Strain Name:
C57BL/6J-MtgxR5501Btlr/Mmmh
Stock Number:
043062-MU
Citation ID:
RRID:MMRRC_043062-MU
Other Names:
R5501 (G1), C57BL/6J-MtgxR5501Btlr
Major Collection:

Gene Information

Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210009
VEGA: 13
HGNC: HGNC:7473
Homologene: 11419
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: SSE, ESP1, separase, Cerp, PRCE, PRCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Sox9
Name: SRY (sex determining region Y)-box 9
Synonyms: 2010306G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20682
Homologene: 294
Map7
Name: microtubule-associated protein 7
Synonyms: ste, mshi, mste, E-MAP-115, Mtap7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Mras
Name: muscle and microspikes RAS
Synonyms: 2900078C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17532
HGNC: HGNC:7227
Homologene: 7424
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Usp15
Name: ubiquitin specific peptidase 15
Synonyms: Gcap18, 4921514G19Rik, E430033I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14479
VEGA: 10
Homologene: 101542
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Ift122
Name: intraflagellar transport 122
Synonyms: sopb, Wdr10, C86139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 81896
Homologene: 12819
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11858
Homologene: 21123
Phrf1
Name: PHD and ring finger domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101471
Homologene: 16377
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: 2900075B16Rik, Efha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78506
Homologene: 15058
Dync1li2
Name: dynein, cytoplasmic 1 light intermediate chain 2
Synonyms: LIC2, Dncli2, Dnclic2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234663
HGNC: HGNC:2966
Homologene: 4474
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213773
Homologene: 4711
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229473
Homologene: 9057
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142980
Homologene: 20696
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: Alox12-ps2, 8-LOX, Alox12-ps1, Aloxe, e-LOX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11685
Homologene: 105868
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Dbr, blanc-sale, Aim1, Aim-1, dominant brown, Oca4, bls, Matp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22293
Homologene: 9412
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Cdt1
Name: chromatin licensing and DNA replication factor 1
Synonyms: 2610318F11Rik, Ris2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67177
Homologene: 32650
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Ifi208
Name: interferon activated gene 208
Synonyms: Pyr-rv1, Pydc3, E430029J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27222
Homologene: 113769
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192193
Homologene: 33836
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76645
Homologene: 124481
Smcp
Name: sperm mitochondria-associated cysteine-rich protein
Synonyms: Mcsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17235
HGNC: HGNC:6962
Adam26a
Name: a disintegrin and metallopeptidase domain 26A (testase 3)
Synonyms: Adam26, Dtgn4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13525
Homologene: 128363
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269437
Homologene: 88833
Olfr1218
Name: olfactory receptor 1218
Synonyms: GA_x6K02T2Q125-50536041-50535106, MOR233-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258815
Homologene: 73986
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Coro6
Name: coronin 6
Synonyms: clipin E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216961
Homologene: 104099
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 171580
Homologene: 11246
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13631
Homologene: 7299
Col25a1
Name: collagen, type XXV, alpha 1
Synonyms: 2700062B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77018
Homologene: 57111
Mmp24
Name: matrix metallopeptidase 24
Synonyms: Membrane type 5-MMP, MT5-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17391
HGNC: HGNC:7172
Homologene: 21331
Olfr478
Name: olfactory receptor 478
Synonyms: MOR204-13, GA_x6K02T2PBJ9-10361879-10360935
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258729
Homologene: 128076
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: PI13, HURPIN, headpin, HUR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Msmo1
Name: methylsterol monoxygenase 1
Synonyms: C78600, Sc4mol, 1500001G16Rik, DESP4, ERG25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66234
Homologene: 133932
Ltb4r1
Name: leukotriene B4 receptor 1
Synonyms: mBLTR, BLTR, BLT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16995
HGNC: HGNC:6713
Homologene: 22477
Olfr849
Name: olfactory receptor 849
Synonyms: GA_x6K02T2PVTD-13176842-13177780, MOR151-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258520
Homologene: 74179
Diras2
Name: DIRAS family, GTP-binding RAS-like 2
Synonyms: 2900052J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68203
VEGA: 13
Homologene: 56777
Vmn2r-ps159
Name: vomeronasal 2, receptor, pseudogene 159
Synonyms: V2r8, Vmn2r-ps160, V2r9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22314
Gm21893
Name: predicted gene, 21893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Igkv4-60
Name: immunoglobulin kappa variable 4-60
Synonyms: Gm10455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 385277
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,551,818 bp
  • A to T, chromosome 1 at 97,840,365 bp
  • T to C, chromosome 1 at 106,982,185 bp
  • A to G, chromosome 1 at 172,246,832 bp
  • G to A, chromosome 1 at 173,678,955 bp
  • A to T, chromosome 2 at 89,054,886 bp
  • C to A, chromosome 2 at 112,662,504 bp
  • T to A, chromosome 2 at 155,798,136 bp
  • A to G, chromosome 3 at 38,887,215 bp
  • G to T, chromosome 3 at 63,707,741 bp
  • G to T, chromosome 3 at 83,926,128 bp
  • A to G, chromosome 3 at 92,584,424 bp
  • A to G, chromosome 3 at 130,595,663 bp
  • T to C, chromosome 4 at 156,334,475 bp
  • A to G, chromosome 6 at 14,719,418 bp
  • T to C, chromosome 6 at 69,463,721 bp
  • T to C, chromosome 6 at 84,087,818 bp
  • T to C, chromosome 6 at 108,843,100 bp
  • C to T, chromosome 6 at 115,905,950 bp
  • A to T, chromosome 6 at 128,294,360 bp
  • G to T, chromosome 7 at 108,032,153 bp
  • A to G, chromosome 7 at 120,889,248 bp
  • T to G, chromosome 7 at 141,259,921 bp
  • C to A, chromosome 8 at 40,354,300 bp
  • A to C, chromosome 8 at 43,569,904 bp
  • C to T, chromosome 8 at 45,398,814 bp
  • A to T, chromosome 8 at 64,722,489 bp
  • A to G, chromosome 8 at 104,440,472 bp
  • T to C, chromosome 8 at 117,065,830 bp
  • C to T, chromosome 8 at 122,570,500 bp
  • T to A, chromosome 9 at 19,440,994 bp
  • T to C, chromosome 9 at 21,121,612 bp
  • A to G, chromosome 9 at 86,507,730 bp
  • A to T, chromosome 9 at 99,411,546 bp
  • T to C, chromosome 10 at 20,276,202 bp
  • G to A, chromosome 10 at 41,486,079 bp
  • T to A, chromosome 10 at 123,175,899 bp
  • G to T, chromosome 11 at 70,316,229 bp
  • T to C, chromosome 11 at 77,467,796 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to C, chromosome 11 at 105,914,985 bp
  • T to A, chromosome 11 at 112,783,859 bp
  • C to T, chromosome 13 at 52,507,750 bp
  • G to T, chromosome 13 at 68,579,647 bp
  • A to G, chromosome 14 at 55,768,082 bp
  • C to T, chromosome 15 at 11,027,785 bp
  • A to G, chromosome 15 at 102,317,130 bp
  • A to T, chromosome 17 at 24,705,127 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5501 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043062-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.