Strain Name:
C57BL/6J-MtgxR5592Btlr/Mmmh
Stock Number:
043144-MU
Citation ID:
RRID:MMRRC_043144-MU
Other Names:
R5592 (G1), C57BL/6J-MtgxR5592Btlr
Major Collection:

Gene Information

Drd1
Name: dopamine receptor D1
Synonyms: Drd-1, C030036C15Rik, D1 receptor, Drd1a, Gpcr15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13488
VEGA: 13
HGNC: HGNC:3020
Homologene: 30992
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, alphaII-spectrin, Spna2, Spna-2, 2610027H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218693
Homologene: 4709
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218613
Homologene: 18196
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: 2210403E04Rik, d1401, 2210412K19Rik, alpha-ketoglutarate dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Adcy1
Name: adenylate cyclase 1
Synonyms: D11Bwg1392e, AC1, I-AC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: NCU-G1, 0610031J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56700
Homologene: 10562
Rb1
Name: RB transcriptional corepressor 1
Synonyms: Rb-1, pRb, Rb, retinoblastoma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Crmp1
Name: collapsin response mediator protein 1
Synonyms: Ulip3, DRP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: CD156b, Tace
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Ubqln4
Name: ubiquilin 4
Synonyms: UBIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94232
HGNC: HGNC:1237
Homologene: 41346
Prrg4
Name: proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
Synonyms: TMG4, 9930111I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228413
Homologene: 11451
Glt1d1
Name: glycosyltransferase 1 domain containing 1
Synonyms: 5730455A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319804
Homologene: 16965
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Gm7102
Name: predicted gene 7102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 633057
Muc19
Name: mucin 19
Synonyms: sld, apomucin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239611
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22324
Homologene: 3961
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232854
Homologene: 119890
Olfr651
Name: olfactory receptor 651
Synonyms: MOR31-11, GA_x6K02T2PBJ9-7179540-7180481
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258809
Homologene: 64922
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237465
Homologene: 52182
Art3
Name: ADP-ribosyltransferase 3
Synonyms: 4930569O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109979
HGNC: HGNC:725
Homologene: 911
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Synm
Name: synemin, intermediate filament protein
Synonyms: 4930412K21Rik, Synemin, Dmn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233335
Homologene: 9081
Galnt16
Name: polypeptide N-acetylgalactosaminyltransferase 16
Synonyms: 5730405L21Rik, Galntl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 108760
VEGA: 12
Homologene: 18907
Uroc1
Name: urocanase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243537
Homologene: 76629
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: Rdgb2, RDGBA2, NIR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19679
Homologene: 7915
Golgb1
Name: golgi autoantigen, golgin subfamily b, macrogolgin 1
Synonyms: Gm6840, 6330407A06Rik, Giantin, C130074L01Rik, F730017E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC-I, SREC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380713
Homologene: 2741
Slc16a5
Name: solute carrier family 16 (monocarboxylic acid transporters), member 5
Synonyms: A130015N09Rik, MCT5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217316
Homologene: 20985
Myo1a
Name: myosin IA
Synonyms: brush border myosin 1, BBM-I, Myhl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmg1-rs1, Hmgox, T160, Hmgi-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Krt12
Name: keratin 12
Synonyms: Krt1-12, K12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268482
HGNC: HGNC:6414
Homologene: 188
Mlip
Name: muscular LMNA-interacting protein
Synonyms: CIP, cardiac ISL1-interacting protein, 2310046A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69642
Homologene: 90445
A630001G21Rik
Name: RIKEN cDNA A630001G21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319997
Homologene: 79992
Mmp25
Name: matrix metallopeptidase 25
Synonyms: MT6-MMP, Leukolysin, F730048C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240047
VEGA: 17
Homologene: 23375
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: CYSLT2R, Cyslt2, 2300001H05Rik, CysLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
Rpa3
Name: replication protein A3
Synonyms: 14kDa, C330026P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68240
Homologene: 68285
Olfr1157
Name: olfactory receptor 1157
Synonyms: GA_x6K02T2Q125-49446395-49445457, MOR174-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258846
HGNC: HGNC:8350
Homologene: 17402
Gimap4
Name: GTPase, IMAP family member 4
Synonyms: Ian1, E430007K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107526
Homologene: 75084
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: 5430426F17Rik, Cdc91l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228812
Homologene: 6553
Mucl3
Name: mucin like 3
Synonyms: LOC268949, Dpcr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268949
Homologene: 133813
Gm5930
Name: predicted gene 5930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 546250
BE692007
Name: expressed sequence BE692007
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100504727
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 85,726,611 bp
  • C to T, chromosome 2 at 29,986,719 bp
  • T to C, chromosome 2 at 85,045,519 bp
  • A to G, chromosome 2 at 87,962,340 bp
  • T to C, chromosome 2 at 104,832,778 bp
  • A to G, chromosome 2 at 155,299,050 bp
  • T to G, chromosome 3 at 88,326,026 bp
  • T to G, chromosome 3 at 88,556,864 bp
  • A to C, chromosome 5 at 37,265,265 bp
  • T to A, chromosome 5 at 92,392,820 bp
  • T to C, chromosome 5 at 124,142,149 bp
  • A to T, chromosome 5 at 127,657,119 bp
  • A to T, chromosome 6 at 8,257,694 bp
  • A to T, chromosome 6 at 48,691,158 bp
  • A to G, chromosome 6 at 90,355,344 bp
  • G to T, chromosome 7 at 7,181,315 bp
  • A to G, chromosome 7 at 67,759,516 bp
  • A to T, chromosome 7 at 104,553,731 bp
  • G to A, chromosome 9 at 77,230,482 bp
  • C to T, chromosome 10 at 93,550,202 bp
  • G to T, chromosome 10 at 127,714,039 bp
  • A to T, chromosome 11 at 6,316,763 bp
  • A to T, chromosome 11 at 7,139,088 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to G, chromosome 11 at 60,720,399 bp
  • A to T, chromosome 11 at 75,525,687 bp
  • C to T, chromosome 11 at 99,420,824 bp
  • A to G, chromosome 11 at 115,472,782 bp
  • A to G, chromosome 11 at 117,760,497 bp
  • C to T, chromosome 12 at 21,334,137 bp
  • T to C, chromosome 12 at 80,588,519 bp
  • T to G, chromosome 13 at 13,743,333 bp
  • A to T, chromosome 13 at 54,054,171 bp
  • T to A, chromosome 13 at 111,706,661 bp
  • C to A, chromosome 13 at 119,450,798 bp
  • C to T, chromosome 14 at 44,331,429 bp
  • T to C, chromosome 14 at 73,029,491 bp
  • A to G, chromosome 14 at 73,211,747 bp
  • C to A, chromosome 14 at 103,194,677 bp
  • T to C, chromosome 15 at 91,930,314 bp
  • T to A, chromosome 16 at 36,925,763 bp
  • A to G, chromosome 17 at 23,640,202 bp
  • T to C, chromosome 17 at 35,643,643 bp
  • G to A, chromosome 17 at 46,520,591 bp
  • A to G, chromosome 17 at 57,304,835 bp
  • A to T, chromosome 17 at 67,858,272 bp
  • A to G, chromosome 19 at 11,480,277 bp
  • A to G, chromosome 19 at 11,481,132 bp
  • G to A, chromosome 19 at 16,725,571 bp
  • T to A, chromosome 19 at 47,102,725 bp
  • C to T, chromosome 19 at 61,175,926 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5592 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043144-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.