Strain Name:
C57BL/6J-MtgxR5552Btlr/Mmmh
Stock Number:
043109-MU
Citation ID:
RRID:MMRRC_043109-MU
Other Names:
R5552 (G1), C57BL/6J-MtgxR5552Btlr
Major Collection:

Strain Information

Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp5, Zfp-5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, PBP, CRSP210, DRIP205, Pparbp, l11Jus15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: l(7)1Rl, pl-1, P140SRA-1, E030028J09Rik, Sra-1, Shyc, l7Rl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20430
Homologene: 22628
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: KMT4, mDot1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Csnk1g3
Name: casein kinase 1, gamma 3
Synonyms: 3300002K07Rik, C330049O21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70425
VEGA: 18
HGNC: HGNC:2456
Homologene: 121650
Glipr1l1
Name: GLI pathogenesis-related 1 like 1
Synonyms: 1700011E04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69286
VEGA: 10
Homologene: 83452
Htt
Name: huntingtin
Synonyms: Hdh, huntingtin, htt, HD, IT15, C430023I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Arhgap19
Name: Rho GTPase activating protein 19
Synonyms: 4933411B03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71085
Homologene: 13159
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Blzf1
Name: basic leucine zipper nuclear factor 1
Synonyms: Jem-1, Blzf1l, Golgin-45, 1700030G05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66352
HGNC: HGNC:1065
Homologene: 31187
Zfp280b
Name: zinc finger protein 280B
Synonyms: Suhw2, D10Jhu82e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64453
VEGA: 10
Homologene: 62794
Pde4a
Name: phosphodiesterase 4A, cAMP specific
Synonyms: Dpde2, dunce, D9Ertd60e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18577
HGNC: HGNC:8780
Homologene: 4520
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: CHAMP, Csm
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Pmpcb
Name: peptidase (mitochondrial processing) beta
Synonyms: MPPP52, 3110004O18Rik, MPP11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73078
HGNC: HGNC:9119
Homologene: 3160
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Enpep
Name: glutamyl aminopeptidase
Synonyms: 6030431M22Rik, Bp-1/6C3, Ly51, aminopeptidase-A, Ly-51, APA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Csn1s1
Name: casein alpha s1
Synonyms: Csna
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12990
HGNC: HGNC:2445
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Dlgap2
Name: DLG associated protein 2
Synonyms: DAP2, Sapap2, 6430596N04Rik, SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: alpha-1 antiproteinase,, Spi2/eb.1, Spi2A, 2A2, Spi2-1, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: Armc4, 4930463I21Rik, b2b643Clo, b2b227.1Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Serac1
Name: serine active site containing 1
Synonyms: 4930511N22Rik, D17Ertd141e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321007
Homologene: 41900
Or10ak9
Name: olfactory receptor family 10 subfamily AK member 9
Synonyms: MOR259-3P, Olfr1331, GA_x6K02T2QD9B-18670866-18669913
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258159
Homologene: 134082
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: 4930532L22Rik, B230399N07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: F830007N14Rik, Card4, Nlrc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107607
Homologene: 4440
Cdh2
Name: cadherin 2
Synonyms: N-CAD, Ncad, N-cadherin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Tbrg1
Name: transforming growth factor beta regulated gene 1
Synonyms: TB-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21376
Homologene: 18102
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Mrrf
Name: mitochondrial ribosome recycling factor
Synonyms: 2400002D02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67871
HGNC: HGNC:7234
Homologene: 12203
Or6c69c
Name: olfactory receptor family 6 subfamily C member 69C
Synonyms: Olfr822, MOR113-2, GA_x6K02T2PULF-11745102-11746040
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258666
Homologene: 133890
Abtb1
Name: ankyrin repeat and BTB domain containing 1
Synonyms: BPOZ, EF1ABP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80283
Homologene: 32731
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Ankrd39
Name: ankyrin repeat domain 39
Synonyms: 9130416N05Rik, C030004B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109346
Homologene: 9519
Pramel51
Name: PRAME like 51
Synonyms: Gm10436
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039315
VEGA: 12
Homologene: 103830
H3c4
Name: H3 clustered histone 4
Synonyms: H3-b, Hist1h3d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319149
Homologene: 134332
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 36,541,981 bp
  • A to T, chromosome 1 at 164,302,489 bp
  • T to C, chromosome 2 at 14,279,957 bp
  • T to A, chromosome 2 at 36,147,961 bp
  • T to C, chromosome 3 at 89,365,066 bp
  • T to C, chromosome 3 at 129,312,565 bp
  • T to A, chromosome 4 at 118,869,468 bp
  • T to C, chromosome 4 at 136,931,899 bp
  • T to A, chromosome 4 at 152,385,815 bp
  • C to T, chromosome 5 at 21,757,023 bp
  • A to G, chromosome 5 at 34,821,774 bp
  • T to A, chromosome 5 at 87,675,059 bp
  • A to T, chromosome 5 at 107,818,989 bp
  • A to G, chromosome 5 at 108,683,065 bp
  • T to A, chromosome 5 at 121,342,851 bp
  • A to G, chromosome 6 at 54,944,631 bp
  • G to T, chromosome 6 at 82,730,823 bp
  • A to G, chromosome 6 at 88,836,548 bp
  • A to G, chromosome 6 at 146,294,080 bp
  • T to C, chromosome 7 at 55,872,107 bp
  • G to T, chromosome 8 at 14,831,342 bp
  • T to A, chromosome 8 at 109,531,751 bp
  • T to C, chromosome 9 at 21,201,386 bp
  • T to C, chromosome 9 at 37,652,693 bp
  • C to T, chromosome 10 at 76,039,663 bp
  • CCAGCCCCACCCTCAGCC to CCAGCC, chromosome 10 at 80,783,628 bp
  • A to T, chromosome 10 at 112,062,338 bp
  • C to A, chromosome 10 at 127,330,262 bp
  • T to C, chromosome 10 at 130,075,145 bp
  • A to T, chromosome 11 at 98,166,331 bp
  • T to A, chromosome 12 at 88,178,365 bp
  • T to C, chromosome 12 at 104,240,336 bp
  • A to G, chromosome 13 at 23,576,121 bp
  • T to C, chromosome 15 at 76,599,646 bp
  • T to A, chromosome 15 at 89,054,366 bp
  • A to G, chromosome 16 at 37,094,510 bp
  • T to A, chromosome 17 at 6,056,692 bp
  • A to C, chromosome 17 at 84,429,130 bp
  • A to G, chromosome 18 at 7,285,360 bp
  • T to C, chromosome 18 at 16,640,463 bp
  • T to C, chromosome 18 at 53,932,283 bp
  • T to C, chromosome 19 at 41,784,380 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5552 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043109-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.