Strain Name:
C57BL/6J-MtgxR5353Btlr/Mmmh
Stock Number:
042932-MU
Citation ID:
RRID:MMRRC_042932-MU
Other Names:
R5353 (G1), C57BL/6J-MtgxR5353Btlr
Major Collection:

Strain Information

Ptpn5
Name: protein tyrosine phosphatase, non-receptor type 5
Synonyms: Step
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19259
HGNC: HGNC:9657
Homologene: 8423
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, C330023D02Rik, 4931431C02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Fmn2
Name: formin 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54418
Homologene: 137334
Ppm1b
Name: protein phosphatase 1B, magnesium dependent, beta isoform
Synonyms: PP2CB
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19043
VEGA: 17
HGNC: HGNC:9276
Homologene: 2027
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75991
Homologene: 18952
Anln
Name: anillin, actin binding protein
Synonyms: Scraps, 2900037I21Rik, 1110037A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, Casc5, 5730505K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Spred2
Name: sprouty-related EVH1 domain containing 2
Synonyms: Spred-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114716
Homologene: 24918
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: RPTPgamma, 5430405N12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: Mypt1, 5730577I22Rik, D10Ertd625e, 1200015F06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Cbl
Name: Casitas B-lineage lymphoma
Synonyms: c-Cbl, 4732447J05Rik, Cbl-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12402
HGNC: HGNC:1541
Homologene: 3802
Cog7
Name: component of oligomeric golgi complex 7
Synonyms: 5630400E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233824
Homologene: 33431
Psmc5
Name: protease (prosome, macropain) 26S subunit, ATPase 5
Synonyms: mSUG1, Rpt6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19184
HGNC: HGNC:9552
Homologene: 2098
Cdc45
Name: cell division cycle 45
Synonyms: Cdc45l
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12544
HGNC: HGNC:1739
Homologene: 2616
Aprt
Name: adenine phosphoribosyl transferase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11821
HGNC: HGNC:626
Homologene: 413
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, Fath, 2310038E12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Selenot
Name: selenoprotein T
Synonyms: SelT, Selt, 5730408P04Rik, 2810407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69227
Homologene: 32304
Arid3b
Name: AT-rich interaction domain 3B
Synonyms: Bdp, Dri2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56380
Homologene: 4721
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Cenpl
Name: centromere protein L
Synonyms: 2610300B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70454
Homologene: 19618
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, A230065J02Rik, Ugcgl2, 1810064L21Rik, 3110027P15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Dnai3
Name: dynein axonemal intermediate chain 3
Synonyms: 4931433A13Rik, IC140, Wdr63, Ida7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242253
Homologene: 44922
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Yipf2
Name: Yip1 domain family, member 2
Synonyms: 1300010K09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74766
VEGA: 9
Homologene: 23430
Or4c111
Name: olfactory receptor family 4 subfamily C member 111
Synonyms: GA_x6K02T2Q125-50494588-50493653, Olfr1216, MOR233-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258895
Homologene: 74241
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54672
Homologene: 18129
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: ADAM-TS1, METH1, ADAMTS-1, METH-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Zscan12
Name: zinc finger and SCAN domain containing 12
Synonyms: Zfp96
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22758
Homologene: 86980
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: Hisppd2a, B430315C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: 2900022I03Rik, MDC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Synonyms: M3R, Chrm-3, muscarinic acetylcholine receptor 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12671
HGNC: HGNC:1952
Homologene: 20191
Eri2
Name: exoribonuclease 2
Synonyms: Exod1, 4933424N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71151
Homologene: 12383
Nr1d2
Name: nuclear receptor subfamily 1, group D, member 2
Synonyms: RVR, Rev-erb beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 353187
HGNC: HGNC:7963
Homologene: 3763
Or52b2
Name: olfactory receptor family 52 subfamily B member 2
Synonyms: GA_x6K02T2PBJ9-7966695-7965727, MOR31-6, Olfr691
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259063
Homologene: 17483
Rbbp9
Name: retinoblastoma binding protein 9, serine hydrolase
Synonyms: Bog
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26450
HGNC: HGNC:9892
Homologene: 4816
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Hdac9
Name: histone deacetylase 9
Synonyms: Hdac7b, Mitr, D030072B18Rik, HDRP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 79221
Homologene: 128578
Lztfl1
Name: leucine zipper transcription factor-like 1
Synonyms: 6130400H19Rik, 5530402H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93730
HGNC: HGNC:6741
Homologene: 41368
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ipr1, 5830484A20Rik, 52kDa, 5031415C07Rik, Ifi75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Prpf38b
Name: PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
Synonyms: 1110021E09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66921
Homologene: 9986
Fank1
Name: fibronectin type 3 and ankyrin repeat domains 1
Synonyms: 1700007B22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66930
Homologene: 12055
Nkd2
Name: naked cuticle 2
Synonyms: 2210403L10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72293
Homologene: 12459
Crebzf
Name: CREB/ATF bZIP transcription factor
Synonyms: 1110034C16Rik, 6330417B10Rik, LAZipII, LAZip, Zf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233490
Homologene: 10926
Tas2r109
Name: taste receptor, type 2, member 109
Synonyms: mt2r62, T2R09, Tas2r9, mGR09
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387343
Homologene: 87292
Surf1
Name: surfeit gene 1
Synonyms: 0610010F23Rik, Surf-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20930
Homologene: 2387
Lsm8
Name: LSM8 homolog, U6 small nuclear RNA associated
Synonyms: Lsm8, 2010003I05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76522
Homologene: 9419
Taco1
Name: translational activator of mitochondrially encoded cytochrome c oxidase I
Synonyms: Ccdc44, 2310066I18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70207
Homologene: 39079
Gm13194
Name: predicted gene 13194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 115489434
Homologene: 138679
Gm13981
Name: predicted gene 13981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108168832
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 85,589,120 bp
  • A to G, chromosome 1 at 93,325,476 bp
  • C to T, chromosome 1 at 140,426,901 bp
  • C to T, chromosome 1 at 150,445,924 bp
  • C to T, chromosome 1 at 161,083,171 bp
  • G to T, chromosome 1 at 174,503,006 bp
  • A to T, chromosome 2 at 4,942,201 bp
  • T to C, chromosome 2 at 26,914,192 bp
  • A to G, chromosome 2 at 89,013,755 bp
  • T to C, chromosome 2 at 117,055,947 bp
  • A to G, chromosome 2 at 119,070,983 bp
  • A to C, chromosome 2 at 121,311,720 bp
  • T to C, chromosome 2 at 144,543,821 bp
  • T to C, chromosome 3 at 58,585,966 bp
  • T to C, chromosome 3 at 108,904,684 bp
  • A to G, chromosome 3 at 146,044,836 bp
  • A to G, chromosome 4 at 143,571,237 bp
  • C to A, chromosome 5 at 8,090,182 bp
  • T to C, chromosome 5 at 72,974,628 bp
  • A to G, chromosome 6 at 132,980,631 bp
  • T to A, chromosome 7 at 47,081,894 bp
  • G to A, chromosome 7 at 90,443,414 bp
  • A to G, chromosome 7 at 105,337,117 bp
  • T to A, chromosome 7 at 107,794,424 bp
  • A to G, chromosome 7 at 119,785,612 bp
  • A to C, chromosome 7 at 121,941,247 bp
  • A to G, chromosome 7 at 133,876,903 bp
  • G to T, chromosome 8 at 45,036,131 bp
  • A to T, chromosome 8 at 95,035,928 bp
  • A to T, chromosome 8 at 122,575,408 bp
  • A to G, chromosome 9 at 21,591,932 bp
  • A to T, chromosome 9 at 21,814,786 bp
  • G to T, chromosome 9 at 22,360,517 bp
  • A to G, chromosome 9 at 44,173,323 bp
  • G to T, chromosome 9 at 57,795,037 bp
  • G to T, chromosome 9 at 78,710,239 bp
  • G to A, chromosome 9 at 105,667,938 bp
  • G to T, chromosome 9 at 108,544,965 bp
  • A to G, chromosome 9 at 123,709,614 bp
  • T to C, chromosome 10 at 43,973,665 bp
  • T to G, chromosome 10 at 108,261,216 bp
  • A to G, chromosome 11 at 20,018,155 bp
  • G to A, chromosome 11 at 69,396,582 bp
  • G to A, chromosome 11 at 106,072,713 bp
  • G to T, chromosome 11 at 106,261,501 bp
  • A to T, chromosome 12 at 16,688,566 bp
  • G to A, chromosome 12 at 34,393,393 bp
  • A to G, chromosome 13 at 9,878,557 bp
  • T to C, chromosome 13 at 21,364,008 bp
  • T to C, chromosome 13 at 73,821,438 bp
  • T to A, chromosome 14 at 11,554,235 bp
  • A to G, chromosome 14 at 18,222,125 bp
  • A to G, chromosome 14 at 119,081,770 bp
  • T to C, chromosome 15 at 4,917,178 bp
  • A to T, chromosome 15 at 76,602,571 bp
  • C to T, chromosome 16 at 18,795,897 bp
  • T to A, chromosome 16 at 85,802,608 bp
  • T to C, chromosome 17 at 84,994,109 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • A to G, chromosome 18 at 61,801,399 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5353 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042932-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.