Strain Name:
C57BL/6J-MtgxR5506Btlr/Mmmh
Stock Number:
043067-MU
Citation ID:
RRID:MMRRC_043067-MU
Other Names:
R5506 (G1), C57BL/6J-MtgxR5506Btlr
Major Collection:

Gene Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 268281
Homologene: 6489
Meis1
Name: Meis homeobox 1
Synonyms: C530044H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17268
HGNC: HGNC:7000
Homologene: 86803
Psmb1
Name: proteasome (prosome, macropain) subunit, beta type 1
Synonyms: Lmpc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19170
VEGA: 17
HGNC: HGNC:9537
Homologene: 2087
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 319277
VEGA: 10
Homologene: 123926
Pkn2
Name: protein kinase N2
Synonyms: Stk7, 6030436C20Rik, Prkcl2, PRK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109333
HGNC: HGNC:9406
Homologene: 2054
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Fasn
Name: fatty acid synthase
Synonyms: A630082H08Rik, FAS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, skax26, Cd, ska26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Fam129b
Name: family with sequence similarity 129, member B
Synonyms: 9130404D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227737
Homologene: 11269
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74388
VEGA: 9
Homologene: 57098
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Exosc8
Name: exosome component 8
Synonyms: 2310032N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69639
Homologene: 12323
Gab2
Name: growth factor receptor bound protein 2-associated protein 2
Synonyms: D130058I17Rik, p97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14389
Homologene: 69067
Galr1
Name: galanin receptor 1
Synonyms: Galnr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14427
VEGA: 18
HGNC: HGNC:4132
Homologene: 74396
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: Lpd, C730009O10Rik, lamellipodin, 9430025M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 77300
Homologene: 71030
Gnl2
Name: guanine nucleotide binding protein-like 2 (nucleolar)
Synonyms: Ngp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230737
Homologene: 6858
Serpina10
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Synonyms: PZI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217847
Homologene: 9414
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Nesp2g, nesprin-2, syne-2, dice, Cpfl8, 6820443O06Rik, diminished cone electroretinogram
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319565
Homologene: 56700
Map11
Name: microtubule associated protein 11
Synonyms: BC037034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231807
Homologene: 10106
Slc35b4
Name: solute carrier family 35, member B4
Synonyms: 4930474D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58246
Homologene: 5799
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 102634333
Homologene: 131709
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100040766
Homologene: 85300
Slc20a1
Name: solute carrier family 20, member 1
Synonyms: Glvr1, PiT-1, Glvr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20515
Homologene: 38049
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: Myhse, Myhs-e, MyHC-emb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Capn3
Name: calpain 3
Synonyms: Capa3, Lp82, p94, Capa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Heatr9
Name: HEAT repeat containing 9
Synonyms: Gm11435
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 629303
Homologene: 51895
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330267
Homologene: 46582
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 76482
Homologene: 8341
Scgb2b27
Name: secretoglobin, family 2B, member 27
Synonyms: Abpbg27, Abpbg5, C2a, Abpb, Scgb2b5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233099
Homologene: 83171
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243937
Homologene: 8813
Mc2r
Name: melanocortin 2 receptor
Synonyms: adrenocorticotropic hormone receptor, Acthr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17200
VEGA: 18
HGNC: HGNC:6930
Homologene: 444
Olfr1511
Name: olfactory receptor 1511
Synonyms: GA_x6K02T2RJGY-608749-609705, MOR223-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258268
HGNC: HGNC:8170
Homologene: 87788
Gm8882
Name: predicted gene 8882
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 667929
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: very-kind, 2410012C07Rik, B830014K08Rik, VKIND
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76484
Homologene: 45138
Olfr857
Name: olfactory receptor 857
Synonyms: GA_x6K02T2PVTD-13452606-13453535, MOR146-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 257963
Homologene: 134093
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Fam71f1
Name: family with sequence similarity 71, member F1
Synonyms: LOC330277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330277
Homologene: 13077
CN725425
Name: cDNA sequence CN725425
Synonyms: Gm5807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 545126
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56709
Homologene: 9749
Cant1
Name: calcium activated nucleotidase 1
Synonyms: SCAN-1, D11Bwg0554e, Apy1h, 5830420C20Rik, Shapy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76025
Homologene: 69460
Polr3d
Name: polymerase (RNA) III (DNA directed) polypeptide D
Synonyms: TSBN51, 2810426M17Rik, RPC4, BN51T, 44kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67065
VEGA: 14
HGNC: HGNC:1080
Homologene: 1303
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: GAF1, RIP11, D6Ertd32e, 9130206P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 52055
Homologene: 9158
Plekhb1
Name: pleckstrin homology domain containing, family B (evectins) member 1
Synonyms: PHR1, evt-1, Phret1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 27276
Homologene: 8449
Cep112
Name: centrosomal protein 112
Synonyms: 1700029K01Rik, 8430407H02Rik, Macoco, 1700001M19Rik, Ccdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76380
Homologene: 44915
Sftpb
Name: surfactant associated protein B
Synonyms: SP-B, SF-B, Sftp3, Sftp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20388
Homologene: 456
A930009A15Rik
Name: RIKEN cDNA A930009A15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77798
AC122428.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Cept1
Name: choline/ethanolaminephosphotransferase 1
Synonyms: 9930118K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99712
Homologene: 81624
Trem2
Name: triggering receptor expressed on myeloid cells 2
Synonyms: Trem2a, Trem2b, Trem2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 83433
Homologene: 10352
AL589651.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 60,493,498 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • A to T, chromosome 2 at 13,491,695 bp
  • G to A, chromosome 2 at 32,920,982 bp
  • C to A, chromosome 2 at 57,999,625 bp
  • G to T, chromosome 2 at 120,502,420 bp
  • T to C, chromosome 2 at 129,210,819 bp
  • A to G, chromosome 3 at 54,731,179 bp
  • G to A, chromosome 3 at 95,735,857 bp
  • A to G, chromosome 3 at 106,531,248 bp
  • G to T, chromosome 3 at 138,067,947 bp
  • T to C, chromosome 3 at 142,839,301 bp
  • C to A, chromosome 4 at 125,055,365 bp
  • C to T, chromosome 5 at 138,262,380 bp
  • G to T, chromosome 6 at 12,332,017 bp
  • G to A, chromosome 6 at 29,319,298 bp
  • A to G, chromosome 6 at 34,160,501 bp
  • A to G, chromosome 6 at 72,304,667 bp
  • A to G, chromosome 6 at 85,374,137 bp
  • T to C, chromosome 6 at 132,361,856 bp
  • A to T, chromosome 6 at 134,459,296 bp
  • T to G, chromosome 7 at 34,012,059 bp
  • A to G, chromosome 7 at 37,568,792 bp
  • A to G, chromosome 7 at 97,303,113 bp
  • C to A, chromosome 7 at 100,644,943 bp
  • T to C, chromosome 7 at 135,699,981 bp
  • A to G, chromosome 7 at 139,927,891 bp
  • T to C, chromosome 9 at 19,713,274 bp
  • T to C, chromosome 9 at 44,335,105 bp
  • A to G, chromosome 9 at 65,078,109 bp
  • C to T, chromosome 10 at 11,166,509 bp
  • GC to G, chromosome 10 at 59,892,752 bp
  • A to T, chromosome 10 at 83,581,337 bp
  • G to T, chromosome 10 at 115,578,362 bp
  • T to G, chromosome 11 at 18,941,747 bp
  • T to G, chromosome 11 at 67,084,089 bp
  • T to C, chromosome 11 at 83,514,766 bp
  • A to T, chromosome 11 at 108,664,603 bp
  • G to T, chromosome 11 at 118,411,442 bp
  • C to T, chromosome 11 at 120,809,510 bp
  • A to T, chromosome 12 at 75,938,721 bp
  • T to C, chromosome 12 at 103,626,661 bp
  • A to C, chromosome 13 at 21,786,911 bp
  • T to C, chromosome 14 at 52,390,627 bp
  • A to T, chromosome 14 at 70,440,759 bp
  • C to T, chromosome 15 at 66,028,736 bp
  • A to G, chromosome 15 at 91,235,826 bp
  • A to G, chromosome 16 at 17,293,953 bp
  • A to G, chromosome 17 at 15,490,216 bp
  • T to C, chromosome 17 at 48,351,774 bp
  • A to G, chromosome 18 at 12,188,956 bp
  • A to T, chromosome 18 at 68,407,948 bp
  • T to A, chromosome 18 at 82,405,864 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5506 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043067-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.