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Strain Name:
C57BL/6J-MtgxR5335Btlr/Mmmh
Stock Number:
042916-MU
Citation ID:
RRID:MMRRC_042916-MU
Other Names:
R5335 (G1), C57BL/6J-MtgxR5335Btlr
Major Collection:

Strain Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77569
Homologene: 18953
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Epc2
Name: enhancer of polycomb homolog 2
Synonyms: D2Ertd694e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227867
Homologene: 32274
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 2810004D21Rik, 4632404O06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Epha8
Name: Eph receptor A8
Synonyms: EphA8, Hek3, Eek
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Atxn10
Name: ataxin 10
Synonyms: TEG-169, E46, Sca10, Tex169
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54138
VEGA: 15
Homologene: 40858
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAFII150, CIF150, TAF2B, 4732460C16Rik, 150kDa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Dis3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms: 2810028N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72662
VEGA: 14
Homologene: 6910
Kcnip2
Name: Kv channel-interacting protein 2
Synonyms: KChIP2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 80906
Homologene: 23710
Pi4k2b
Name: phosphatidylinositol 4-kinase type 2 beta
Synonyms: 4933409G22Rik, 2610042N09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67073
Homologene: 32405
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: NCU-G1, 0610031J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56700
Homologene: 10562
Cachd1
Name: cache domain containing 1
Synonyms: 1190007F10Rik, Vwcd1, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Mplkipl1
Name: M-phase specific PLK1 intereacting protein like 1
Synonyms: Gm7102
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 633057
F2
Name: coagulation factor II
Synonyms: prothrombin, Cf-2, Cf2, FII, thrombin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14061
HGNC: HGNC:3535
Homologene: 426
Rnf168
Name: ring finger protein 168
Synonyms: 3110001H15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70238
Homologene: 87044
Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Synonyms: prohormone convertase 2, Nec-2, Phpp-2, Nec2, PC2, SPC2, 6330411F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18549
HGNC: HGNC:8744
Homologene: 37640
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Taf5l
Name: TATA-box binding protein associated factor 5 like
Synonyms: 1110005N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102162
Homologene: 8676
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100066
HGNC: HGNC:2634
Homologene: 133819
Gm10306
Name: predicted gene 10306
Type: Gene
Species: Mouse
Chromosome: 4
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 211223
Homologene: 129606
Or5j1
Name: olfactory receptor family 5 subfamily J member 1
Synonyms: GA_x6K02T2Q125-48541463-48540525, MOR172-8_p, MOR172-6, Olfr1106
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258747
Homologene: 27251
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: Glur-5, Glur5, D16Ium24, A830007B11Rik, D16Ium24e, Glurbeta1, GluK5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Or1j17
Name: olfactory receptor family 1 subfamily J member 17
Synonyms: GA_x6K02T2NLDC-33382467-33383396, MOR136-11, Olfr346
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258940
Homologene: 133616
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Or1x2
Name: olfactory receptor family 1 subfamily X member 2
Synonyms: F3, MOR126-1, GA_x6K02T2QP88-4411197-4410256, Olfr54
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18354
Homologene: 115479
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107141
Homologene: 137231
Or52s19
Name: olfactory receptor family 52 subfamily S member 19
Synonyms: GA_x6K02T2PBJ9-6068534-6067590, MOR24-3, Olfr601
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258311
Homologene: 64851
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, 6330569M22Rik, Fam40a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229707
Homologene: 35064
Gemin6
Name: gem nuclear organelle associated protein 6
Synonyms: 2610019B15Rik, 2810470M17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67242
Homologene: 11711
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72046
Homologene: 69243
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382407
VEGA: 10
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140577
Homologene: 8967
Opcml
Name: opioid binding protein/cell adhesion molecule-like
Synonyms: Obcam, LOC235104, 2900075O15Rik, B930023M13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330908
HGNC: HGNC:8143
Homologene: 55663
Vmn1r197
Name: vomeronasal 1 receptor 197
Synonyms: V1rh21
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171278
Homologene: 110880
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Or2ag18
Name: olfactory receptor family 2 subfamily AG member 18
Synonyms: GA_x6K02T2PBJ9-9184187-9183237, MOR283-4, Olfr700
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258593
Homologene: 64895
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: Tim44, Mimt44, D8Ertd118e, 0710005E20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21856
Homologene: 4631
Or2b6
Name: olfactory receptor family 2 subfamily B member 6
Synonyms: GA_x6K02T2QHY8-11597382-11598323, MOR256-11, Olfr11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Mtcl3
Name: MTCL family member 3
Synonyms: 6330407J23Rik, Soga3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67412
VEGA: 10
Homologene: 28227
Or51f1d
Name: olfactory receptor family 51 subfamily F member 1D
Synonyms: GA_x6K02T2PBJ9-5762668-5763618, MOR14-6, Olfr583
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258752
Homologene: 133721
Eif3i
Name: eukaryotic translation initiation factor 3, subunit I
Synonyms: D4Ertd632e, 36kDa, Eif3s2, TRIP-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54709
HGNC: HGNC:3272
Homologene: 2786
Ptpn18
Name: protein tyrosine phosphatase, non-receptor type 18
Synonyms: HSCF, FLP1, Ptpk1, PTP-K1, PTP-HSCF
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19253
HGNC: HGNC:9649
Homologene: 74971
Esd
Name: esterase D/formylglutathione hydrolase
Synonyms: Es-10, Esd, Es10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13885
HGNC: HGNC:3465
Homologene: 55623
Ube2r2
Name: ubiquitin-conjugating enzyme E2R 2
Synonyms: Cdc34b, Ubc3b, 1200003M11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67615
Homologene: 3210
Tspan4
Name: tetraspanin 4
Synonyms: Tspan-4, novel antigen 2, NAG-2, D130042I01Rik, Tm4sf7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64540
Homologene: 2453
Tcp10b
Name: t-complex protein 10b
Synonyms: T66B-a, D17Leh66ba, D17Leh66B, Tcp-10b, Tcp-10bt
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21462
Homologene: 83254
Bcas2
Name: BCAS2 pre-mRNA processing factor
Synonyms: 6430539P16Rik, C76366, breast carcinoma amplified sequence 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68183
HGNC: HGNC:975
Homologene: 4291
Vsig10l2
Name: V-set and immunoglobulin domain containing 10 like 2
Synonyms: LOC382069, Gm1113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 115487164
Zfp853
Name: zinc finger protein 853
Synonyms: LOC330230
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330230
Gm28529
Name: predicted gene 28529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
C2cd6b
Name: C2 calcium dependent domain containing 6B
Synonyms: Gm33589, Als2cr11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
2010003K11Rik
Name: RIKEN cDNA 2010003K11 gene
Synonyms: Faci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69861
VEGA: 19
Homologene: 52832
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,463,178 bp
  • T to A, chromosome 1 at 59,004,234 bp
  • C to G, chromosome 1 at 85,589,118 bp
  • A to T, chromosome 1 at 166,497,453 bp
  • T to C, chromosome 1 at 173,926,919 bp
  • A to T, chromosome 2 at 36,688,094 bp
  • A to G, chromosome 2 at 49,513,230 bp
  • T to G, chromosome 2 at 87,049,165 bp
  • T to C, chromosome 2 at 91,634,932 bp
  • A to T, chromosome 2 at 143,546,640 bp
  • G to T, chromosome 3 at 88,326,655 bp
  • A to G, chromosome 3 at 103,175,635 bp
  • G to A, chromosome 3 at 107,624,671 bp
  • A to G, chromosome 3 at 114,095,240 bp
  • T to C, chromosome 4 at 32,818,651 bp
  • T to C, chromosome 4 at 41,190,846 bp
  • C to A, chromosome 4 at 94,556,807 bp
  • T to C, chromosome 4 at 96,307,352 bp
  • G to A, chromosome 4 at 100,968,085 bp
  • T to C, chromosome 4 at 129,595,186 bp
  • A to T, chromosome 4 at 136,931,935 bp
  • A to G, chromosome 5 at 52,741,756 bp
  • A to T, chromosome 5 at 66,881,957 bp
  • A to T, chromosome 5 at 109,286,807 bp
  • T to A, chromosome 5 at 143,288,563 bp
  • T to C, chromosome 7 at 28,089,734 bp
  • A to C, chromosome 7 at 103,051,535 bp
  • A to C, chromosome 7 at 103,358,522 bp
  • A to C, chromosome 7 at 106,805,734 bp
  • A to G, chromosome 7 at 141,489,615 bp
  • A to T, chromosome 8 at 4,266,814 bp
  • T to A, chromosome 8 at 18,689,061 bp
  • A to G, chromosome 8 at 124,003,651 bp
  • A to G, chromosome 9 at 28,675,325 bp
  • T to A, chromosome 9 at 35,516,442 bp
  • T to C, chromosome 9 at 82,900,756 bp
  • A to T, chromosome 10 at 29,147,106 bp
  • G to A, chromosome 10 at 99,445,147 bp
  • C to T, chromosome 10 at 121,785,377 bp
  • T to C, chromosome 11 at 5,717,754 bp
  • A to C, chromosome 11 at 51,027,334 bp
  • T to C, chromosome 11 at 118,112,514 bp
  • A to C, chromosome 13 at 21,638,779 bp
  • T to C, chromosome 13 at 22,328,191 bp
  • A to G, chromosome 14 at 26,879,738 bp
  • A to G, chromosome 14 at 54,986,563 bp
  • G to T, chromosome 14 at 74,742,113 bp
  • A to G, chromosome 14 at 99,097,653 bp
  • G to A, chromosome 15 at 55,045,740 bp
  • A to G, chromosome 15 at 85,336,584 bp
  • C to T, chromosome 16 at 32,298,584 bp
  • CGG to CGGG, chromosome 16 at 87,923,194 bp
  • T to C, chromosome 17 at 13,063,067 bp
  • T to C, chromosome 17 at 80,225,755 bp
  • C to T, chromosome 18 at 6,490,689 bp
  • A to T, chromosome 18 at 7,294,566 bp
  • G to T, chromosome 18 at 37,267,255 bp
  • A to G, chromosome 19 at 4,498,264 bp
  • A to T, chromosome 19 at 40,090,616 bp
  • C to A, chromosome 19 at 45,794,246 bp
  • C to T, chromosome 19 at 61,175,926 bp
  • A to T, chromosome Y at 2,663,647 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5335 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042916-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.