Strain Name:
C57BL/6J-MtgxR5402Btlr/Mmmh
Stock Number:
042973-MU
Citation ID:
RRID:MMRRC_042973-MU
Other Names:
R5402 (G1), C57BL/6J-MtgxR5402Btlr
Major Collection:

Strain Information

Hapln1
Name: hyaluronan and proteoglycan link protein 1
Synonyms: LP-1, link protein, CLP, Crtl1, cartilage linking protein 1, Crtl1l
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12950
VEGA: 13
HGNC: HGNC:2380
Homologene: 1420
Csf2
Name: colony stimulating factor 2 (granulocyte-macrophage)
Synonyms: Csfgm, Gm-CSf, MGI-IGM, GMCSF
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12981
HGNC: HGNC:2434
Homologene: 600
Crlf3
Name: cytokine receptor-like factor 3
Synonyms: Creme9, cytor4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54394
Homologene: 9327
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9430095K15Rik, 9030421L11Rik, 9130004I02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20116
Homologene: 133143
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: D16Ium21, D16Ium21e, TPRD, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Estm14, Tle4l, C230057C06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21885
Homologene: 21058
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: 9330175N20Rik, RPC155, RPC1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Hus1
Name: HUS1 checkpoint clamp component
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15574
HGNC: HGNC:5309
Homologene: 37932
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Bcar1
Name: breast cancer anti-estrogen resistance 1
Synonyms: Crkas, Cas, p130Cas
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12927
HGNC: HGNC:971
Homologene: 7674
Fbxo9
Name: f-box protein 9
Synonyms: 9030401P18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71538
Homologene: 8217
Nxph4
Name: neurexophilin 4
Synonyms: 1110036M10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104080
HGNC: HGNC:8078
Homologene: 11020
Car9
Name: carbonic anhydrase 9
Synonyms: CAIX, MN/CA9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Il31ra
Name: interleukin 31 receptor A
Synonyms: GPL, GLM-R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, b2b414Clo, Dnchc2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, m152Asp, m407Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: 1110053F04Rik, Smsr, 1700010P07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67630
Homologene: 41670
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Cwf19l1
Name: CWF19 like cell cycle control factor 1
Synonyms: 2610528C06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72502
VEGA: 19
Homologene: 41244
Lbr
Name: lamin B receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98386
HGNC: HGNC:6518
Homologene: 2455
Chst9
Name: carbohydrate sulfotransferase 9
Synonyms: GalNAc4ST-2, 5430438D01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71367
Homologene: 12861
Hibadh
Name: 3-hydroxyisobutyrate dehydrogenase
Synonyms: 6430402H10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58875
HGNC: HGNC:4907
Homologene: 15088
Ccr7
Name: C-C motif chemokine receptor 7
Synonyms: Cmkbr7, Ebi1h, EBI1, CD197
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12775
HGNC: HGNC:1608
Homologene: 1387
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75288
Homologene: 45939
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Zfp1001
Name: zinc finger protein 1001
Synonyms: Gm10130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102633750
VEGA: 2
Slc13a4
Name: solute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms: 9630060C05Rik, SUT-1, SUT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243755
Homologene: 69125
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, aln, line 158, Thm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: Arhgap13, 4930572H05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Cgnl1
Name: cingulin-like 1
Synonyms: Jacop, 4933421H10Rik, 9930020M10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68178
Homologene: 41901
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: A730037L19Rik, D930040M24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320858
Homologene: 114383
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Gpi-ps
Name: glucose-6-phosphate isomerase, pseudogene
Synonyms: LOC233995, Gm1840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 669429
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 403088
Homologene: 74374
Scgb1b20
Name: secretoglobin, family 1B, member 20
Synonyms: Gm7147, Abpa20, Gm5895
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545948
Homologene: 114479
Pramel27
Name: PRAME like 27
Synonyms: Gm13103
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194225
Homologene: 129883
Ehbp1l1
Name: EH domain binding protein 1-like 1
Synonyms: G430002G23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 114601
VEGA: 19
Homologene: 136059
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: Hgfl, D9H3F15S2, DNF15S2h, D3F15S2h
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15235
Homologene: 7360
Or4s2b
Name: olfactory receptor family 4 subfamily S member 2B
Synonyms: MOR226-1, GA_x6K02T2Q125-50154044-50154826, GA_x6K02T2Q125-50158288-50158818, Olfr1193, Olfr1194-ps1, MOR230-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329460
Homologene: 27297
Pidd1
Name: p53 induced death domain protein 1
Synonyms: Pidd, Lrdd, 1200011D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57913
Homologene: 11220
Or2t1
Name: olfactory receptor family 2 subfamily T member 1
Synonyms: MTPCR53, MOR274-1, GA_x6K02T2PLTE-6714644-6715597, Olfr31
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18330
HGNC: HGNC:8277
Homologene: 74028
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PSS-1, PtdSer Synthase-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Coq9
Name: coenzyme Q9
Synonyms: 2310005O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67914
Homologene: 6477
Gmeb2
Name: glucocorticoid modulatory element binding protein 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229004
HGNC: HGNC:4371
Homologene: 8228
Col26a1
Name: collagen, type XXVI, alpha 1
Synonyms: Emu2, Collagen XXVI, 9430032K24Rik, Emid2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140709
Homologene: 136636
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Plat
Name: plasminogen activator, tissue
Synonyms: t-PA, tPA, D8Ertd2e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Etfa
Name: electron transferring flavoprotein, alpha polypeptide
Synonyms: D9Ertd394e, 2010200I21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110842
HGNC: HGNC:3481
Homologene: 100
Slc25a23
Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
Synonyms: SCaMC-3, 2310067G05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66972
Homologene: 11467
Nova2
Name: NOVA alternative splicing regulator 2
Synonyms: LOC384569
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384569
HGNC: HGNC:7887
Homologene: 134398
5031425E22Rik
Name: RIKEN cDNA 5031425E22 gene
Synonyms: BC050254
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269630
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24056
Homologene: 23450
Commd8
Name: COMM domain containing 8
Synonyms: IMAGE:1958590, D5Buc26e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27784
Homologene: 9873
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: Nalp1c, OTTMUSG00000006090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Pcdhga3
Name: protocadherin gamma subfamily A, 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93711
HGNC: HGNC:8701
Homologene: 75100
A330093E20Rik
Name: RIKEN cDNA A330093E20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107003
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 181,819,961 bp
  • G to A, chromosome 2 at 53,128,782 bp
  • T to C, chromosome 2 at 59,870,478 bp
  • A to C, chromosome 2 at 62,046,638 bp
  • C to T, chromosome 2 at 66,239,562 bp
  • T to A, chromosome 2 at 88,678,148 bp
  • A to G, chromosome 2 at 150,362,966 bp
  • A to T, chromosome 2 at 181,255,957 bp
  • A to G, chromosome 3 at 79,480,943 bp
  • A to G, chromosome 4 at 43,510,213 bp
  • T to C, chromosome 4 at 72,169,051 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • G to A, chromosome 4 at 143,851,655 bp
  • A to G, chromosome 5 at 23,433,071 bp
  • A to G, chromosome 5 at 72,159,827 bp
  • G to A, chromosome 5 at 136,744,209 bp
  • G to A, chromosome 6 at 22,143,952 bp
  • A to T, chromosome 6 at 35,301,782 bp
  • A to G, chromosome 6 at 42,591,926 bp
  • A to T, chromosome 6 at 52,546,980 bp
  • C to A, chromosome 7 at 18,958,446 bp
  • A to G, chromosome 7 at 33,373,231 bp
  • C to A, chromosome 7 at 141,438,594 bp
  • C to T, chromosome 8 at 5,639,761 bp
  • T to G, chromosome 8 at 22,772,722 bp
  • T to A, chromosome 8 at 94,851,825 bp
  • T to C, chromosome 8 at 111,714,330 bp
  • A to T, chromosome 9 at 7,114,949 bp
  • T to C, chromosome 9 at 55,454,739 bp
  • A to G, chromosome 9 at 71,629,321 bp
  • A to G, chromosome 9 at 78,087,620 bp
  • T to C, chromosome 9 at 108,084,209 bp
  • T to A, chromosome 10 at 76,483,314 bp
  • T to C, chromosome 10 at 121,785,760 bp
  • T to G, chromosome 10 at 126,008,740 bp
  • A to T, chromosome 10 at 127,526,264 bp
  • C to T, chromosome 11 at 9,010,240 bp
  • AC to ACC, chromosome 11 at 49,651,034 bp
  • A to T, chromosome 11 at 54,247,663 bp
  • T to C, chromosome 11 at 71,242,667 bp
  • T to A, chromosome 11 at 80,064,382 bp
  • A to G, chromosome 11 at 99,145,734 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • C to T, chromosome 12 at 57,737,031 bp
  • T to A, chromosome 12 at 76,059,439 bp
  • A to G, chromosome 13 at 66,933,599 bp
  • A to T, chromosome 13 at 81,459,715 bp
  • A to G, chromosome 13 at 89,605,411 bp
  • T to C, chromosome 13 at 112,524,135 bp
  • T to C, chromosome 14 at 14,328,878 bp
  • A to G, chromosome 14 at 21,775,168 bp
  • T to C, chromosome 14 at 24,454,941 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • A to T, chromosome 14 at 49,318,874 bp
  • T to A, chromosome 15 at 66,739,168 bp
  • C to T, chromosome 15 at 82,619,086 bp
  • T to G, chromosome 16 at 94,462,630 bp
  • T to C, chromosome 17 at 57,053,336 bp
  • T to C, chromosome 17 at 68,455,774 bp
  • A to G, chromosome 18 at 10,537,169 bp
  • A to T, chromosome 18 at 15,452,815 bp
  • G to A, chromosome 18 at 37,675,694 bp
  • A to C, chromosome 18 at 45,685,547 bp
  • T to A, chromosome 19 at 5,716,320 bp
  • C to T, chromosome 19 at 44,133,085 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5402 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042973-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.