Strain Name:
C57BL/6J-MtgxR5430Btlr/Mmmh
Stock Number:
042996-MU
Citation ID:
RRID:MMRRC_042996-MU
Other Names:
R5430 (G1), C57BL/6J-MtgxR5430Btlr
Major Collection:

Gene Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Lpk, M100856, Col2, Rgsc856, Col2a, Col2a-1, M100413, Rgsc413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: Acra3, Acra-3, A730007P14Rik, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, alpha 3, (a)3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224273
Homologene: 28544
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20981
Homologene: 9617
Papola
Name: poly (A) polymerase alpha
Synonyms: Plap, PapIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18789
Homologene: 23389
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: SAP25, LRN, 2810008P14Rik, LRRN4, 2900069C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269470
Homologene: 4937
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: Ira1, 8030499H02Rik, A630076E03Rik, C230089I12Rik, TBLR1, DC42, C21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 81004
Homologene: 69382
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17279
Homologene: 32111
Arhgef1
Name: Rho guanine nucleotide exchange factor (GEF) 1
Synonyms: Lsc, Lbcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Eipr1
Name: EARP complex and GARP complex interacting protein 1
Synonyms: Tssc1, D12Ertd604e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 380752
VEGA: 12
Homologene: 2481
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68421
Homologene: 10156
Atf7ip2
Name: activating transcription factor 7 interacting protein 2
Synonyms: PSM2, 4930558K11Rik, Get-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 75329
Homologene: 23509
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319670
VEGA: 12
Homologene: 26807
Jag1
Name: jagged 1
Synonyms: Ozz, Serrate-1, Gsfabe2, Htu, ABE2, Headturner
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Oca2
Name: oculocutaneous albinism II
Synonyms: D7H15S12, p, D7H15S12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18431
HGNC: HGNC:8101
Homologene: 37281
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: A2mr, b2b1554Clo, CD91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Olfr720
Name: olfactory receptor 720
Synonyms: MOR274-2, GA_x6K02T2PLTE-6544896-6543946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258387
Homologene: 74036
Ptprh
Name: protein tyrosine phosphatase, receptor type, H
Synonyms: SAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: ENSMUSG00000073143, A630082K20Rik, Kdm7a, Jhdm1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 338523
Homologene: 25281
Vsig8
Name: V-set and immunoglobulin domain containing 8
Synonyms: EG240916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240916
Homologene: 18616
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: sema III, Semad, collapsin-1, SemD, semaphorin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20346
Homologene: 31358
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, Rab6ip1, 1500012B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 19347
Homologene: 14584
Olfr1258
Name: olfactory receptor 1258
Synonyms: MOR232-3, GA_x6K02T2Q125-51361752-51362687
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258980
Homologene: 82299
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: 1110062M20Rik, ORP-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99031
Homologene: 101447
Gm16432
Name: predicted gene 16432
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 54380
Homologene: 8558
Ankrd34a
Name: ankyrin repeat domain 34A
Synonyms: Ankrd34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 545554
Homologene: 82882
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: Them1, BFIT1, 2010309H15Rik, Thea, 1110020M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329910
Homologene: 11977
Zfp52
Name: zinc finger protein 52
Synonyms: zfec29, Zfp76, KRAB11, Zfp-52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22710
VEGA: 17
Homologene: 77326
Stmn4
Name: stathmin-like 4
Synonyms: RB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56471
Homologene: 10496
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 140810
Homologene: 62795
Gnat2
Name: guanine nucleotide binding protein, alpha transducing 2
Synonyms: Gt-2, Gnat-2, Tcalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14686
HGNC: HGNC:4394
Homologene: 21092
Mettl24
Name: methyltransferase like 24
Synonyms: 9030224M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327747
Homologene: 65335
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100042810
Homologene: 113703
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Ntpcr
Name: nucleoside-triphosphatase, cancer-related
Synonyms: 2310079N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66566
Homologene: 11989
Zfp354c
Name: zinc finger protein 354C
Synonyms: Kid3, AJ18, 5330421P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 30944
Homologene: 56606
Magohb
Name: mago homolog B, exon junction complex core component
Synonyms: 2010012C16Rik, Magoh-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66441
Homologene: 56794
Brsk1
Name: BR serine/threonine kinase 1
Synonyms: SAD-B, LOC381979
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381979
Homologene: 57169
Pex12
Name: peroxisomal biogenesis factor 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103737
HGNC: HGNC:8854
Homologene: 240
Cpm
Name: carboxypeptidase M
Synonyms: 5730456K23Rik, 1110060I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70574
HGNC: HGNC:2311
Homologene: 35367
Eid1
Name: EP300 interacting inhibitor of differentiation 1
Synonyms: EID-1, 2610002K20Rik, ORF12, Cri1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 58521
HGNC: HGNC:1191
Homologene: 49376
Gm11127
Name: predicted gene 11127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100529082
HGNC: HGNC:4963
Homologene: 133121
Slc38a8
Name: solute carrier family 38, member 8
Synonyms: LOC234788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234788
Homologene: 19028
Mylk2
Name: myosin, light polypeptide kinase 2, skeletal muscle
Synonyms: 9830004H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228785
Homologene: 13223
Vmn1r238
Name: vomeronasal 1 receptor, 238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 100312476
Homologene: 128342
Ppm1k
Name: protein phosphatase 1K (PP2C domain containing)
Synonyms: A930026L03Rik, PP2Cm, 2900063A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243382
Homologene: 36819
Gm11787
Name: predicted gene 11787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 666513
Mup4
Name: major urinary protein 4
Synonyms: Mup-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17843
Homologene: 74304
Olfr127
Name: olfactory receptor 127
Synonyms: GA_x6K02T2PSCP-2354126-2355093, MOR218-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258374
Homologene: 134080
Sfn
Name: stratifin
Synonyms: Ywhas, 14-3-3 sigma, Er, MME1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 55948
Homologene: 4475
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp, Lsh, Ity1, Ity, Bcg, ity, Nramp1, host resistance locus Bcg/Ity/Lsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18173
Homologene: 73884
Nppb
Name: natriuretic peptide type B
Synonyms: BNP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18158
HGNC: HGNC:7940
Homologene: 49182
1700001J11Rik
Name: RIKEN cDNA 1700001J11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 72224
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 24,692,980 bp
  • T to C, chromosome 1 at 72,626,617 bp
  • A to G, chromosome 1 at 74,380,172 bp
  • T to C, chromosome 1 at 172,559,629 bp
  • A to T, chromosome 1 at 178,111,254 bp
  • T to C, chromosome 2 at 76,586,138 bp
  • A to T, chromosome 2 at 89,929,913 bp
  • C to T, chromosome 2 at 120,777,565 bp
  • A to G, chromosome 2 at 125,673,630 bp
  • T to C, chromosome 2 at 137,101,706 bp
  • A to T, chromosome 2 at 152,917,548 bp
  • T to A, chromosome 3 at 22,192,082 bp
  • G to A, chromosome 3 at 96,597,521 bp
  • G to A, chromosome 3 at 100,157,327 bp
  • T to C, chromosome 3 at 108,098,400 bp
  • A to T, chromosome 4 at 3,512,786 bp
  • A to G, chromosome 4 at 44,309,033 bp
  • A to T, chromosome 4 at 59,960,044 bp
  • C to T, chromosome 4 at 106,760,130 bp
  • T to C, chromosome 4 at 133,601,627 bp
  • C to T, chromosome 4 at 147,986,381 bp
  • A to T, chromosome 5 at 13,565,763 bp
  • T to C, chromosome 5 at 137,638,533 bp
  • A to G, chromosome 6 at 39,149,342 bp
  • A to T, chromosome 6 at 57,524,886 bp
  • A to G, chromosome 6 at 131,289,418 bp
  • T to A, chromosome 7 at 4,551,047 bp
  • T to C, chromosome 7 at 4,710,436 bp
  • A to C, chromosome 7 at 8,483,334 bp
  • C to A, chromosome 7 at 24,912,307 bp
  • T to G, chromosome 7 at 44,390,913 bp
  • T to C, chromosome 7 at 56,295,460 bp
  • T to C, chromosome 7 at 109,934,240 bp
  • A to G, chromosome 8 at 119,494,220 bp
  • A to G, chromosome 8 at 125,730,060 bp
  • T to A, chromosome 9 at 40,052,291 bp
  • C to T, chromosome 9 at 55,012,908 bp
  • G to T, chromosome 10 at 40,737,784 bp
  • A to G, chromosome 10 at 117,676,081 bp
  • G to A, chromosome 10 at 127,541,061 bp
  • A to G, chromosome 11 at 50,815,195 bp
  • T to C, chromosome 11 at 83,297,746 bp
  • A to T, chromosome 12 at 28,863,016 bp
  • T to C, chromosome 12 at 98,794,158 bp
  • T to C, chromosome 12 at 105,809,584 bp
  • C to T, chromosome 14 at 14,175,692 bp
  • A to G, chromosome 14 at 66,358,014 bp
  • A to G, chromosome 15 at 97,995,022 bp
  • T to C, chromosome 16 at 10,204,674 bp
  • C to T, chromosome 16 at 20,523,731 bp
  • A to G, chromosome 16 at 59,524,926 bp
  • A to G, chromosome 17 at 21,555,067 bp
  • G to A, chromosome 17 at 24,444,970 bp
  • C to T, chromosome 17 at 36,056,075 bp
  • T to A, chromosome 17 at 37,904,413 bp
  • G to T, chromosome 18 at 3,122,521 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5430 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042996-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.