Strain Name:
C57BL/6J-MtgxR5582Btlr/Mmmh
Stock Number:
043136-MU
Citation ID:
RRID:MMRRC_043136-MU
Other Names:
R5582 (G1), C57BL/6J-MtgxR5582Btlr
Major Collection:

Gene Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72895
Homologene: 12485
Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319582
Homologene: 35306
Ptx3
Name: pentraxin related gene
Synonyms: TSG-14, pentraxin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19288
HGNC: HGNC:9692
Homologene: 7500
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Sfrs16, Srsf16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53609
Homologene: 134306
Ppp1r37
Name: protein phosphatase 1, regulatory subunit 37
Synonyms: Lrrc68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232947
Homologene: 17851
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224807
Homologene: 101682
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70508
Homologene: 10634
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, 4933439E17Rik, 4930513H15Rik, D14Ertd581e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107182
Homologene: 31978
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: 4930554K12Rik, D130072O21Rik, tankyrase 1, TANK1, mTNKS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21951
Homologene: 18405
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22222
Homologene: 7582
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22763
Homologene: 8009
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Chek2
Name: checkpoint kinase 2
Synonyms: CHK2, Rad53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50883
Homologene: 38289
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Txnrd1
Name: thioredoxin reductase 1
Synonyms: TrxR1, TR1, TR alpha, TR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50493
VEGA: 10
Homologene: 55733
Tsn
Name: translin
Synonyms: TB-RBP, 2610034C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22099
Homologene: 3397
Clic6
Name: chloride intracellular channel 6
Synonyms: CLIC1L, 5730466J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209195
HGNC: HGNC:2065
Homologene: 43154
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
H3f3a
Name: H3.3 histone A
Synonyms: H3.3A, H3-3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15078
Homologene: 134170
Fosl1
Name: fos-like antigen 1
Synonyms: fra-1, Fra1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14283
VEGA: 19
Homologene: 3967
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 386750
Homologene: 8955
Hs1bp3
Name: HCLS1 binding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58240
VEGA: 12
Homologene: 10980
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 279499
Homologene: 18630
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: FATP2, VLCS, FATP2, Vlacs, Vlac, ACSVL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26458
Homologene: 37830
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218865
Homologene: 41261
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52864
Homologene: 23770
Vmn1r69
Name: vomeronasal 1 receptor 69
Synonyms: V1re9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252904
Homologene: 120153
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20274
Homologene: 2237
Gm10130
Name: predicted gene 10130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 102633750
VEGA: 2
Entpd7
Name: ectonucleoside triphosphate diphosphohydrolase 7
Synonyms: LALP1, 2810003F23Rik, 1810020C02Rik, Lysal2, 1810012B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93685
Homologene: 122202
Arid5a
Name: AT rich interactive domain 5A (MRF1-like)
Synonyms: Mrf1, D430024K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214855
Homologene: 34940
Plbd2
Name: phospholipase B domain containing 2
Synonyms: 66.3 kDa, p76, 1300012G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71772
Homologene: 41528
Olfr340
Name: olfactory receptor 340
Synonyms: GA_x6K02T2NLDC-33147742-33148680, MOR136-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258953
Homologene: 74159
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: IsoT-3, ISOT3, 2700071E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72607
Homologene: 68372
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76645
Homologene: 124481
Agxt2
Name: alanine-glyoxylate aminotransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268782
Homologene: 12887
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Sipa1
Name: signal-induced proliferation associated gene 1
Synonyms: SPA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20469
VEGA: 19
Homologene: 7940
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240843
Homologene: 10905
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
Prr14
Name: proline rich 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233895
Homologene: 11424
Zfp780b
Name: zinc finger protein 780B
Synonyms: B230208L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338354
Homologene: 85969
Sgcg
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms: gamma-SG, 5430420E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24053
Homologene: 194
Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Synonyms: 2700007F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72535
HGNC: HGNC:407
Homologene: 115470
Olfr748
Name: olfactory receptor 748
Synonyms: GA_x6K02T2PMLR-6454789-6455712, MOR106-9P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258113
Homologene: 134081
Ppt2
Name: palmitoyl-protein thioesterase 2
Synonyms: 0610007M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54397
HGNC: HGNC:9326
Homologene: 10448
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66971
Homologene: 9502
Lsmem1
Name: leucine-rich single-pass membrane protein 1
Synonyms: LOC380755, Gm889
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380755
VEGA: 12
Homologene: 18800
Otop3
Name: otopetrin 3
Synonyms: 2310011E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69602
Homologene: 26091
Igkv3-7
Name: immunoglobulin kappa variable 3-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108005
Gm6124
Name: predicted gene 6124
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620018
Homologene: 45597
Gm15841
Name: predicted gene 15841
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Mir7684
Name: microRNA 7684
Synonyms: mmu-mir-7684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102465786
VEGA: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,318,122 bp
  • G to A, chromosome 1 at 74,907,518 bp
  • A to T, chromosome 1 at 93,282,361 bp
  • G to A, chromosome 1 at 118,305,214 bp
  • T to C, chromosome 1 at 158,249,409 bp
  • A to T, chromosome 1 at 180,810,085 bp
  • T to C, chromosome 2 at 36,453,221 bp
  • A to T, chromosome 2 at 66,565,029 bp
  • T to C, chromosome 2 at 120,915,407 bp
  • C to T, chromosome 2 at 126,564,690 bp
  • T to C, chromosome 2 at 150,363,052 bp
  • T to A, chromosome 2 at 154,345,974 bp
  • T to C, chromosome 3 at 32,911,589 bp
  • C to T, chromosome 3 at 66,221,005 bp
  • G to T, chromosome 3 at 73,050,404 bp
  • T to C, chromosome 3 at 126,946,305 bp
  • G to T, chromosome 4 at 45,802,750 bp
  • T to C, chromosome 5 at 110,868,035 bp
  • T to C, chromosome 5 at 120,493,106 bp
  • A to G, chromosome 6 at 70,608,006 bp
  • T to C, chromosome 6 at 113,114,925 bp
  • A to G, chromosome 7 at 10,580,508 bp
  • A to G, chromosome 7 at 19,532,294 bp
  • A to C, chromosome 7 at 19,586,856 bp
  • T to A, chromosome 7 at 27,964,827 bp
  • A to G, chromosome 7 at 39,220,198 bp
  • T to C, chromosome 7 at 49,452,778 bp
  • CCAGGGC to CC, chromosome 7 at 80,098,339 bp
  • A to T, chromosome 7 at 127,476,397 bp
  • G to A, chromosome 8 at 34,940,861 bp
  • T to C, chromosome 8 at 36,512,321 bp
  • G to A, chromosome 8 at 105,408,443 bp
  • A to T, chromosome 8 at 117,040,783 bp
  • T to A, chromosome 9 at 80,089,876 bp
  • T to A, chromosome 10 at 82,895,980 bp
  • A to C, chromosome 11 at 9,636,639 bp
  • T to C, chromosome 11 at 59,099,976 bp
  • T to A, chromosome 11 at 115,339,339 bp
  • A to G, chromosome 12 at 8,010,788 bp
  • AGAGGAGGAGGAGGAGGAGGAGGAGGAGG to AGAGGAGGAGGAGGAGGAGGAGGAGG, chromosome 12 at 8,324,048 bp
  • A to G, chromosome 12 at 40,180,644 bp
  • A to G, chromosome 14 at 30,036,859 bp
  • T to C, chromosome 14 at 50,710,968 bp
  • T to C, chromosome 14 at 61,225,305 bp
  • C to T, chromosome 14 at 65,028,896 bp
  • C to T, chromosome 14 at 99,137,130 bp
  • T to C, chromosome 14 at 103,583,139 bp
  • A to G, chromosome 15 at 10,399,159 bp
  • A to G, chromosome 15 at 12,184,090 bp
  • C to T, chromosome 15 at 66,693,435 bp
  • A to T, chromosome 15 at 82,392,118 bp
  • T to C, chromosome 16 at 3,985,788 bp
  • A to G, chromosome 16 at 50,223,356 bp
  • A to T, chromosome 16 at 92,499,454 bp
  • G to A, chromosome 17 at 34,617,399 bp
  • C to A, chromosome 17 at 45,667,763 bp
  • T to C, chromosome 19 at 5,455,267 bp
  • C to T, chromosome 19 at 5,654,701 bp
  • T to C, chromosome 19 at 36,988,173 bp
  • T to C, chromosome 19 at 43,704,994 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5582 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043136-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.