Strain Name:
C57BL/6J-MtgxR5376Btlr/Mmmh
Stock Number:
042952-MU
Citation ID:
RRID:MMRRC_042952-MU
Other Names:
R5376 (G1), C57BL/6J-MtgxR5376Btlr
Major Collection:

Gene Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170750
Homologene: 6424
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74493
Homologene: 11890
Nfyc
Name: nuclear transcription factor-Y gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18046
HGNC: HGNC:7806
Homologene: 7440
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73274
Homologene: 11292
Kif15
Name: kinesin family member 15
Synonyms: N-10 kinesin, HKLP2, 3930402I10Rik, 3110023M17Rik, Knsl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Otud7b
Name: OTU domain containing 7B
Synonyms: 4930463P07Rik, 2900060B22Rik, Za20d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229603
Homologene: 10624
Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Synonyms: E030015G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208643
HGNC: HGNC:3296
Homologene: 110725
Golga3
Name: golgi autoantigen, golgin subfamily a, 3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Eef1d
Name: eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Synonyms: 5730529A16Rik, 1700026P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66656
HGNC: HGNC:3211
Homologene: 23404
Cnnm3
Name: cyclin M3
Synonyms: Acdp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94218
HGNC: HGNC:104
Homologene: 23029
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Ppp2r1b
Name: protein phosphatase 2, regulatory subunit A, beta
Synonyms: 2410091N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73699
HGNC: HGNC:9303
Homologene: 70244
Fcrl6
Name: Fc receptor-like 6
Synonyms: FcRH6, ENSMUSG00000070504, moFcRH6, mIFGP6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 677296
Homologene: 88414
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Dennd4b
Name: DENN/MADD domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229541
Homologene: 28281
Abcc2
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Psg26
Name: pregnancy-specific glycoprotein 26
Synonyms: cea14, EG574429
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 574429
Homologene: 110989
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 3110007G05Rik, 1700084G18Rik, 2310039H16Rik, B130050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213027
Homologene: 134635
Txndc15
Name: thioredoxin domain containing 15
Synonyms: 2310047H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69672
VEGA: 13
Homologene: 32594
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Cd300c
Name: CD300C molecule
Synonyms: Clm6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 387565
Homologene: 74580
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Coa8
Name: cytochrome c oxidase assembly factor 8
Synonyms: 1700081D05Rik, Apop-1, 2810002N01Rik, Apopt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68020
Homologene: 12225
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230612
Homologene: 17081
Olfr55
Name: olfactory receptor 55
Synonyms: IF6, MOR267-17, GA_x6K02T2MG8L-16493-15546, MOR267-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100038859
HGNC: HGNC:8172
Homologene: 110515
Dsc1
Name: desmocollin 1
Synonyms: Dsc1b, Dsc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Olfr1467
Name: olfactory receptor 1467
Synonyms: GA_x6K02T2RE5P-3695694-3696620, MOR202-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258686
Homologene: 133888
Potea
Name: POTE ankyrin domain family member A
Synonyms: 4930430A15Rik, A26c3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67575
Homologene: 69410
Csn3
Name: casein kappa
Synonyms: CSN10, Csnk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Zfp493
Name: zinc finger protein 493
Synonyms: 2900054J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72958
Psg25
Name: pregnancy-specific glycoprotein 25
Synonyms: cea13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114868
Homologene: 110989
Plekhg2
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms: Clg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101497
Homologene: 16341
Olfr678
Name: olfactory receptor 678
Synonyms: GA_x6K02T2PBJ9-7698491-7699432, MOR32-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258753
Homologene: 27254
Kdelr3
Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105785
VEGA: 15
HGNC: HGNC:6306
Homologene: 68533
Tex37
Name: testis expressed 37
Synonyms: 1700011F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74221
Homologene: 17643
Igkv12-46
Name: immunoglobulin kappa variable 12-46
Synonyms: Gm16849
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 692245
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,520,678 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • G to A, chromosome 1 at 172,599,280 bp
  • T to C, chromosome 2 at 111,215,599 bp
  • C to T, chromosome 3 at 90,278,056 bp
  • T to A, chromosome 3 at 96,153,524 bp
  • A to T, chromosome 4 at 111,893,217 bp
  • T to C, chromosome 4 at 120,761,661 bp
  • T to A, chromosome 5 at 87,928,237 bp
  • T to C, chromosome 5 at 110,220,945 bp
  • A to C, chromosome 6 at 69,764,536 bp
  • C to A, chromosome 6 at 70,913,482 bp
  • C to T, chromosome 6 at 140,551,144 bp
  • A to T, chromosome 7 at 18,480,105 bp
  • A to T, chromosome 7 at 18,526,535 bp
  • G to A, chromosome 7 at 28,362,669 bp
  • A to T, chromosome 7 at 105,070,357 bp
  • T to C, chromosome 8 at 4,210,770 bp
  • C to T, chromosome 9 at 50,866,928 bp
  • T to A, chromosome 9 at 122,993,971 bp
  • T to C, chromosome 10 at 10,346,563 bp
  • A to C, chromosome 11 at 114,956,271 bp
  • G to C, chromosome 11 at 120,012,034 bp
  • A to G, chromosome 12 at 111,730,058 bp
  • T to G, chromosome 13 at 55,718,219 bp
  • T to C, chromosome 13 at 67,786,318 bp
  • T to C, chromosome 13 at 95,026,146 bp
  • T to C, chromosome 13 at 109,772,644 bp
  • T to C, chromosome 13 at 111,426,642 bp
  • A to T, chromosome 14 at 103,242,432 bp
  • C to T, chromosome 14 at 118,911,393 bp
  • T to A, chromosome 15 at 25,701,754 bp
  • G to T, chromosome 15 at 75,903,189 bp
  • T to A, chromosome 15 at 79,525,860 bp
  • T to A, chromosome 16 at 20,683,827 bp
  • A to T, chromosome 17 at 33,176,647 bp
  • T to G, chromosome 18 at 20,088,446 bp
  • A to T, chromosome 19 at 13,365,398 bp
  • T to A, chromosome 19 at 36,880,475 bp
  • A to G, chromosome 19 at 37,916,400 bp
  • A to T, chromosome 19 at 43,829,900 bp
  • G to T, chromosome 19 at 53,006,344 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5376 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042952-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.