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Strain Name:
C57BL/6J-MtgxR5543Btlr/Mmmh
Stock Number:
043101-MU
Citation ID:
RRID:MMRRC_043101-MU
Other Names:
R5543 (G1), C57BL/6J-MtgxR5543Btlr
Major Collection:

Strain Information

Kifc2
Name: kinesin family member C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16581
VEGA: 15
Homologene: 7800
Zfp143
Name: zinc finger protein 143
Synonyms: D7Ertd805e, pHZ-1, KRAB14, Zfp79, Zfp80-rs1, Staf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20841
Homologene: 56444
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Apod
Name: apolipoprotein D
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11815
HGNC: HGNC:612
Homologene: 1246
Esrrg
Name: estrogen-related receptor gamma
Synonyms: estrogen-related receptor 3, ERR3, Errg, NR3B3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26381
HGNC: HGNC:3474
Homologene: 55581
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, 4933439E17Rik, 4930513H15Rik, D14Ertd581e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Slc37a3
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 3
Synonyms: 2610507O21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72144
Homologene: 41740
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Gabrr3
Name: gamma-aminobutyric acid type A receptor subunit rho 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Lrfn4
Name: leucine rich repeat and fibronectin type III domain containing 4
Synonyms: SALM3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225875
Homologene: 36415
Izumo4
Name: IZUMO family member 4
Synonyms: 9030607L17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71564
VEGA: 10
Homologene: 50465
E130114P18Rik
Name: RIKEN cDNA E130114P18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319865
Acvr1
Name: activin A receptor, type 1
Synonyms: ActR-I, ALK2, Acvr, Acvrlk2, ActRIA, SKR1, Tsk7L, D330013D15Rik, Alk8, Alk-2, Acvr1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Atp5po
Name: ATP synthase peripheral stalk subunit OSCP
Synonyms: D12Wsu28e, Atp5o
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 28080
HGNC: HGNC:850
Homologene: 1283
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Aak1
Name: AP2 associated kinase 1
Synonyms: 5530400K14Rik, D6Ertd245e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Vamp3
Name: vesicle-associated membrane protein 3
Synonyms: cellubrevin, D130027G05Rik, VAMP-3, ceb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22319
Homologene: 3511
Fchsd2
Name: FCH and double SH3 domains 2
Synonyms: Sh3md3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207278
Homologene: 8887
Pla2g15
Name: phospholipase A2, group XV
Synonyms: LLPL, C87498, Lpla2, Lypla3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 192654
Homologene: 8200
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Or1n2
Name: olfactory receptor family 1 subfamily N member 2
Synonyms: GA_x6K02T2NLDC-33601476-33602429, MOR127-4, Olfr354
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258941
Homologene: 17443
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Ankrd33b
Name: ankyrin repeat domain 33B
Synonyms: 0610012A05Rik, 5730557B15Rik, 3021401C12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67434
Homologene: 12362
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Abcc6
Name: ATP-binding cassette, sub-family C member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Shbg
Name: sex hormone binding globulin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20415
Homologene: 813
Pitpnm3
Name: PITPNM family member 3
Synonyms: A330068P14Rik, Ackr6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327958
Homologene: 66271
Trbv15
Name: T cell receptor beta, variable 15
Synonyms: Gm16775, Tcrb-V12
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124679
Mmp15
Name: matrix metallopeptidase 15
Synonyms: MT2-MMP, Membrane type 2-MMP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Plxnc1
Name: plexin C1
Synonyms: vespr, 2510048K12Rik, CD232
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Or5m12
Name: olfactory receptor family 5 subfamily M member 12
Synonyms: GA_x6K02T2Q125-47384320-47383337, MOR197-1, Olfr1024
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257900
Homologene: 128271
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: 1600029O10Rik, collaborator of Stat6, CoaSt6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 547253
Homologene: 19697
Zfp438
Name: zinc finger protein 438
Synonyms: 9430091M14Rik, B830013J05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240186
VEGA: 18
Homologene: 18695
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Zfp696
Name: zinc finger protein 696
Synonyms: 9130023H24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043133
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69387
Homologene: 70141
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: MTPCR07, MOR281-1, GA_x6K02T2NKPP-957001-957948, Olfr30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18329
Homologene: 131139
Ldha
Name: lactate dehydrogenase A
Synonyms: lactate dehydrogenase-A, LDH-A, Ldh-1, l7R2, Ldh1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16828
HGNC: HGNC:6535
Homologene: 56495
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Ugt2b34
Name: UDP glucuronosyltransferase 2 family, polypeptide B34
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100727
Homologene: 117389
Ifitm3
Name: interferon induced transmembrane protein 3
Synonyms: mil-1, 1110004C05Rik, Fgls, IP15, fragilis
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66141
HGNC: HGNC:5414
Homologene: 136199
Hrh3
Name: histamine receptor H3
Synonyms: Eae8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99296
HGNC: HGNC:5184
Homologene: 5232
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237886
Homologene: 45432
Spmip10
Name: sperm microtubule inner protein 10
Synonyms: 1700065I17Rik, Tex43
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67343
Homologene: 77918
Fam240b
Name: family with sequence similarity 240 member B
Synonyms: 1190003K10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68880
Ighv1-14
Name: immunoglobulin heavy variable 1-14
Synonyms: Gm16857
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629863
Gm3030
Name: predicted gene 3030
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108168185
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,504,069 bp
  • G to A, chromosome 1 at 162,673,511 bp
  • A to T, chromosome 1 at 188,150,254 bp
  • C to T, chromosome 2 at 36,907,357 bp
  • A to G, chromosome 2 at 58,463,145 bp
  • C to T, chromosome 2 at 76,739,574 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • G to T, chromosome 2 at 85,904,328 bp
  • G to T, chromosome 2 at 180,103,970 bp
  • A to T, chromosome 4 at 11,194,026 bp
  • T to C, chromosome 4 at 76,059,753 bp
  • C to T, chromosome 4 at 97,690,704 bp
  • C to T, chromosome 4 at 126,841,224 bp
  • A to G, chromosome 4 at 151,051,020 bp
  • T to A, chromosome 5 at 86,906,701 bp
  • A to G, chromosome 5 at 96,528,535 bp
  • T to A, chromosome 5 at 104,489,333 bp
  • T to A, chromosome 5 at 105,017,830 bp
  • T to C, chromosome 5 at 108,670,229 bp
  • C to A, chromosome 6 at 39,355,026 bp
  • A to T, chromosome 6 at 41,141,253 bp
  • T to C, chromosome 6 at 86,982,645 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • A to G, chromosome 7 at 45,989,536 bp
  • A to T, chromosome 7 at 46,850,890 bp
  • A to G, chromosome 7 at 100,504,546 bp
  • T to C, chromosome 7 at 101,271,699 bp
  • T to A, chromosome 7 at 110,083,315 bp
  • C to A, chromosome 7 at 128,237,181 bp
  • T to A, chromosome 7 at 141,009,817 bp
  • T to A, chromosome 8 at 45,023,479 bp
  • T to C, chromosome 8 at 95,368,101 bp
  • T to C, chromosome 8 at 106,161,143 bp
  • T to A, chromosome 9 at 111,366,112 bp
  • A to T, chromosome 9 at 119,173,608 bp
  • A to T, chromosome 10 at 76,412,052 bp
  • T to C, chromosome 10 at 80,702,834 bp
  • G to T, chromosome 10 at 94,864,774 bp
  • T to A, chromosome 11 at 58,455,167 bp
  • A to G, chromosome 11 at 69,616,738 bp
  • A to G, chromosome 11 at 72,056,197 bp
  • C to A, chromosome 11 at 82,982,381 bp
  • T to C, chromosome 12 at 114,646,858 bp
  • T to A, chromosome 13 at 64,485,922 bp
  • C to A, chromosome 13 at 113,320,873 bp
  • T to C, chromosome 14 at 4,536,957 bp
  • A to T, chromosome 14 at 99,112,992 bp
  • T to C, chromosome 15 at 31,323,881 bp
  • A to G, chromosome 15 at 76,667,042 bp
  • T to C, chromosome 15 at 89,532,354 bp
  • T to C, chromosome 16 at 31,303,533 bp
  • T to C, chromosome 16 at 35,834,767 bp
  • T to C, chromosome 16 at 59,433,507 bp
  • T to C, chromosome 16 at 91,926,530 bp
  • T to C, chromosome 16 at 93,798,920 bp
  • A to G, chromosome 17 at 24,447,362 bp
  • T to C, chromosome 18 at 5,213,761 bp
  • G to A, chromosome 18 at 56,594,688 bp
  • T to C, chromosome 19 at 4,612,163 bp
  • C to T, chromosome 19 at 37,981,330 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5543 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043101-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.