Strain Name:
C57BL/6J-MtgxR5438Btlr/Mmmh
Stock Number:
043003-MU
Citation ID:
RRID:MMRRC_043003-MU
Other Names:
R5438 (G1), C57BL/6J-MtgxR5438Btlr
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Zfa-ps
Name: zinc finger protein, autosomal, pseudogene
Synonyms: Zfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22639
Sncg
Name: synuclein, gamma
Synonyms: persyn, C79089
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20618
Homologene: 2322
Smad1
Name: SMAD family member 1
Synonyms: Madr1, Smad 1, Madh1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17125
HGNC: HGNC:6767
Homologene: 21196
Zc3h11a
Name: zinc finger CCCH type containing 11A
Synonyms: 1110003F06Rik, 5730454B08Rik, G630041M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70579
Homologene: 8888
Hvcn1
Name: hydrogen voltage-gated channel 1
Synonyms: 0610039P13Rik, mVSOP, BTS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74096
Homologene: 12535
Arpc2
Name: actin related protein 2/3 complex, subunit 2
Synonyms: 2210023N03Rik, p34-Arc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76709
HGNC: HGNC:705
Homologene: 4187
Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Synonyms: Nip3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12176
HGNC: HGNC:1084
Homologene: 2990
Zfp472
Name: zinc finger protein 472
Synonyms: Krim-1, Krim-1B, Krim-1A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224691
Homologene: 77422
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Gdap2
Name: ganglioside-induced differentiation-associated-protein 2
Synonyms: D3Ertd801e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14547
Homologene: 7728
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, PM-Scl, RRP6, p4, p3, p2, Pmscl2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Fam219a
Name: family with sequence similarity 219, member A
Synonyms: 2310028H24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71901
Homologene: 51830
Ptger2
Name: prostaglandin E receptor 2 (subtype EP2)
Synonyms: EP2, Ptgerep2, EP2 receptor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19217
HGNC: HGNC:9594
Homologene: 739
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Kcnn3
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms: small conductance calcium-activated potassium channel 3, SK3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140493
HGNC: HGNC:6292
Homologene: 20516
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: CFEX, Pat1, B930010B04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 171429
Homologene: 99903
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Otud7a
Name: OTU domain containing 7A
Synonyms: Cezanne 2 protein, Otud7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 170711
Homologene: 15642
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Pcdh18
Name: protocadherin 18
Synonyms: PCDH68L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73173
Homologene: 10389
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Elp4
Name: elongator acetyltransferase complex subunit 4
Synonyms: A330107A17Rik, Paxneb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77766
HGNC: HGNC:1171
Homologene: 32433
Cimip4
Name: ciliary microtubule inner protein 4
Synonyms: 1700061J05Rik, Tex33
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73376
VEGA: 15
Homologene: 18682
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: OTTMUSG00000015915, 5430413K10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433492
Homologene: 128535
Or5m8
Name: olfactory receptor family 5 subfamily M member 8
Synonyms: GA_x6K02T2Q125-47470765-47471775, MOR200-1, Olfr1031
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257916
Homologene: 73973
Slc24a5
Name: solute carrier family 24, member 5
Synonyms: NCX5, F630045L20Rik, NCKX5, Oca6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 317750
Homologene: 18400
Adamts17
Name: ADAM metallopeptidase with thrombospondin type 1 motif 17
Synonyms: AU023434
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233332
Homologene: 16373
Ift88
Name: intraflagellar transport 88
Synonyms: Tg737, polaris, Oak Ridge polycystic kidneys, orpk, IFT88, fxo, TgN737Rpw, Tg737Rpw, Ttc10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21821
Homologene: 4761
Slc35f2
Name: solute carrier family 35, member F2
Synonyms: 1500009K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72022
VEGA: 9
Homologene: 36363
Or52n5
Name: olfactory receptor family 52 subfamily N member 5
Synonyms: GA_x6K02T2PBJ9-7567376-7568329, MOR34-6, Olfr669
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259045
Homologene: 72057
B130046B21Rik
Name: RIKEN cDNA B130046B21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
VEGA: 15
WI1-1993I8.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 74,236,836 bp
  • C to T, chromosome 1 at 133,640,647 bp
  • T to A, chromosome 2 at 76,754,824 bp
  • T to C, chromosome 2 at 85,992,581 bp
  • A to G, chromosome 2 at 105,904,403 bp
  • A to G, chromosome 2 at 125,068,865 bp
  • T to A, chromosome 2 at 154,309,368 bp
  • A to T, chromosome 3 at 49,756,016 bp
  • T to A, chromosome 3 at 89,521,298 bp
  • A to T, chromosome 3 at 100,178,313 bp
  • A to G, chromosome 3 at 104,464,220 bp
  • A to G, chromosome 4 at 41,520,302 bp
  • T to A, chromosome 4 at 148,566,342 bp
  • A to G, chromosome 5 at 122,238,464 bp
  • G to A, chromosome 5 at 149,285,423 bp
  • A to G, chromosome 6 at 40,684,521 bp
  • C to T, chromosome 6 at 135,736,306 bp
  • A to G, chromosome 7 at 42,489,470 bp
  • A to G, chromosome 7 at 63,757,459 bp
  • C to A, chromosome 7 at 66,888,417 bp
  • G to A, chromosome 7 at 104,939,137 bp
  • T to C, chromosome 7 at 138,909,400 bp
  • C to T, chromosome 8 at 22,014,554 bp
  • A to T, chromosome 8 at 79,356,320 bp
  • T to A, chromosome 9 at 53,801,018 bp
  • A to T, chromosome 9 at 106,013,696 bp
  • A to T, chromosome 9 at 108,856,857 bp
  • T to C, chromosome 10 at 52,543,399 bp
  • G to T, chromosome 10 at 63,135,839 bp
  • T to A, chromosome 11 at 76,791,966 bp
  • T to A, chromosome 12 at 113,964,469 bp
  • A to T, chromosome 13 at 67,619,586 bp
  • G to T, chromosome 13 at 93,095,199 bp
  • C to T, chromosome 14 at 34,373,680 bp
  • A to T, chromosome 14 at 44,989,644 bp
  • T to C, chromosome 14 at 57,480,855 bp
  • T to C, chromosome 15 at 78,378,840 bp
  • A to G, chromosome 15 at 98,814,648 bp
  • A to G, chromosome 16 at 36,900,508 bp
  • T to A, chromosome 17 at 32,978,219 bp
  • T to A, chromosome 17 at 67,800,774 bp
  • A to G, chromosome 17 at 73,326,484 bp
  • T to A, chromosome 17 at 75,291,326 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5438 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043003-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.