 7 at 30,265,263 bp
  • A to T, chromosome 7 at 48,312,192 bp
  • C to T, chromosome 7 at 56,184,961 bp
  • A to G, chromosome 7 at 87,438,014 bp
  • A to C, chromosome 7 at 97,509,678 bp
  • CGGCGGC to CGGCGGCGGGGGCGGC, chromosome 7 at 97,579,929 bp
  • T to A, chromosome 7 at 99,688,991 bp
  • A to T, chromosome 7 at 135,714,001 bp
  • T to A, chromosome 8 at 55,871,757 bp
  • T to A, chromosome 8 at 78,251,910 bp
  • T to C, chromosome 10 at 9,799,991 bp
  • A to C, chromosome 10 at 129,873,941 bp
  • A to C, chromosome 11 at 42,133,552 bp
  • T to A, chromosome 11 at 48,915,555 bp
  • A to T, chromosome 11 at 59,372,995 bp
  • T to C, chromosome 11 at 67,186,556 bp
  • A to G, chromosome 11 at 75,402,158 bp
  • T to A, chromosome 11 at 83,035,529 bp
  • T to C, chromosome 11 at 98,428,206 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • A to G, chromosome 11 at 102,895,748 bp
  • G to A, chromosome 11 at 106,778,970 bp
  • G to A, chromosome 12 at 112,601,553 bp
  • T to A, chromosome 13 at 67,413,130 bp
  • G to A, chromosome 13 at 76,147,767 bp
  • G to T, chromosome 13 at 112,851,555 bp
  • G to A, chromosome 14 at 26,911,909 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • A to G, chromosome 14 at 49,929,550 bp
  • G to A, chromosome 14 at 62,670,933 bp
  • T to C, chromosome 15 at 7,924,273 bp
  • C to A, chromosome 15 at 9,457,790 bp
  • T to C, chromosome 15 at 31,582,069 bp
  • A to T, chromosome 16 at 59,559,993 bp
  • T to C, chromosome 17 at 6,601,811 bp
  • C to A, chromosome 17 at 32,883,653 bp
  • G to A, chromosome 17 at 33,760,269 bp
  • G to A, chromosome 18 at 37,011,058 bp
  • A to G, chromosome 19 at 23,259,645 bp
  • A to G, chromosome 19 at 29,729,830 bp
  • A to G, chromosome 19 at 34,587,807 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5306 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042889-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.