Strain Name:
C57BL/6J-MtgxR5543Btlr/Mmmh
Stock Number:
043101-MU
Citation ID:
RRID:MMRRC_043101-MU
Other Names:
R5543 (G1), C57BL/6J-MtgxR5543Btlr
Major Collection:

Gene Information

Kifc2
Name: kinesin family member C2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16581
VEGA: 15
Homologene: 7800
Zfp143
Name: zinc finger protein 143
Synonyms: Staf, Zfp80-rs1, Zfp79, KRAB14, D7Ertd805e, pHZ-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20841
Homologene: 56444
Ccne2
Name: cyclin E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12448
HGNC: HGNC:1590
Homologene: 7660
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: Dopey2, 0610038M01Rik, 2610510B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Apod
Name: apolipoprotein D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11815
HGNC: HGNC:612
Homologene: 1246
Esrrg
Name: estrogen-related receptor gamma
Synonyms: Errg, estrogen-related receptor 3, ERR3, NR3B3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26381
HGNC: HGNC:3474
Homologene: 55581
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 4933438D16Rik, D14Ertd581e, 4933439E17Rik, 4930513H15Rik, 1700017E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Slc37a3
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 3
Synonyms: 2610507O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72144
Homologene: 41740
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, m239Asp, Pcnt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, Bat2l2, Bat2d, 1810043M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Gabrr3
Name: gamma-aminobutyric acid (GABA) receptor, rho 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Lrfn4
Name: leucine rich repeat and fibronectin type III domain containing 4
Synonyms: SALM3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225875
Homologene: 36415
Izumo4
Name: IZUMO family member 4
Synonyms: 9030607L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71564
VEGA: 10
Homologene: 50465
E130114P18Rik
Name: RIKEN cDNA E130114P18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319865
Acvr1
Name: activin A receptor, type 1
Synonyms: Tsk7L, D330013D15Rik, ActRIA, Acvr, ALK2, ActR-I, Acvr1a, Alk8, SKR1, Acvrlk2, Alk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Atp5o
Name: ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
Synonyms: D12Wsu28e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 28080
HGNC: HGNC:850
Homologene: 1283
Fat1
Name: FAT atypical cadherin 1
Synonyms: 2310038E12Rik, mFat1, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269774
Homologene: 128746
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: C030034P18Rik, TRPP2, PC2, polycystin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Vamp3
Name: vesicle-associated membrane protein 3
Synonyms: VAMP-3, ceb, cellubrevin, D130027G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22319
Homologene: 3511
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100317
Homologene: 11764
Fchsd2
Name: FCH and double SH3 domains 2
Synonyms: Sh3md3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207278
Homologene: 8887
Pla2g15
Name: phospholipase A2, group XV
Synonyms: C87498, Lpla2, LLPL, Lypla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 192654
Homologene: 8200
Myof
Name: myoferlin
Synonyms: Fer1l3, 2310051D19Rik, E030042N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Ttn
Name: titin
Synonyms: mdm, 2310036G12Rik, D830007G01Rik, shru, L56, 2310074I15Rik, 2310057K23Rik, connectin, D330041I19Rik, 1100001C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
BC067074
Name: cDNA sequence BC067074
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408066
Olfr354
Name: olfactory receptor 354
Synonyms: GA_x6K02T2NLDC-33601476-33602429, MOR127-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258941
Homologene: 17443
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 1110002J03Rik, B230219D21Rik, 3000002J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: LOC235639, C030048J01Rik, Lba1, A230061D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Ankrd33b
Name: ankyrin repeat domain 33B
Synonyms: 5730557B15Rik, 3021401C12Rik, 0610012A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67434
Homologene: 12362
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: Mrp6, DCC, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Shbg
Name: sex hormone binding globulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20415
Homologene: 813
Pitpnm3
Name: PITPNM family member 3
Synonyms: A330068P14Rik, Ackr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327958
Homologene: 66271
Trbv15
Name: T cell receptor beta, variable 15
Synonyms: Gm16775, Tcrb-V12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124679
Mmp15
Name: matrix metallopeptidase 15
Synonyms: MT2-MMP, Membrane type 2-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Plxnc1
Name: plexin C1
Synonyms: 2510048K12Rik, CD232, vespr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Olfr1024
Name: olfactory receptor 1024
Synonyms: MOR197-1, GA_x6K02T2Q125-47384320-47383337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257900
Homologene: 128271
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 58234
Homologene: 75163
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: collaborator of Stat6, 1600029O10Rik, CoaSt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Zfp438
Name: zinc finger protein 438
Synonyms: B830013J05Rik, 9430091M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240186
VEGA: 18
Homologene: 18695
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
9130023H24Rik
Name: RIKEN cDNA 9130023H24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043133
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69387
Homologene: 70141
Olfr30
Name: olfactory receptor 30
Synonyms: MOR281-1, MTPCR07, GA_x6K02T2NKPP-957001-957948
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18329
Homologene: 131139
Ldha
Name: lactate dehydrogenase A
Synonyms: lactate dehydrogenase-A, l7R2, LDH-A, Ldh1, Ldh-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16828
HGNC: HGNC:6535
Homologene: 56495
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76074
Ugt2b34
Name: UDP glucuronosyltransferase 2 family, polypeptide B34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100727
Homologene: 117389
Ifitm3
Name: interferon induced transmembrane protein 3
Synonyms: mil-1, fragilis, Fgls, IP15, 1110004C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66141
HGNC: HGNC:5414
Homologene: 136199
Hrh3
Name: histamine receptor H3
Synonyms: Eae8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99296
HGNC: HGNC:5184
Homologene: 5232
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237886
Homologene: 45432
Tex43
Name: testis expressed 43
Synonyms: 1700065I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67343
Homologene: 77918
Fam240b
Name: family with sequence similarity 240 member B
Synonyms: 1190003K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68880
Ighv1-14
Name: immunoglobulin heavy variable 1-14
Synonyms: Gm16857
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629863
Gm3030
Name: predicted gene 3030
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108168185
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,504,069 bp
  • G to A, chromosome 1 at 162,673,511 bp
  • A to T, chromosome 1 at 188,150,254 bp
  • C to T, chromosome 2 at 36,907,357 bp
  • A to G, chromosome 2 at 58,463,145 bp
  • C to T, chromosome 2 at 76,739,574 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • G to T, chromosome 2 at 85,904,328 bp
  • G to T, chromosome 2 at 180,103,970 bp
  • A to T, chromosome 4 at 11,194,026 bp
  • T to C, chromosome 4 at 76,059,753 bp
  • C to T, chromosome 4 at 97,690,704 bp
  • C to T, chromosome 4 at 126,841,224 bp
  • A to G, chromosome 4 at 151,051,020 bp
  • T to A, chromosome 5 at 86,906,701 bp
  • A to G, chromosome 5 at 96,528,535 bp
  • T to A, chromosome 5 at 104,489,333 bp
  • T to A, chromosome 5 at 105,017,830 bp
  • T to C, chromosome 5 at 108,670,229 bp
  • C to A, chromosome 6 at 39,355,026 bp
  • A to T, chromosome 6 at 41,141,253 bp
  • T to C, chromosome 6 at 86,982,645 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • A to G, chromosome 7 at 45,989,536 bp
  • A to T, chromosome 7 at 46,850,890 bp
  • A to G, chromosome 7 at 100,504,546 bp
  • T to C, chromosome 7 at 101,271,699 bp
  • T to A, chromosome 7 at 110,083,315 bp
  • C to A, chromosome 7 at 128,237,181 bp
  • T to A, chromosome 7 at 141,009,817 bp
  • T to A, chromosome 8 at 45,023,479 bp
  • T to C, chromosome 8 at 95,368,101 bp
  • T to C, chromosome 8 at 106,161,143 bp
  • T to A, chromosome 9 at 111,366,112 bp
  • A to T, chromosome 9 at 119,173,608 bp
  • A to T, chromosome 10 at 76,412,052 bp
  • T to C, chromosome 10 at 80,702,834 bp
  • G to T, chromosome 10 at 94,864,774 bp
  • T to A, chromosome 11 at 58,455,167 bp
  • A to G, chromosome 11 at 69,616,738 bp
  • A to G, chromosome 11 at 72,056,197 bp
  • C to A, chromosome 11 at 82,982,381 bp
  • T to C, chromosome 12 at 114,646,858 bp
  • T to A, chromosome 13 at 64,485,922 bp
  • C to A, chromosome 13 at 113,320,873 bp
  • T to C, chromosome 14 at 4,536,957 bp
  • A to T, chromosome 14 at 99,112,992 bp
  • T to C, chromosome 15 at 31,323,881 bp
  • A to G, chromosome 15 at 76,667,042 bp
  • T to C, chromosome 15 at 89,532,354 bp
  • T to C, chromosome 16 at 31,303,533 bp
  • T to C, chromosome 16 at 35,834,767 bp
  • T to C, chromosome 16 at 59,433,507 bp
  • T to C, chromosome 16 at 91,926,530 bp
  • T to C, chromosome 16 at 93,798,920 bp
  • A to G, chromosome 17 at 24,447,362 bp
  • T to C, chromosome 18 at 5,213,761 bp
  • G to A, chromosome 18 at 56,594,688 bp
  • T to C, chromosome 19 at 4,612,163 bp
  • C to T, chromosome 19 at 37,981,330 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5543 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043101-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.