Strain Name:
C57BL/6J-MtgxR5442Btlr/Mmmh
Stock Number:
043007-MU
Citation ID:
RRID:MMRRC_043007-MU
Other Names:
R5442 (G1), C57BL/6J-MtgxR5442Btlr
Major Collection:

Gene Information

Lmf1
Name: lipase maturation factor 1
Synonyms: Tmem112, 2400010G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 76483
Homologene: 23384
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 271639
Homologene: 10188
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 170750
Homologene: 6424
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, Alfy, 2610509D04Rik, Bchs, Ggtb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72145
Homologene: 22855
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 210711
Homologene: 11749
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, C130039F11Rik, nesprin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64009
VEGA: 10
Homologene: 52329
Rab3ip
Name: RAB3A interacting protein
Synonyms: SSX2 interacting protein, Rabin3, Gtpat12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216363
VEGA: 10
Homologene: 32340
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223435
VEGA: 15
Homologene: 20847
Tmem135
Name: transmembrane protein 135
Synonyms: 2810439K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72759
Homologene: 11295
Casc3
Name: cancer susceptibility candidate 3
Synonyms: Btz, Mln51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192160
Homologene: 7208
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: p600, A930005E13Rik, 1810009A16Rik, LOC381562, D930005K06Rik, Zubr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69116
Homologene: 10804
Phrf1
Name: PHD and ring finger domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101471
Homologene: 16377
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 2310016P22Rik, Epac1, 9330170P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223864
Homologene: 21231
Ltbr
Name: lymphotoxin B receptor
Synonyms: Ltar, LT beta-R, TNF-R-III, TNFRrp, TNFCR, TNFR2-RP, LTbetaR, Tnfbr, Tnfrsf3, LT-beta receptor, TNF receptor-related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56079
Homologene: 77850
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 637896
HGNC: null
Homologene: 115466
Pakap
Name: paralemmin A kinase anchor protein
Synonyms: Palm2Akap2, Gm20459, AF064781, Akap2, AKAP-KL, B230340M18Rik, Palm2, 53-H12, pEN70, Palm2-Akap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11641
HGNC: null
Homologene: null
Olfr898
Name: olfactory receptor 898
Synonyms: MOR170-3, GA_x6K02T2PVTD-32037624-32038565
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258871
VEGA: 9
HGNC: null
Homologene: 133654
Gm14085
Name: predicted gene 14085
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381417
Homologene: null
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330267
Homologene: 46582
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 64899
Homologene: 84844
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 319713
VEGA: 18
Homologene: 69175
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Fafl2, Dffry
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 107868
Homologene: 68408
Apol10a
Name: apolipoprotein L 10A
Synonyms: 9030421J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 245282
HGNC: null
Homologene: 129975
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: 4933424A20Rik, D2Ertd624e, 4932702F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74410
Homologene: 77534
Vmn1r70
Name: vomeronasal 1 receptor 70
Synonyms: V1rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 171262
HGNC: null
Homologene: 74361
Dyrk2
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101613
Homologene: 15881
Olfr1033
Name: olfactory receptor 1033
Synonyms: GA_x6K02T2Q125-47516301-47517233, MOR199-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258571
Homologene: 138314
Commd4
Name: COMM domain containing 4
Synonyms: 1110039H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66199
VEGA: 9
Homologene: 9865
R3hdm4
Name: R3H domain containing 4
Synonyms: C030046I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 109284
VEGA: 10
Homologene: 16343
Olfr671
Name: olfactory receptor 671
Synonyms: MOR32-12, GA_x6K02T2PBJ9-7604826-7603885
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 257910
Homologene: 133595
Rem1
Name: rad and gem related GTP binding protein 1
Synonyms: E030011C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19700
Homologene: 7514
Med24
Name: mediator complex subunit 24
Synonyms: 100kDa, D11Ertd307e, DRIP100, Thrap4, R75526, Pparb2, Gse2, Trap100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23989
Homologene: 40795
Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Synonyms: 1300010A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 79235
HGNC: HGNC:6685
Homologene: 3483
Cetn4
Name: centrin 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 207175
Homologene: 138302
Olfr110
Name: olfactory receptor 110
Synonyms: GA_x6K02T2PSCP-1956307-1957260, MOR249-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258325
Homologene: 73968
Phactr3
Name: phosphatase and actin regulator 3
Synonyms: 4930415A02Rik, 1500003N10Rik, scapinin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74189
Homologene: 14482
Pcdha2
Name: protocadherin alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 353234
HGNC: HGNC:8668
Homologene: 135719
6330418K02Rik
Name: RIKEN cDNA 6330418K02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69004
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 87,718,066 bp
  • A to G, chromosome 1 at 165,513,140 bp
  • T to C, chromosome 2 at 35,903,123 bp
  • T to C, chromosome 2 at 86,041,951 bp
  • A to G, chromosome 2 at 122,486,869 bp
  • A to G, chromosome 2 at 152,628,057 bp
  • A to G, chromosome 2 at 160,905,016 bp
  • A to G, chromosome 2 at 178,142,461 bp
  • C to T, chromosome 3 at 37,309,945 bp
  • C to T, chromosome 3 at 82,903,220 bp
  • C to A, chromosome 4 at 57,637,876 bp
  • G to T, chromosome 4 at 65,581,786 bp
  • A to G, chromosome 4 at 139,407,772 bp
  • T to C, chromosome 5 at 101,896,559 bp
  • A to G, chromosome 5 at 138,265,780 bp
  • T to C, chromosome 6 at 12,748,800 bp
  • G to A, chromosome 6 at 125,312,794 bp
  • G to T, chromosome 7 at 10,633,950 bp
  • G to T, chromosome 7 at 86,920,122 bp
  • A to T, chromosome 7 at 89,144,664 bp
  • A to T, chromosome 7 at 104,975,228 bp
  • T to C, chromosome 7 at 128,712,660 bp
  • T to C, chromosome 7 at 140,922,190 bp
  • G to A, chromosome 7 at 141,240,937 bp
  • T to A, chromosome 9 at 38,349,862 bp
  • A to G, chromosome 9 at 57,156,806 bp
  • A to G, chromosome 10 at 5,343,473 bp
  • C to T, chromosome 10 at 79,912,458 bp
  • T to C, chromosome 10 at 116,918,848 bp
  • T to C, chromosome 10 at 118,860,738 bp
  • A to G, chromosome 11 at 98,712,559 bp
  • A to G, chromosome 11 at 98,821,471 bp
  • A to G, chromosome 11 at 120,018,768 bp
  • T to C, chromosome 15 at 27,856,194 bp
  • C to A, chromosome 15 at 77,489,087 bp
  • T to C, chromosome 15 at 97,758,861 bp
  • G to A, chromosome 17 at 25,588,669 bp
  • A to T, chromosome 17 at 37,499,439 bp
  • T to C, chromosome 18 at 36,939,862 bp
  • A to T, chromosome 18 at 61,857,225 bp
  • C to T, chromosome 19 at 53,012,238 bp
  • A to G, chromosome Y at 1,336,467 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5442 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043007-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.