Strain Name:
C57BL/6J-MtgxR5393Btlr/Mmmh
Stock Number:
042965-MU
Citation ID:
RRID:MMRRC_042965-MU
Other Names:
R5393 (G1), C57BL/6J-MtgxR5393Btlr
Major Collection:

Strain Information

Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: Ick, 2210420N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Drd5
Name: dopamine receptor D5
Synonyms: Gpcr1, Drd1b, DRD1b, D5R, Drd-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13492
HGNC: HGNC:3026
Homologene: 20216
Pdlim5
Name: PDZ and LIM domain 5
Synonyms: Enh3, Enh2, Enh, 1110001A05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56376
Homologene: 21289
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Nudcd3
Name: NudC domain containing 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 209586
Homologene: 9097
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, GRAM domain, HBLP1, AD3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Ep300
Name: E1A binding protein p300
Synonyms: KAT3B, p300
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Cpsf6
Name: cleavage and polyadenylation specific factor 6
Synonyms: CFIM68, 4733401N12Rik, HPBRII-7, HPBRII-4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432508
Homologene: 134126
Lrmda
Name: leucine rich melanocyte differentiation associated
Synonyms: Oca7, 1700112E06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76633
Homologene: 49975
Adnp
Name: activity-dependent neuroprotective protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11538
Homologene: 7617
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: XCE, DINE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, p3, Pmscl2, PM-Scl, p4, RRP6, p2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Six3
Name: sine oculis-related homeobox 3
Synonyms: E130112M24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20473
Homologene: 3947
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberous sclerosis 2, tuberin, Nafld
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Marco
Name: macrophage receptor with collagenous structure
Synonyms: Scara2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17167
HGNC: HGNC:6895
Homologene: 4928
Klhl14
Name: kelch-like 14
Synonyms: 6330403N15Rik, printor
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225266
Homologene: 28121
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Miox
Name: myo-inositol oxygenase
Synonyms: Aldrl6, RSOR, C85427, 0610009I10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56727
Homologene: 9732
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: nha-oc, NHA2, C80638, NHE10, Nhedc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97086
Homologene: 45381
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241919
Homologene: 76320
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
C1galt1
Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
Synonyms: T-synthase, 2210410E06Rik, core 1 beta3-Gal-T
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94192
Homologene: 10599
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: Atp6n1a, V-ATPase a1, Atp6n1, Vpp1, Vpp-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Meak7
Name: MTOR associated protein, eak-7 homolog
Synonyms: 4632415K11Rik, Tldc1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74347
Homologene: 32494
Srsf9
Name: serine and arginine-rich splicing factor 9
Synonyms: 2610029M16Rik, SRp30c, Sfrs9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108014
Homologene: 20819
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Ctla2b
Name: cytotoxic T lymphocyte-associated protein 2 beta
Synonyms: Ctla-2b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13025
VEGA: 13
Homologene: 130627
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: 2610209L14Rik, Snf2l2, brm
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Tmem120a
Name: transmembrane protein 120A
Synonyms: 2010310D06Rik, Tmpit
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215210
Homologene: 12907
Irf9
Name: interferon regulatory factor 9
Synonyms: Irf-9, Isgf3g, p48
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16391
HGNC: HGNC:6131
Homologene: 4436
Hdac10
Name: histone deacetylase 10
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170787
Homologene: 23749
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: Catsperg, A230107C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320225
Homologene: 10915
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Or2ak6
Name: olfactory receptor family 2 subfamily AK member 6
Synonyms: MOR285-2, Olfr319, GA_x6K02T2NKPP-708319-707399
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258493
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Or2t46
Name: olfactory receptor family 2 subfamily T member 46
Synonyms: MOR275-11_p, MOR275-5, Olfr325, GA_x6K02T2NKPP-844642-843680
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258261
Homologene: 133015
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Septin14
Name: septin 14
Synonyms: 1700016K13Rik, Sept14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74222
Homologene: 87501
Trim3
Name: tripartite motif-containing 3
Synonyms: Rnf22, BERP1, HAC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55992
Homologene: 21290
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70081
Homologene: 133253
Acyp2
Name: acylphosphatase 2, muscle type
Synonyms: 2310004B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75572
HGNC: HGNC:180
Homologene: 41776
Fam89b
Name: family with sequence similarity 89, member B
Synonyms: Mtvr2, Fam89b, 1110021A21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17826
Homologene: 18749
Kcnk18
Name: potassium channel, subfamily K, member 18
Synonyms: Tresk-2, LOC332396, Tresk
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 332396
VEGA: 19
Homologene: 133808
Lce1i
Name: late cornified envelope 1I
Synonyms: 2310069N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76585
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: coronin 4, 9030208C03Rik, IR10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
Efcab8
Name: EF-hand calcium binding domain 8
Synonyms: EG329541
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100504221
Saa3
Name: serum amyloid A 3
Synonyms: Saa-3, l7R3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20210
Homologene: 137239
Adi1
Name: acireductone dioxygenase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104923
Homologene: 75081
Pcdhga5
Name: protocadherin gamma subfamily A, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93713
HGNC: HGNC:8703
Homologene: 69263
Zfp593os
Name: Zfp593 opposite strand
Synonyms: E130218I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77490
Ighv2-5
Name: immunoglobulin heavy variable 2-5
Synonyms: Gm16593
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 638605
Krtap6-6
Name: keratin associated protein 6-6
Synonyms: 1110025L11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68637
Gm15455
Name: predicted gene 15455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433287
Eloc
Name: elongin C
Synonyms: Tceb1, 2610301I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67923
Homologene: 38083
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 16,647,968 bp
  • G to A, chromosome 1 at 33,836,846 bp
  • A to T, chromosome 1 at 39,426,088 bp
  • A to T, chromosome 1 at 87,152,876 bp
  • A to C, chromosome 1 at 120,485,854 bp
  • A to G, chromosome 1 at 128,231,347 bp
  • A to T, chromosome 2 at 25,408,670 bp
  • C to T, chromosome 2 at 120,702,906 bp
  • C to T, chromosome 2 at 146,345,455 bp
  • G to A, chromosome 2 at 153,780,983 bp
  • T to C, chromosome 2 at 168,182,949 bp
  • A to G, chromosome 3 at 31,257,770 bp
  • T to C, chromosome 3 at 87,810,700 bp
  • T to A, chromosome 3 at 88,696,606 bp
  • T to C, chromosome 3 at 92,777,735 bp
  • T to C, chromosome 3 at 102,841,047 bp
  • T to C, chromosome 3 at 135,336,356 bp
  • T to A, chromosome 3 at 142,259,186 bp
  • A to G, chromosome 4 at 46,542,255 bp
  • G to A, chromosome 4 at 134,245,304 bp
  • T to C, chromosome 4 at 148,559,607 bp
  • T to A, chromosome 5 at 38,320,905 bp
  • C to T, chromosome 5 at 115,332,662 bp
  • T to A, chromosome 5 at 129,683,586 bp
  • T to C, chromosome 5 at 135,736,250 bp
  • T to C, chromosome 6 at 7,864,143 bp
  • A to T, chromosome 6 at 119,239,054 bp
  • A to C, chromosome 6 at 119,440,433 bp
  • A to G, chromosome 6 at 137,380,224 bp
  • A to T, chromosome 6 at 146,376,155 bp
  • T to C, chromosome 7 at 29,185,499 bp
  • T to C, chromosome 7 at 46,712,661 bp
  • G to A, chromosome 7 at 105,619,428 bp
  • T to C, chromosome 8 at 119,772,418 bp
  • A to G, chromosome 9 at 78,160,715 bp
  • T to A, chromosome 10 at 41,464,582 bp
  • G to C, chromosome 10 at 117,362,016 bp
  • C to T, chromosome 10 at 118,859,848 bp
  • T to C, chromosome 11 at 6,113,274 bp
  • C to T, chromosome 11 at 30,506,354 bp
  • C to G, chromosome 11 at 58,580,999 bp
  • T to A, chromosome 11 at 58,702,500 bp
  • T to A, chromosome 11 at 69,500,857 bp
  • T to C, chromosome 11 at 101,038,807 bp
  • T to A, chromosome 11 at 110,244,295 bp
  • A to G, chromosome 12 at 28,675,275 bp
  • T to C, chromosome 12 at 113,685,882 bp
  • T to A, chromosome 13 at 60,896,132 bp
  • A to C, chromosome 14 at 22,027,306 bp
  • T to C, chromosome 14 at 55,606,457 bp
  • A to T, chromosome 15 at 47,633,703 bp
  • A to G, chromosome 15 at 81,631,618 bp
  • T to C, chromosome 15 at 89,126,684 bp
  • C to T, chromosome 15 at 89,336,247 bp
  • A to T, chromosome 16 at 89,063,765 bp
  • A to T, chromosome 17 at 21,880,492 bp
  • T to C, chromosome 17 at 24,600,396 bp
  • T to C, chromosome 17 at 85,623,842 bp
  • A to G, chromosome 18 at 10,458,312 bp
  • G to T, chromosome 18 at 21,651,994 bp
  • C to T, chromosome 18 at 37,696,667 bp
  • C to A, chromosome 18 at 70,517,428 bp
  • T to C, chromosome 19 at 5,728,705 bp
  • T to G, chromosome 19 at 6,071,033 bp
  • C to A, chromosome 19 at 26,640,429 bp
  • T to C, chromosome 19 at 40,585,567 bp
  • T to C, chromosome 19 at 59,219,839 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5393 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042965-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.