Strain Name:
C57BL/6J-MtgxR5505Btlr/Mmmh
Stock Number:
043066-MU
Citation ID:
RRID:MMRRC_043066-MU
Other Names:
R5505 (G1), C57BL/6J-MtgxR5505Btlr
Major Collection:

Gene Information

Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: Gad-2, 6330404F12Rik, GAD(65), GAD65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Enah
Name: ENAH actin regulator
Synonyms: Mena, Ndpp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13800
Homologene: 134005
Cep290
Name: centrosomal protein 290
Synonyms: b2b1454Clo, Nphp6, Kiaa, b2b1752Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208727
Homologene: 55946
Ints8
Name: integrator complex subunit 8
Synonyms: 2810013E07Rik, D130008D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72656
Homologene: 9888
Rnpc3
Name: RNA-binding region (RNP1, RRM) containing 3
Synonyms: 2810441O16Rik, C030014B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67225
Homologene: 9746
Abcb8
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Srsf5
Name: serine and arginine-rich splicing factor 5
Synonyms: Sfrs5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20384
Homologene: 133842
Prdm15
Name: PR domain containing 15
Synonyms: Zfp298, E130018M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 114604
Homologene: 56941
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: 9530018I07Rik, GnT-IVa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231380
Homologene: 10080
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15467
Homologene: 8290
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: von Ebner minor salivary protein, U46068, LPlunc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228801
Homologene: 50047
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: Pla2epsilon, 2310026J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329502
Homologene: 65339
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: 6530403F17Rik, A530023E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244867
Homologene: 18938
Mmp9
Name: matrix metallopeptidase 9
Synonyms: gelatinase B, Clg4b, Gelatinase B, B/MMP9, MMP-9, Gel B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114875
Homologene: 23815
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Zfp941
Name: zinc finger protein 941
Synonyms: BC066028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 407812
Nlrp12
Name: NLR family, pyrin domain containing 12
Synonyms: Nalp12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 378425
Homologene: 16972
Slc25a30
Name: solute carrier family 25, member 30
Synonyms: KMCP1, 4933433D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67554
VEGA: 14
Homologene: 57046
Ighv1-4
Name: immunoglobulin heavy variable 1-4
Synonyms: Gm16694
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432702
Gpr22
Name: G protein-coupled receptor 22
Synonyms: 2900068K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73010
HGNC: HGNC:4477
Homologene: 18420
Pcnx
Name: pecanex homolog
Synonyms: 2900024E21Rik, 3526401J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Alpk3
Name: alpha-kinase 3
Synonyms: Midori
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 116904
Homologene: 10813
Cmklr1
Name: chemokine-like receptor 1
Synonyms: Gpcr27, ChemR23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Hadhb
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Synonyms: 4930479F15Rik, Mtpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231086
HGNC: HGNC:4803
Homologene: 153
Cckar
Name: cholecystokinin A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12425
HGNC: HGNC:1570
Homologene: 37337
Poldip2
Name: polymerase (DNA-directed), delta interacting protein 2
Synonyms: mitogenin 1, 1300003F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67811
Homologene: 9201
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Rsbn1
Name: rosbin, round spermatid basic protein 1
Synonyms: Rsbp, C230004D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229675
Homologene: 10154
Tle2
Name: transducin-like enhancer of split 2
Synonyms: Grg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21886
Homologene: 20693
Tuba4a
Name: tubulin, alpha 4A
Synonyms: Tuba4, M[a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22145
Homologene: 68496
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: Ccdc7, 4930540C21Rik, 4930517G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74703
Homologene: 134760
Olfr1094
Name: olfactory receptor 1094
Synonyms: GA_x6K02T2Q125-48321457-48322449, MOR179-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258362
Homologene: 133609
Tmem192
Name: transmembrane protein 192
Synonyms: 3110005G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73067
Homologene: 16751
Spag1
Name: sperm associated antigen 1
Synonyms: tpis, TPR-containing protein involved in spermatogenesis
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26942
VEGA: 15
Homologene: 8081
Vmn2r35
Name: vomeronasal 2, receptor 35
Synonyms: EG625353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 625353
Homologene: 113703
Sh3yl1
Name: Sh3 domain YSC-like 1
Synonyms: YSC84, Ray
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24057
Homologene: 31662
Atp23
Name: ATP23 metallopeptidase and ATP synthase assembly factor homolog
Synonyms: 2410012H02Rik, Xrcc6bp1, 1110068E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68876
VEGA: 10
Homologene: 41699
Lrit3
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms: LOC242235
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242235
Homologene: 19426
Gm38400
Name: predicted gene, 38400
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm12843
Name: predicted gene 12843
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 102637763
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,495,954 bp
  • A to G, chromosome 1 at 75,216,416 bp
  • T to C, chromosome 1 at 91,975,465 bp
  • T to A, chromosome 1 at 181,906,453 bp
  • A to T, chromosome 1 at 195,085,380 bp
  • C to G, chromosome 2 at 22,624,833 bp
  • T to C, chromosome 2 at 86,829,501 bp
  • T to C, chromosome 2 at 120,244,775 bp
  • A to G, chromosome 2 at 154,204,779 bp
  • G to A, chromosome 2 at 155,632,672 bp
  • T to C, chromosome 2 at 164,953,608 bp
  • A to T, chromosome 3 at 13,776,920 bp
  • T to A, chromosome 3 at 103,928,943 bp
  • T to C, chromosome 3 at 113,615,453 bp
  • C to T, chromosome 3 at 129,791,438 bp
  • T to A, chromosome 4 at 11,221,143 bp
  • A to C, chromosome 4 at 117,296,091 bp
  • T to A, chromosome 5 at 24,401,038 bp
  • T to C, chromosome 5 at 30,181,040 bp
  • A to G, chromosome 5 at 53,703,068 bp
  • A to G, chromosome 5 at 86,120,546 bp
  • C to G, chromosome 5 at 113,614,929 bp
  • T to C, chromosome 5 at 143,817,990 bp
  • C to G, chromosome 6 at 140,016,216 bp
  • C to T, chromosome 7 at 3,249,385 bp
  • A to T, chromosome 7 at 7,786,480 bp
  • G to A, chromosome 7 at 81,078,561 bp
  • C to T, chromosome 7 at 140,811,917 bp
  • A to G, chromosome 8 at 64,964,246 bp
  • A to G, chromosome 8 at 128,980,174 bp
  • T to A, chromosome 9 at 8,626,735 bp
  • A to G, chromosome 9 at 51,838,948 bp
  • T to A, chromosome 10 at 81,581,740 bp
  • T to C, chromosome 10 at 100,499,186 bp
  • G to T, chromosome 10 at 126,887,630 bp
  • A to G, chromosome 11 at 78,515,175 bp
  • T to A, chromosome 12 at 30,942,073 bp
  • T to C, chromosome 12 at 31,709,725 bp
  • T to C, chromosome 12 at 80,949,083 bp
  • T to C, chromosome 12 at 81,950,153 bp
  • A to G, chromosome 12 at 114,487,437 bp
  • G to A, chromosome 13 at 55,383,238 bp
  • G to A, chromosome 14 at 75,763,349 bp
  • T to C, chromosome 15 at 36,234,626 bp
  • T to A, chromosome 16 at 97,816,983 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5505 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043066-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.