Strain Name:
C57BL/6J-MtgxR5391Btlr/Mmmh
Stock Number:
042963-MU
Citation ID:
RRID:MMRRC_042963-MU
Other Names:
R5391 (G1), C57BL/6J-MtgxR5391Btlr
Major Collection:

Gene Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Nfia
Name: nuclear factor I/A
Synonyms: 1110047K16Rik, NF1-A, 9430022M17Rik, NF1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18027
HGNC: HGNC:7784
Homologene: 4086
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Tbce
Name: tubulin-specific chaperone E
Synonyms: 2610206D02Rik, C530005D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70430
Homologene: 37744
Ctdspl2
Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
Synonyms: D2Ertd485e, SCP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329506
Homologene: 32311
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Rnf169
Name: ring finger protein 169
Synonyms: 2900057K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108937
Homologene: 47510
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Vps26a
Name: VPS26 retromer complex component A
Synonyms: HB58, H beta 58, Vps26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 30930
VEGA: 10
Homologene: 68420
Tmem87a
Name: transmembrane protein 87A
Synonyms: A930025J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211499
Homologene: 9165
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: C3G, 4932418O06Rik, Grf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: Sin3, mSin3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20466
Homologene: 32124
Zkscan1
Name: zinc finger with KRAB and SCAN domains 1
Synonyms: 9230118B16Rik, 5930429A01Rik, KOX18, 9130423L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74570
Homologene: 34523
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52357
Homologene: 32618
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: vzg-1, LPA1, Kdt2, Gpcr26, Edg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14745
HGNC: HGNC:3166
Homologene: 1072
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: CPTI, L-CPT I, Cpt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Six6
Name: sine oculis-related homeobox 6
Synonyms: Six9, Optx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20476
Homologene: 7220
Elac2
Name: elaC ribonuclease Z 2
Synonyms: 1110017O07Rik, D11Wsu80e, tRNase Z(L)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68626
Homologene: 6403
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Ptov1
Name: prostate tumor over expressed gene 1
Synonyms: 1110030G05Rik, Gcap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 84113
HGNC: HGNC:9632
Homologene: 9687
Zbtb44
Name: zinc finger and BTB domain containing 44
Synonyms: 6030404E16Rik, Btbd15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235132
VEGA: 9
Homologene: 18221
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72685
Homologene: 8865
Usf3
Name: upstream transcription factor family member 3
Synonyms: LOC207806, LOC385650, 5530400K22Rik, Gm608
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207806
Homologene: 19504
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: IL-12RB2, Ifnm, A930027I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Actl7a
Name: actin-like 7a
Synonyms: Tact2, t-actin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11470
HGNC: HGNC:161
Homologene: 7613
Ankrd33b
Name: ankyrin repeat domain 33B
Synonyms: 0610012A05Rik, 5730557B15Rik, 3021401C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67434
Homologene: 12362
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: Mdr1, Mdr1b, mdr, Pgy1, Pgy-1, Abcb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18669
Homologene: 69084
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b288Clo, b2b1702Clo, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Olfr215
Name: olfactory receptor 215
Synonyms: GA_x54KRFPKN04-58217732-58216800, MOR119-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258438
Homologene: 133693
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624845
Homologene: 83483
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030018G17Rik, 1110018I21Rik, Tns, E030037J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21961
Homologene: 11219
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Ccdc105
Name: coiled-coil domain containing 105
Synonyms: 4931413A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Olfr1453
Name: olfactory receptor 1453
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258695
Homologene: 120159
Ccs
Name: copper chaperone for superoxide dismutase
Synonyms: CCS, Ccsd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12460
VEGA: 19
HGNC: HGNC:1613
Homologene: 3762
Zfp800
Name: zinc finger protein 800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 627049
Homologene: 18529
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: MTGR2, ETO-2, A630044F12Rik, Eto2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Gdf9
Name: growth differentiation factor 9
Synonyms: Gdf-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14566
HGNC: HGNC:4224
Homologene: 3851
Zfp935
Name: zinc finger protein 935
Synonyms: 8430426H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71508
VEGA: 13
Zkscan14
Name: zinc finger with KRAB and SCAN domains 14
Synonyms: 2810437E14Rik, 2310046C23Rik, Zfp99
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67235
Homologene: 11342
Zfp825
Name: zinc finger protein 825
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 235956
Pcdhgb6
Name: protocadherin gamma subfamily B, 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93703
HGNC: HGNC:8713
Homologene: 49573
Gm2396
Name: predicted gene 2396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 105245043
Gm16551
Name: predicted gene 16551
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100503019
Tmem176a
Name: transmembrane protein 176A
Synonyms: 0610011I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66058
Homologene: 10224
Mir6898
Name: microRNA 6898
Synonyms: mmu-mir-6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102465541
VEGA: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 36,348,686 bp
  • A to T, chromosome 1 at 73,990,409 bp
  • A to G, chromosome 2 at 26,440,032 bp
  • T to A, chromosome 2 at 29,737,965 bp
  • A to G, chromosome 2 at 120,362,877 bp
  • G to A, chromosome 2 at 122,004,148 bp
  • G to A, chromosome 3 at 104,802,533 bp
  • A to G, chromosome 4 at 56,743,661 bp
  • A to G, chromosome 4 at 58,486,902 bp
  • A to G, chromosome 4 at 97,783,301 bp
  • T to C, chromosome 4 at 101,628,158 bp
  • A to T, chromosome 4 at 149,659,131 bp
  • G to A, chromosome 5 at 8,805,481 bp
  • T to A, chromosome 5 at 138,097,101 bp
  • T to C, chromosome 5 at 145,195,794 bp
  • A to T, chromosome 6 at 28,242,993 bp
  • T to C, chromosome 6 at 48,844,696 bp
  • T to C, chromosome 6 at 67,292,420 bp
  • T to C, chromosome 6 at 116,582,847 bp
  • G to A, chromosome 7 at 25,340,289 bp
  • T to C, chromosome 7 at 44,863,584 bp
  • A to T, chromosome 7 at 99,935,160 bp
  • C to T, chromosome 7 at 120,090,076 bp
  • A to T, chromosome 8 at 47,863,871 bp
  • A to G, chromosome 8 at 86,017,468 bp
  • G to A, chromosome 8 at 93,976,048 bp
  • G to A, chromosome 8 at 122,633,395 bp
  • A to G, chromosome 9 at 31,053,305 bp
  • G to A, chromosome 9 at 57,105,673 bp
  • A to G, chromosome 9 at 74,849,180 bp
  • A to T, chromosome 9 at 88,917,615 bp
  • G to T, chromosome 9 at 113,691,518 bp
  • A to G, chromosome 10 at 62,456,747 bp
  • G to A, chromosome 10 at 78,752,854 bp
  • A to G, chromosome 10 at 79,356,657 bp
  • T to C, chromosome 11 at 53,433,797 bp
  • A to G, chromosome 11 at 64,994,294 bp
  • T to A, chromosome 11 at 115,985,068 bp
  • T to A, chromosome 12 at 72,941,701 bp
  • A to C, chromosome 12 at 119,170,741 bp
  • T to C, chromosome 13 at 14,005,965 bp
  • G to T, chromosome 13 at 62,454,818 bp
  • T to C, chromosome 13 at 74,480,546 bp
  • T to A, chromosome 14 at 21,624,816 bp
  • T to C, chromosome 15 at 31,325,206 bp
  • G to T, chromosome 15 at 64,094,052 bp
  • A to G, chromosome 15 at 81,706,446 bp
  • C to A, chromosome 15 at 101,951,828 bp
  • T to A, chromosome 16 at 44,217,463 bp
  • T to C, chromosome 17 at 80,275,081 bp
  • T to G, chromosome 18 at 37,742,587 bp
  • A to G, chromosome 19 at 3,349,260 bp
  • C to G, chromosome 19 at 4,833,482 bp
  • T to G, chromosome 19 at 6,071,033 bp
  • G to T, chromosome 19 at 13,027,786 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5391 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042963-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.