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Strain Name:
C57BL/6J-MtgxR5508Btlr/Mmmh
Stock Number:
043069-MU
Citation ID:
RRID:MMRRC_043069-MU
Other Names:
R5508 (G1), C57BL/6J-MtgxR5508Btlr
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Steel Factor Receptor, c-KIT, Dominant white spotting, belly-spot, Tr-kit, SOW3, SCO5, SCO1, Gsfsow3, Gsfsco5, Gsfsco1, CD117
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103573
Homologene: 2554
Ss18l1
Name: SS18, nBAF chromatin remodeling complex subunit like 1
Synonyms: A230053O16Rik, CREST
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269397
Homologene: 9191
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, Cd, ska26, skax26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70355
Homologene: 11099
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83691
Homologene: 12857
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: Min, CC1, adenomatosis polyposis coli
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72776
Homologene: 45668
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, TFIIIC-BETA, TFIIIC110, 1300004C11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Pdcd2
Name: programmed cell death 2
Synonyms: RP-8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18567
HGNC: HGNC:8762
Homologene: 1951
Large2
Name: LARGE xylosyl- and glucuronyltransferase 2
Synonyms: 5730485C17Rik, Gyltl1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228366
Homologene: 27362
Clec4b2
Name: C-type lectin domain family 4, member b2
Synonyms: mDCAR1, F830043G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381809
Homologene: 128249
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Trim80
Name: tripartite motif-containing 80
Synonyms: 4933422H20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432613
Homologene: 46325
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
BC016579
Name: cDNA sequence, BC016579
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212998
VEGA: 16
Homologene: 11622
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72094
Homologene: 55988
Scoc
Name: short coiled-coil protein
Synonyms: short coiled-coil protein, 0610011C06Rik, 2810002J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56367
Homologene: 134118
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67307
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Prr36
Name: proline rich 36
Synonyms: BC068157
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73072
Homologene: 136398
Asphd2
Name: aspartate beta-hydroxylase domain containing 2
Synonyms: 9230106G13Rik, 2900006N09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72898
Homologene: 10717
Dnase1l3
Name: deoxyribonuclease 1-like 3
Synonyms: DNasegamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13421
HGNC: HGNC:2959
Homologene: 3630
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 194126
Homologene: 82382
Csn1s2b
Name: casein alpha s2-like B
Synonyms: Csne, Csnd
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12992
Homologene: 49221
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: SPEER-3, 4933405P08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71026
Homologene: 69402
Tubb5
Name: tubulin, beta 5 class I
Synonyms: B130022C14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22154
Homologene: 69099
Efhd1
Name: EF hand domain containing 1
Synonyms: PP3051, 4931430I01Rik, mitocalcin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98363
Homologene: 41618
Bcl6b
Name: B cell CLL/lymphoma 6, member B
Synonyms: Bazf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12029
HGNC: HGNC:1002
Homologene: 7243
Klf14
Name: Kruppel-like transcription factor 14
Synonyms: BTEB5, 5330411L03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619665
Homologene: 76469
A230020J21Rik
Name: RIKEN cDNA A230020J21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100125339
4930511M06Rik
Name: RIKEN cDNA 4930511M06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75084
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 17,752,983 bp
  • A to G, chromosome 1 at 87,309,794 bp
  • G to T, chromosome 1 at 106,364,390 bp
  • G to A, chromosome 1 at 128,294,131 bp
  • C to T, chromosome 1 at 191,025,459 bp
  • T to A, chromosome 2 at 32,288,187 bp
  • T to C, chromosome 2 at 41,728,728 bp
  • G to A, chromosome 2 at 71,227,821 bp
  • A to G, chromosome 2 at 92,369,903 bp
  • C to G, chromosome 2 at 180,057,653 bp
  • G to A, chromosome 3 at 96,163,767 bp
  • G to A, chromosome 3 at 116,620,103 bp
  • T to A, chromosome 5 at 13,794,664 bp
  • G to T, chromosome 5 at 31,174,461 bp
  • G to T, chromosome 5 at 75,649,548 bp
  • A to T, chromosome 5 at 87,327,200 bp
  • A to G, chromosome 5 at 87,813,153 bp
  • A to T, chromosome 5 at 112,386,783 bp
  • T to C, chromosome 6 at 30,958,042 bp
  • A to G, chromosome 6 at 123,173,042 bp
  • T to G, chromosome 6 at 134,464,516 bp
  • T to A, chromosome 7 at 42,266,818 bp
  • G to A, chromosome 8 at 4,216,488 bp
  • A to T, chromosome 8 at 83,435,942 bp
  • T to A, chromosome 10 at 58,480,005 bp
  • T to A, chromosome 10 at 63,066,665 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • T to C, chromosome 10 at 86,960,279 bp
  • C to A, chromosome 10 at 107,686,231 bp
  • A to G, chromosome 11 at 23,294,645 bp
  • A to T, chromosome 11 at 70,226,093 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • T to A, chromosome 11 at 115,445,078 bp
  • A to G, chromosome 14 at 7,968,146 bp
  • T to A, chromosome 16 at 45,633,006 bp
  • C to T, chromosome 17 at 15,521,739 bp
  • T to C, chromosome 17 at 35,835,070 bp
  • A to G, chromosome 18 at 34,298,580 bp
  • A to T, chromosome 18 at 37,301,126 bp
  • G to A, chromosome 18 at 57,538,084 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5508 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043069-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.