Strain Name:
C57BL/6J-MtgxR5562Btlr/Mmmh
Stock Number:
043119-MU
Citation ID:
RRID:MMRRC_043119-MU
Other Names:
R5562 (G1), C57BL/6J-MtgxR5562Btlr
Major Collection:

Gene Information

Prnp
Name: prion protein
Synonyms: Prn-i, Sinc, CD230, PrPC, PrP, Prn-p, PrPSc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19122
HGNC: HGNC:9449
Homologene: 7904
Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54445
Homologene: 41325
Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20540
Homologene: 88701
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330177
Homologene: 83279
Utp4
Name: UTP4 small subunit processome component
Synonyms: TEG-292, Tex292, Cirh1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21771
HGNC: HGNC:1983
Homologene: 40775
Kif15
Name: kinesin family member 15
Synonyms: 3110023M17Rik, HKLP2, 3930402I10Rik, N-10 kinesin, Knsl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: BIG1, D130059B05Rik, D730028O18Rik, P200, ARFGEP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22722
Homologene: 7604
Slc30a6
Name: solute carrier family 30 (zinc transporter), member 6
Synonyms: ZnT6, ZnT-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210148
VEGA: 17
Homologene: 32380
Tank
Name: TRAF family member-associated Nf-kappa B activator
Synonyms: E430026L09Rik, I-TRAF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21353
Homologene: 3081
Amotl1
Name: angiomotin-like 1
Synonyms: 2310067L22Rik, 4932416D09Rik, 2310010G08Rik, JEAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75723
Homologene: 43977
Arih2
Name: ariadne RBR E3 ubiquitin protein ligase 2
Synonyms: TRIAD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23807
HGNC: HGNC:690
Homologene: 48424
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 3200002M13Rik, 1110028I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Tmem183a
Name: transmembrane protein 183A
Synonyms: 1300007B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57439
Homologene: 10757
Serinc1
Name: serine incorporator 1
Synonyms: Tde1l, 1500011D18Rik, Tde2, TMS-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56442
Homologene: 41334
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277463
Homologene: 81077
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216742
Homologene: 28173
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: 9830168K16Rik, TRPC7, Trrp7, LTRPC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28240
Homologene: 20709
Trim55
Name: tripartite motif-containing 55
Synonyms: Murf2, D830041C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381485
Homologene: 13205
Ttn
Name: titin
Synonyms: 2310036G12Rik, mdm, 1100001C23Rik, shru, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, L56, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: mRib72-1, 1700029F22Rik, myoclonin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71877
Homologene: 10003
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434377
Homologene: 103820
Ush2a
Name: usherin
Synonyms: Ushrn, A930011D15Rik, Ush2a, LOC269160, MUSH2A, A930037M10Rik, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Car4
Name: carbonic anhydrase 4
Synonyms: CA IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12351
HGNC: HGNC:1375
Homologene: 20183
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Slc13a5
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms: Indy, Nact, mINDY, NaC2/NaCT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237831
Homologene: 21941
Cdhr3
Name: cadherin-related family member 3
Synonyms: 1110049B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68764
VEGA: 12
Homologene: 45146
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC9, MUC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Masp1
Name: mannan-binding lectin serine peptidase 1
Synonyms: Crarf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Speg
Name: SPEG complex locus
Synonyms: SPEG, Apeg1, BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26358
HGNC: HGNC:402
Homologene: 137245
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Unc5c
Name: unc-5 netrin receptor C
Synonyms: B130051O18Rik, Unc5h3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22253
Homologene: 2765
Foxc1
Name: forkhead box C1
Synonyms: fkh-1, FREAC3, Mf4, fkh1, frkhda, Fkh1, Mf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17300
HGNC: HGNC:3800
Homologene: 20373
4930451G09Rik
Name: RIKEN cDNA 4930451G09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74684
VEGA: 16
Alkbh3
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
Synonyms: mABH3, 1810020C19Rik, Abh3, 1700108H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69113
Homologene: 16393
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: Ccdc7, 4930540C21Rik, 4930517G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74703
Homologene: 134760
Nudt7
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 7
Synonyms: 1300007B24Rik, 2210404C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67528
HGNC: HGNC:8054
Homologene: 41564
Elovl2
Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
Synonyms: Ssc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54326
Homologene: 23042
Cyp2j8
Name: cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms: Cyp2j8-ps, OTTMUSG00000007938
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665095
Homologene: 133819
Ncoa4-ps
Name: nuclear receptor coactivator 4, pseudogene
Synonyms: Gm6768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 627557
VEGA: 12
Dcstamp
Name: dendrocyte expressed seven transmembrane protein
Synonyms: DC-STAMP, 4833414I07Rik, Tm7sf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75766
VEGA: 15
Homologene: 12769
Olfr1133
Name: olfactory receptor 1133
Synonyms: GA_x6K02T2Q125-49151278-49150337, MOR176-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258348
Slc9a3r2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
Synonyms: 2010007A20Rik, Sip1, E3karp, Sip-1, 0610011L07Rik, Tka-1, Sryip1, Octs2, Nherf2, 1200011K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 65962
VEGA: 17
Homologene: 56962
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Gm10603
Name: predicted gene 10603
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100038497
Gm6457
Name: predicted pseudogene 6457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 623867
VEGA: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,144,746 bp
  • C to T, chromosome 1 at 20,972,880 bp
  • T to A, chromosome 1 at 75,427,056 bp
  • C to A, chromosome 1 at 134,350,197 bp
  • T to A, chromosome 1 at 188,576,217 bp
  • C to T, chromosome 2 at 31,152,363 bp
  • A to G, chromosome 2 at 61,650,208 bp
  • A to T, chromosome 2 at 76,770,459 bp
  • T to C, chromosome 2 at 76,889,317 bp
  • T to C, chromosome 2 at 87,645,719 bp
  • A to T, chromosome 2 at 93,996,379 bp
  • A to G, chromosome 2 at 131,937,031 bp
  • A to G, chromosome 2 at 168,925,722 bp
  • A to T, chromosome 3 at 19,659,153 bp
  • A to G, chromosome 3 at 141,768,530 bp
  • A to G, chromosome 4 at 96,470,653 bp
  • T to A, chromosome 5 at 117,250,964 bp
  • T to C, chromosome 7 at 100,448,700 bp
  • T to C, chromosome 7 at 141,847,238 bp
  • G to A, chromosome 8 at 106,922,925 bp
  • C to A, chromosome 8 at 114,147,983 bp
  • T to C, chromosome 8 at 129,058,785 bp
  • G to A, chromosome 9 at 14,575,297 bp
  • G to T, chromosome 9 at 20,350,587 bp
  • T to C, chromosome 9 at 108,607,347 bp
  • A to T, chromosome 9 at 122,978,016 bp
  • G to A, chromosome 10 at 57,524,051 bp
  • G to A, chromosome 10 at 76,599,675 bp
  • A to G, chromosome 10 at 77,959,939 bp
  • T to A, chromosome 11 at 54,489,342 bp
  • A to G, chromosome 11 at 72,262,039 bp
  • A to T, chromosome 11 at 84,964,098 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • C to G, chromosome 12 at 33,051,055 bp
  • T to A, chromosome 12 at 119,262,222 bp
  • A to G, chromosome 13 at 31,807,590 bp
  • A to G, chromosome 13 at 41,185,296 bp
  • T to A, chromosome 14 at 54,408,812 bp
  • A to T, chromosome 15 at 5,031,915 bp
  • G to A, chromosome 15 at 39,754,402 bp
  • C to A, chromosome 16 at 4,974,076 bp
  • T to C, chromosome 16 at 23,465,167 bp
  • A to G, chromosome 17 at 24,641,824 bp
  • C to T, chromosome 17 at 74,412,705 bp
  • T to A, chromosome 18 at 14,570,246 bp
  • A to G, chromosome 18 at 36,992,971 bp
  • G to A, chromosome 19 at 3,944,265 bp
  • G to A, chromosome 19 at 20,702,264 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5562 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043119-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.