Strain Name:
C57BL/6J-MtgxR5318Btlr/Mmmh
Stock Number:
042901-MU
Citation ID:
RRID:MMRRC_042901-MU
Other Names:
R5318 (G1), C57BL/6J-MtgxR5318Btlr
Major Collection:

Gene Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268281
Homologene: 6489
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Tm9sf4
Name: transmembrane 9 superfamily member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99237
Homologene: 21620
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms: Ku p70, Ku70, G22p1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14375
HGNC: HGNC:4055
Homologene: 37483
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Tbc1d15
Name: TBC1 domain family, member 15
Synonyms: 4432405K22Rik, Ly6dl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66687
VEGA: 10
Homologene: 11249
Tdrd3
Name: tudor domain containing 3
Synonyms: 4732418C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219249
Homologene: 12771
Snupn
Name: snurportin 1
Synonyms: 0610031A09Rik, Rnut1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66069
Homologene: 4166
Tcf4
Name: transcription factor 4
Synonyms: SEF-2, ITF-2, MITF-2B, MITF-2A, ME2, E2.2, TFE, E2-2, SEF2-1, ASP-I2, ITF-2b, 5730422P05Rik, bHLHb19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21413
Homologene: 2407
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Ap4m1
Name: adaptor-related protein complex AP-4, mu 1
Synonyms: 4930443L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11781
HGNC: HGNC:574
Homologene: 3467
Lrrtm4
Name: leucine rich repeat transmembrane neuronal 4
Synonyms: 7530419J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243499
Homologene: 11807
2300002M23Rik
Name: RIKEN cDNA 2300002M23 gene
Synonyms: emprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69542
Homologene: 49368
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233552
Homologene: 32741
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Cblb
Name: Casitas B-lineage lymphoma b
Synonyms: Cbl-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208650
VEGA: 16
HGNC: HGNC:1542
Homologene: 15856
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Vhl
Name: von Hippel-Lindau tumor suppressor
Synonyms: Vhlh, pVHL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22346
Homologene: 465
P2rx4
Name: purinergic receptor P2X, ligand-gated ion channel 4
Synonyms: P2X4, D5Ertd444e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18438
HGNC: HGNC:8535
Homologene: 1923
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17259
HGNC: HGNC:6995
Homologene: 48381
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Gpr75
Name: G protein-coupled receptor 75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237716
HGNC: HGNC:4526
Homologene: 4945
Grik3
Name: glutamate receptor, ionotropic, kainate 3
Synonyms: Glur-7, Glur7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14807
HGNC: HGNC:4581
Homologene: 73901
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Dnm3
Name: dynamin 3
Synonyms: B230343F03Rik, 9630020E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 103967
Homologene: 22906
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381852
Homologene: 115938
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: 5730592G18Rik, A730013O20Rik, C130038G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77521
Homologene: 78141
Or1x2
Name: olfactory receptor family 1 subfamily X member 2
Synonyms: F3, MOR126-1, GA_x6K02T2QP88-4411197-4410256, Olfr54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18354
Homologene: 115479
Cabs1
Name: calcium binding protein, spermatid specific 1
Synonyms: 4931407G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70977
Homologene: 13225
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: LOC382543, 4932411E22Rik, nmf9, mWAKE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 382543
Homologene: 34996
Dnase2b
Name: deoxyribonuclease II beta
Synonyms: DnaseIIb, Dlad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56629
Homologene: 1052
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Clip50, CLIP-170, 1110007I12Rik, 4631429H07Rik, Rsn, Clip 170, restin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56430
Homologene: 74455
Foxred2
Name: FAD-dependent oxidoreductase domain containing 2
Synonyms: LOC239554, A430097D04Rik, D15Bwg0759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239554
Homologene: 11800
Vmn1r201
Name: vomeronasal 1 receptor 201
Synonyms: V1ri4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171255
Homologene: 110880
Cel
Name: carboxyl ester lipase
Synonyms: BAL, 1810036E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Proca1
Name: protein interacting with cyclin A1
Synonyms: 4933404M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216974
Homologene: 51856
Dtx2
Name: deltex 2, E3 ubiquitin ligase
Synonyms: 2610524D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74198
Homologene: 56904
Bin3
Name: bridging integrator 3
Synonyms: 1700015F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57784
VEGA: 14
HGNC: HGNC:1054
Homologene: 5472
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76438
Homologene: 18745
Akr1b3
Name: aldo-keto reductase family 1, member B3 (aldose reductase)
Synonyms: Ahr-1, Ahr1, Aldor1, Aldr1, ALR2, AR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Or8d1
Name: olfactory receptor family 8 subfamily D member 1
Synonyms: MTPCR09, MOR171-9, GA_x6K02T2PVTD-32550930-32551856, Olfr26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Ccdc153
Name: coiled-coil domain containing 153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270150
VEGA: 9
Homologene: 26818
Gsg1l2
Name: GSG1-like 2
Synonyms: Gm12302
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544792
Homologene: 132038
H2-Q4
Name: histocompatibility 2, Q region locus 4
Synonyms: Qb-1, Qat-4, Qb1, Qa4, Qa-4, H-2Q4, H2-Gs10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15015
Homologene: 128352
Or8s2
Name: olfactory receptor family 8 subfamily S member 2
Synonyms: GA_x6K02T2NBG7-5351896-5352825, MOR160-1, Olfr283
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 259038
Homologene: 64944
Gm5617
Name: predicted gene 5617
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434402
VEGA: 9
Homologene: 49583
Anapc15
Name: anaphase promoting complex C subunit 15
Synonyms: 6330414C15Rik, 3200002M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75430
Homologene: 87047
Gm38394
Name: predicted gene, 38394
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm21830
Name: predicted gene, 21830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
A730045E13Rik
Name: RIKEN cDNA A730045E13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 118,844,470 bp
  • T to A, chromosome 1 at 128,304,372 bp
  • A to G, chromosome 1 at 133,658,115 bp
  • G to A, chromosome 1 at 162,011,807 bp
  • T to C, chromosome 2 at 28,557,708 bp
  • A to G, chromosome 2 at 49,671,828 bp
  • A to T, chromosome 2 at 67,432,814 bp
  • T to A, chromosome 2 at 153,187,656 bp
  • A to C, chromosome 2 at 166,873,971 bp
  • C to A, chromosome 3 at 146,582,455 bp
  • A to G, chromosome 4 at 125,694,136 bp
  • A to G, chromosome 5 at 87,980,566 bp
  • G to A, chromosome 5 at 122,719,148 bp
  • G to A, chromosome 5 at 123,613,084 bp
  • T to A, chromosome 5 at 136,012,100 bp
  • T to C, chromosome 5 at 138,176,169 bp
  • T to A, chromosome 5 at 148,076,572 bp
  • A to G, chromosome 6 at 34,310,573 bp
  • A to G, chromosome 6 at 80,022,512 bp
  • G to T, chromosome 6 at 113,629,571 bp
  • T to C, chromosome 6 at 120,366,611 bp
  • T to C, chromosome 6 at 135,733,918 bp
  • C to A, chromosome 7 at 17,915,667 bp
  • T to A, chromosome 7 at 30,715,329 bp
  • A to T, chromosome 7 at 99,453,027 bp
  • C to T, chromosome 7 at 101,898,603 bp
  • A to T, chromosome 7 at 118,160,204 bp
  • T to C, chromosome 8 at 24,185,127 bp
  • A to T, chromosome 8 at 70,166,843 bp
  • A to T, chromosome 9 at 16,376,629 bp
  • C to T, chromosome 9 at 38,855,448 bp
  • A to T, chromosome 9 at 44,245,765 bp
  • T to A, chromosome 9 at 48,495,911 bp
  • T to C, chromosome 9 at 56,957,061 bp
  • A to G, chromosome 9 at 113,659,812 bp
  • T to G, chromosome 10 at 11,166,557 bp
  • A to T, chromosome 10 at 115,208,969 bp
  • G to T, chromosome 11 at 30,892,459 bp
  • T to C, chromosome 11 at 51,027,593 bp
  • G to T, chromosome 11 at 67,782,521 bp
  • T to A, chromosome 11 at 78,201,857 bp
  • A to G, chromosome 11 at 89,391,928 bp
  • A to G, chromosome 12 at 79,270,850 bp
  • A to T, chromosome 12 at 88,176,228 bp
  • T to C, chromosome 12 at 103,653,962 bp
  • T to C, chromosome 13 at 22,474,922 bp
  • T to A, chromosome 14 at 33,078,343 bp
  • A to G, chromosome 14 at 70,134,512 bp
  • T to C, chromosome 14 at 87,477,463 bp
  • T to C, chromosome 15 at 77,952,398 bp
  • T to C, chromosome 15 at 82,037,507 bp
  • A to G, chromosome 15 at 98,378,642 bp
  • T to G, chromosome 16 at 49,110,471 bp
  • A to T, chromosome 16 at 52,186,198 bp
  • G to A, chromosome 17 at 35,383,311 bp
  • G to A, chromosome 17 at 35,567,986 bp
  • G to T, chromosome 17 at 49,994,458 bp
  • T to C, chromosome 18 at 69,465,430 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5318 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042901-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.