Strain Name:
C57BL/6J-MtgxR5411Btlr/Mmmh
Stock Number:
042980-MU
Citation ID:
RRID:MMRRC_042980-MU
Other Names:
R5411 (G1), C57BL/6J-MtgxR5411Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109267
Homologene: 34137
Luzp1
Name: leucine zipper protein 1
Synonyms: Luzp, 2700072H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269593
Homologene: 11545
Sfpq
Name: splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
Synonyms: D4Ertd314e, 9030402K04Rik, 2810416M14Rik, 5730453G22Rik, 1110004P21Rik, REP1, PSF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71514
Homologene: 3714
Dhx9
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98732
Homologene: 40842
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Snx5
Name: sorting nexin 5
Synonyms: 1810032P22Rik, 0910001N05Rik, D2Ertd52e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69178
Homologene: 40944
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Nup133
Name: nucleoporin 133
Synonyms: 4832420O05Rik, mermaid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234865
Homologene: 32402
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269470
Homologene: 4937
Eya3
Name: EYA transcriptional coactivator and phosphatase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14050
HGNC: HGNC:3521
Homologene: 1508
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Eif3d
Name: eukaryotic translation initiation factor 3, subunit D
Synonyms: mouse translation initiation factor eIF3 p66, eIF3p66, 66/67kDa, Eif3s7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 55944
VEGA: 15
HGNC: HGNC:3278
Homologene: 2782
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77739
Homologene: 64642
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387314
Homologene: 65299
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142980
Homologene: 20696
Tmc2
Name: transmembrane channel-like gene family 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192140
Homologene: 25877
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: ADAR1, mZaADAR, Adar1p150, Adar1p110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Adgrf4
Name: adhesion G protein-coupled receptor F4
Synonyms: 4632435A09Rik, Gpr115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78249
Homologene: 51953
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Mep1b
Name: meprin 1 beta
Synonyms: Mep-1b, meprin beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Olfr1413
Name: olfactory receptor 1413
Synonyms: GA_x6K02T2R7CC-81180849-81179878, MOR208-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259039
Homologene: 128165
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 373864
Homologene: 69400
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207618
Homologene: 52304
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Il17ra
Name: interleukin 17 receptor A
Synonyms: VDw217, Il17r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207227
Homologene: 18173
Ttc19
Name: tetratricopeptide repeat domain 19
Synonyms: 2010204O13Rik, 2810460C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72795
Homologene: 9831
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2210420P05Rik, 2600014C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70297
Homologene: 45639
Tgm6
Name: transglutaminase 6
Synonyms: TGM3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241636
Homologene: 27970
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Ces3b
Name: carboxylesterase 3B
Synonyms: ES31L, Gm4738
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13909
HGNC: HGNC:1865
Homologene: 84407
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041581
Homologene: 26419
Brsk2
Name: BR serine/threonine kinase 2
Synonyms: SAD-A, 4833424K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75770
Homologene: 123829
Pramel31
Name: PRAME like 31
Synonyms: Gm13119
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433779
Homologene: 83161
Olfr1178
Name: olfactory receptor 1178
Synonyms: GA_x6K02T2Q125-49870417-49871388, MOR225-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258203
Homologene: 73979
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74121
Homologene: 75083
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, A330035H04Rik, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216739
Homologene: 100939
Esp8
Name: exocrine gland secreted peptide 8
Synonyms: Gm17495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126778
VEGA: 17
Homologene: 136357
Parp12
Name: poly (ADP-ribose) polymerase family, member 12
Synonyms: Zc3hdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243771
Homologene: 11236
Mrps22
Name: mitochondrial ribosomal protein S22
Synonyms: Rpms22, 3100002P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64655
Homologene: 57030
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: Acat, 6330585C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Shisa7
Name: shisa family member 7
Synonyms: D430041B17Rik, CKAMP59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232813
Homologene: 122129
Chpt1
Name: choline phosphotransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212862
Homologene: 69297
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320452
Homologene: 27943
Olfr1231
Name: olfactory receptor 1231
Synonyms: GA_x6K02T2Q125-50748233-50747292, MOR235-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258446
Homologene: 27168
Phf11a
Name: PHD finger protein 11A
Synonyms: 4933417L10Rik, Phf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219131
Homologene: 87807
Mfsd13b
Name: major facilitator superfamily domain containing 13B
Synonyms: 4933427G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74466
Homologene: 62261
Efcab8
Name: EF-hand calcium binding domain 8
Synonyms: EG329541
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100504221
Sco1
Name: SCO1 cytochrome c oxidase assembly protein
Synonyms: 2610001C07Rik, D11Bwg1310e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52892
Homologene: 3374
Atp6v1g3
Name: ATPase, H+ transporting, lysosomal V1 subunit G3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 338375
Homologene: 13630
Olfr192
Name: olfactory receptor 192
Synonyms: GA_x54KRFPKG5P-55327126-55326203, MOR183-11_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 404309
Homologene: 131129
Arhgap20os
Name: Rho GTPase activating protein 20, opposite strand
Synonyms: 9230115E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 408028
Kcnk13
Name: potassium channel, subfamily K, member 13
Synonyms: LOC381712, LOC380778, F730021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217826
HGNC: HGNC:6275
Homologene: 69351
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 92,573,824 bp
  • G to T, chromosome 1 at 136,105,811 bp
  • A to T, chromosome 1 at 138,287,889 bp
  • G to T, chromosome 1 at 153,481,223 bp
  • A to G, chromosome 1 at 185,277,145 bp
  • A to C, chromosome 2 at 52,295,372 bp
  • A to G, chromosome 2 at 88,391,261 bp
  • A to C, chromosome 2 at 89,303,576 bp
  • A to T, chromosome 2 at 127,854,901 bp
  • G to A, chromosome 2 at 130,145,196 bp
  • A to G, chromosome 2 at 130,240,115 bp
  • A to T, chromosome 2 at 130,933,452 bp
  • T to C, chromosome 2 at 144,257,157 bp
  • A to G, chromosome 2 at 153,783,756 bp
  • T to A, chromosome 2 at 164,902,245 bp
  • T to A, chromosome 3 at 89,739,212 bp
  • C to A, chromosome 3 at 100,142,984 bp
  • CTTCAGCTTTCA to CTTCA, chromosome 4 at 58,956,745 bp
  • T to C, chromosome 4 at 63,224,665 bp
  • G to A, chromosome 4 at 86,388,413 bp
  • T to A, chromosome 4 at 127,021,723 bp
  • A to T, chromosome 4 at 132,689,779 bp
  • C to A, chromosome 4 at 136,543,342 bp
  • T to A, chromosome 4 at 144,361,637 bp
  • A to T, chromosome 5 at 6,770,071 bp
  • A to T, chromosome 5 at 14,678,080 bp
  • T to A, chromosome 5 at 96,645,160 bp
  • A to G, chromosome 5 at 114,458,973 bp
  • T to A, chromosome 5 at 135,963,400 bp
  • C to T, chromosome 5 at 137,290,064 bp
  • T to A, chromosome 5 at 137,290,430 bp
  • A to G, chromosome 6 at 39,090,208 bp
  • A to G, chromosome 6 at 120,481,442 bp
  • C to T, chromosome 6 at 142,448,421 bp
  • A to T, chromosome 6 at 148,443,899 bp
  • G to A, chromosome 7 at 4,829,976 bp
  • A to T, chromosome 7 at 100,293,815 bp
  • A to T, chromosome 7 at 121,000,123 bp
  • T to C, chromosome 7 at 142,000,857 bp
  • T to A, chromosome 8 at 15,910,471 bp
  • A to T, chromosome 8 at 45,396,955 bp
  • T to C, chromosome 8 at 105,088,632 bp
  • T to C, chromosome 8 at 123,927,206 bp
  • T to A, chromosome 9 at 44,848,485 bp
  • C to T, chromosome 9 at 51,840,566 bp
  • C to A, chromosome 9 at 53,582,646 bp
  • C to T, chromosome 9 at 98,598,122 bp
  • G to A, chromosome 10 at 12,649,185 bp
  • A to G, chromosome 10 at 34,394,557 bp
  • T to C, chromosome 10 at 58,270,969 bp
  • A to T, chromosome 10 at 88,477,107 bp
  • A to G, chromosome 11 at 54,338,519 bp
  • G to T, chromosome 11 at 55,252,226 bp
  • A to G, chromosome 11 at 62,284,151 bp
  • A to G, chromosome 11 at 67,063,958 bp
  • G to T, chromosome 11 at 103,882,811 bp
  • G to A, chromosome 12 at 51,888,243 bp
  • A to G, chromosome 12 at 100,061,251 bp
  • C to T, chromosome 13 at 100,245,746 bp
  • T to C, chromosome 14 at 59,294,938 bp
  • A to T, chromosome 15 at 77,959,687 bp
  • G to A, chromosome 16 at 37,129,851 bp
  • T to A, chromosome 16 at 59,098,704 bp
  • C to T, chromosome 17 at 40,530,018 bp
  • A to C, chromosome 17 at 42,667,213 bp
  • T to A, chromosome 18 at 21,086,249 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5411 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042980-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.