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Strain Name:
C57BL/6J-MtgxR5412Btlr/Mmmh
Stock Number:
042981-MU
Citation ID:
RRID:MMRRC_042981-MU
Other Names:
R5412 (G1), C57BL/6J-MtgxR5412Btlr
Major Collection:

Strain Information

Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Cdk13
Name: cyclin dependent kinase 13
Synonyms: 2310015O17Rik, Cdc2l5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Ndc80
Name: NDC80 kinetochore complex component
Synonyms: HEC1, 2610020P18Rik, Kntc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67052
VEGA: 17
Homologene: 38141
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: Osa1, 1110030E03Rik, Smarcf1, BAF250a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, Ars2, 2810019G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Zfp26
Name: zinc finger protein 26
Synonyms: mkr-3, Zfp-26, 5033428C05Rik, Zfp70, KRAB15, Zfp81-rs1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22688
Homologene: 52318
Pon1
Name: paraoxonase 1
Synonyms: Pon
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18979
HGNC: HGNC:9204
Homologene: 68058
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Prdx6
Name: peroxiredoxin 6
Synonyms: acidic calcium-independent phospholipase A2, aiPLA2, GPx, Brp-12, Ltw4, Lvtw-4, Ltw-4, 1-Cys Prx, CP-3, Aop2, 1-cysPrx, 9430088D19Rik, NSGP, CC26
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11758
Homologene: 3606
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: Npac, 2810419J22Rik, 3930401K13Rik, NDF
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74022
VEGA: 16
Homologene: 12525
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
Synonyms: D830027H13Rik, Hnrpl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15388
HGNC: HGNC:5045
Homologene: 1174
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, 3830418C19Rik, Smc6l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
C3
Name: complement component 3
Synonyms: complement factor 3, acylation stimulating protein, Plp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Katnal2
Name: katanin p60 subunit A-like 2
Synonyms: 4933439B08Rik, 3110023G01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71206
Homologene: 41725
Tm2d1
Name: TM2 domain containing 1
Synonyms: 2310026L18Rik, Bbp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 94043
Homologene: 12928
Ndufs1
Name: NADH:ubiquinone oxidoreductase core subunit S1
Synonyms: 9930026A05Rik, 5830412M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227197
HGNC: HGNC:7707
Homologene: 3670
Otop1
Name: otopetrin 1
Synonyms: A530025J20Rik, tlt
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21906
Homologene: 35244
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56406
Homologene: 137337
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, flamingo, EGFL2, Adgrc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70417
Homologene: 23771
Ly6g2
Name: lymphocyte antigen 6 family member G2
Synonyms: BC025446
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223631
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd370e, D8Ertd377e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57247
Homologene: 10731
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70729
Homologene: 135990
Grk4
Name: G protein-coupled receptor kinase 4
Synonyms: A830025H08Rik, Gprk2l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14772
HGNC: HGNC:4543
Homologene: 23158
Vmn1r216
Name: vomeronasal 1 receptor 216
Synonyms: V1ri10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171279
Homologene: 110880
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: LOC382543, 4932411E22Rik, nmf9, mWAKE
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 382543
Homologene: 34996
Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms: P450RAI, P450RA, retinoic acid hydrolase, RAH, Cyp26
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13082
VEGA: 19
HGNC: HGNC:2603
Homologene: 37349
Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms: 1600019A21Rik, Spi10, R86, ovalbumin, SPI-CI
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20706
HGNC: HGNC:8955
Homologene: 137240
Krt16
Name: keratin 16
Synonyms: K16, Krt1-16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Serpinb8
Name: serine (or cysteine) peptidase inhibitor, clade B, member 8
Synonyms: Spi8, NK10, ovalbumin, CAP-2, CAP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20725
HGNC: HGNC:8952
Homologene: 74445
Zfp683
Name: zinc finger protein 683
Synonyms: Hobit
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100503878
Zpld1
Name: zona pellucida like domain containing 1
Synonyms: 9430016A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239852
Homologene: 18401
Stpg1
Name: sperm tail PG rich repeat containing 1
Synonyms: 4930403G18Rik, 4930555I21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78806
Homologene: 12705
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269209
Homologene: 49432
Zfp330
Name: zinc finger protein 330
Synonyms: nucleolar autoantigen 36, NOA 36, Noa36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 30932
Homologene: 8714
Nkx2-6
Name: NK2 homeobox 6
Synonyms: Tix, Nkx2.6, tinman, Nkx-2.6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18092
Homologene: 22604
Ccpg1
Name: cell cycle progression 1
Synonyms: 1700030B06Rik, 1810073J13Rik, D9Ertd392e, 9430028F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72278
Homologene: 3487
Egfl7
Name: EGF-like domain 7
Synonyms: Zneu1, VE-statin, vascular endothelial-statin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353156
Homologene: 9427
Gpc2
Name: glypican 2 cerebroglycan
Synonyms: 2410016G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71951
HGNC: HGNC:4450
Homologene: 17657
4932442E05Rik
Name: RIKEN cDNA 4932442E05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Gm11127
Name: predicted gene 11127
Synonyms: Gm11127
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100529082
Homologene: 133121
Map10
Name: microtubule-associated protein 10
Synonyms: 4933403G14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74393
Homologene: 10416
Or6a2
Name: olfactory receptor family 6 subfamily A member 2
Synonyms: I54, I7, Olfr41, GA_x6K02T2PBJ9-9381439-9380456, MOR103-15, Olfr2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18317
Homologene: 2743
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
Selenon
Name: selenoprotein N
Synonyms: 1110019I12Rik, Sepn1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74777
Homologene: 10723
Hsd3b2
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15493
Homologene: 133013
Stra8
Name: stimulated by retinoic acid gene 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20899
Homologene: 49197
Tmem150b
Name: transmembrane protein 150B
Synonyms: Tmem224
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330460
Homologene: 19603
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Pcdha5
Name: protocadherin alpha 5
Synonyms: Cnr6, Crnr6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12941
HGNC: HGNC:8671
Homologene: 49565
Rpl35a-ps7
Name: ribosomal protein L35A, pseudogene 7
Synonyms: Gm3167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100041154
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,635,344 bp
  • T to C, chromosome 1 at 63,166,349 bp
  • G to T, chromosome 1 at 74,605,456 bp
  • G to A, chromosome 1 at 107,605,886 bp
  • A to T, chromosome 1 at 161,244,290 bp
  • T to A, chromosome 1 at 170,349,399 bp
  • T to C, chromosome 2 at 26,590,933 bp
  • C to T, chromosome 2 at 31,346,617 bp
  • T to C, chromosome 2 at 155,407,781 bp
  • A to T, chromosome 3 at 36,599,373 bp
  • A to G, chromosome 3 at 98,711,892 bp
  • G to T, chromosome 3 at 108,399,995 bp
  • C to T, chromosome 4 at 88,820,143 bp
  • G to A, chromosome 4 at 98,365,618 bp
  • T to C, chromosome 4 at 133,719,602 bp
  • C to A, chromosome 4 at 134,054,551 bp
  • T to C, chromosome 4 at 134,542,438 bp
  • T to A, chromosome 4 at 135,525,475 bp
  • C to T, chromosome 4 at 152,128,125 bp
  • A to T, chromosome 5 at 34,745,268 bp
  • A to G, chromosome 5 at 38,297,984 bp
  • T to A, chromosome 5 at 76,616,862 bp
  • A to T, chromosome 5 at 137,296,287 bp
  • T to C, chromosome 5 at 138,274,303 bp
  • A to G, chromosome 6 at 5,185,314 bp
  • G to A, chromosome 6 at 34,930,950 bp
  • A to T, chromosome 6 at 47,815,371 bp
  • G to A, chromosome 6 at 90,662,878 bp
  • A to C, chromosome 7 at 4,716,369 bp
  • A to G, chromosome 7 at 28,811,104 bp
  • A to G, chromosome 7 at 107,001,635 bp
  • T to C, chromosome 8 at 82,764,236 bp
  • A to T, chromosome 8 at 123,255,781 bp
  • A to T, chromosome 8 at 125,670,985 bp
  • T to C, chromosome 9 at 20,438,239 bp
  • T to A, chromosome 9 at 55,978,752 bp
  • A to T, chromosome 9 at 73,010,306 bp
  • C to A, chromosome 10 at 17,902,296 bp
  • T to A, chromosome 10 at 118,861,368 bp
  • C to T, chromosome 11 at 75,450,794 bp
  • T to A, chromosome 11 at 89,505,181 bp
  • T to A, chromosome 11 at 100,246,767 bp
  • A to G, chromosome 12 at 11,285,399 bp
  • G to A, chromosome 13 at 17,766,530 bp
  • A to G, chromosome 13 at 23,099,911 bp
  • A to G, chromosome 13 at 33,029,513 bp
  • T to C, chromosome 14 at 61,204,910 bp
  • G to T, chromosome 14 at 69,174,746 bp
  • G to A, chromosome 15 at 35,533,385 bp
  • A to T, chromosome 15 at 75,217,820 bp
  • C to A, chromosome 15 at 89,068,932 bp
  • A to G, chromosome 16 at 5,036,433 bp
  • T to A, chromosome 16 at 55,232,283 bp
  • G to T, chromosome 16 at 89,884,865 bp
  • C to T, chromosome 17 at 36,056,044 bp
  • T to C, chromosome 17 at 57,220,187 bp
  • C to A, chromosome 17 at 71,514,231 bp
  • T to A, chromosome 17 at 78,954,711 bp
  • C to A, chromosome 18 at 36,962,457 bp
  • A to T, chromosome 18 at 57,191,147 bp
  • A to T, chromosome 18 at 77,002,435 bp
  • G to T, chromosome 19 at 37,701,182 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5412 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042981-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.