Strain Name:
C57BL/6J-MtgxR5595Btlr/Mmmh
Stock Number:
043147-MU
Citation ID:
RRID:MMRRC_043147-MU
Other Names:
R5595 (G1), C57BL/6J-MtgxR5595Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rock-II, B230113H15Rik, Rho-kinase, ROKalpha, Rock2m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19878
VEGA: 12
Homologene: 21010
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Cop1, Rfwd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26374
Homologene: 115565
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22323
Homologene: 7592
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, HELIC2, A330064G03Rik, Ascc3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320632
Homologene: 5859
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, Fgfr-3, sam3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Htt
Name: huntingtin
Synonyms: huntingtin, HD, htt, IT15, C430023I11Rik, Hdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Arhgef2
Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Synonyms: Lfc, GEF-H1, LFP40, GEFH1, P40, Lbcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Cdc37
Name: cell division cycle 37
Synonyms: p50Cdc37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12539
VEGA: 9
HGNC: HGNC:1735
Homologene: 38268
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, 0910001L17Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320011
Homologene: 10586
Ctnnd2
Name: catenin (cadherin associated protein), delta 2
Synonyms: Nprap, Catnd2, neurojugin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Btbd16
Name: BTB (POZ) domain containing 16
Synonyms: E330040A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330660
Homologene: 77327
Eif4e1b
Name: eukaryotic translation initiation factor 4E family member 1B
Synonyms: Eif4eloo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218268
Homologene: 100945
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC269160, LOC381317, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
4931406B18Rik
Name: RIKEN cDNA 4931406B18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74054
Homologene: 105741
Klk1
Name: kallikrein 1
Synonyms: mGk-6, 0610007D04Rik, Klk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16612
Homologene: 68141
Nckap1l
Name: NCK associated protein 1 like
Synonyms: 4930568P13Rik, Hem1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233231
Homologene: 24986
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269514
Homologene: 8128
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 104002
Homologene: 122226
Cryz
Name: crystallin, zeta
Synonyms: quinone reductase, Sez9, SEZ9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12972
HGNC: HGNC:2419
Homologene: 133907
Otoa
Name: otoancorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246190
Homologene: 71803
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78809
Homologene: 53527
Dpy19l1
Name: dpy-19-like 1 (C. elegans)
Synonyms: 1100001I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244745
Homologene: 14762
Mettl2
Name: methyltransferase like 2
Synonyms: C130031G21Rik, D11Ertd768e, PSENIP1, 2810438F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52686
Homologene: 10174
Ovol2
Name: ovo like zinc finger 2
Synonyms: M-OVO-B, M-OVO-A, M-OVO, 1810007D21Rik, Ovol2, Zfp339, movo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107586
Homologene: 10930
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225638
Homologene: 50475
Taar4
Name: trace amine-associated receptor 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209513
Homologene: 45509
Fbxo41
Name: F-box protein 41
Synonyms: D6Ertd538e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330369
Homologene: 19837
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700111D19Rik, 4930445I03Rik, 1700001O02Rik, 1700041C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73332
Homologene: 137391
Plek2
Name: pleckstrin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27260
Homologene: 8447
Rhbdl3
Name: rhomboid like 3
Synonyms: Ventrhoid, Vrho, Rhbdl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246104
Homologene: 34700
Akt1
Name: thymoma viral proto-oncogene 1
Synonyms: PKB/Akt, PKBalpha, Akt, PKB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11651
HGNC: HGNC:391
Homologene: 3785
Micu2
Name: mitochondrial calcium uptake 2
Synonyms: 4833427E09Rik, 1110008L20Rik, Efha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68514
VEGA: 14
Homologene: 12516
Tec
Name: tec protein tyrosine kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21682
Homologene: 1302
Olfr605
Name: olfactory receptor 605
Synonyms: GA_x6K02T2PBJ9-6164792-6163848, MOR202-22P, MOR24-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258156
Homologene: 79414
Phyhip
Name: phytanoyl-CoA hydroxylase interacting protein
Synonyms: PAHX-AP#1, PAHX-AP1, C630010D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105653
Homologene: 8847
Olfr689
Name: olfactory receptor 689
Synonyms: GA_x6K02T2PBJ9-7942985-7943947, MOR40-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258745
Homologene: 128074
Meox1
Name: mesenchyme homeobox 1
Synonyms: Mox-1, Mox1, D330041M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17285
HGNC: HGNC:7013
Homologene: 3326
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56388
Homologene: 135775
BC048403
Name: cDNA sequence BC048403
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 270802
Homologene: 17580
Tdpoz4
Name: TD and POZ domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 399675
Homologene: 130121
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329154
Homologene: 27547
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Fem1al
Name: fem-1 homolog A like
Synonyms: 4931440F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216622
Vmn1r89
Name: vomeronasal 1 receptor 89
Synonyms: V1rj2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171260
Homologene: 74345
Teddm2
Name: transmembrane epididymal family member 2
Synonyms: e9-2, 5830403L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240817
Homologene: 65346
Crtac1
Name: cartilage acidic protein 1
Synonyms: 2810454P21Rik, Crtac1B, Lotus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72832
VEGA: 19
Homologene: 23070
9930111J21Rik2
Name: RIKEN cDNA 9930111J21 gene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245240
Zfp213
Name: zinc finger protein 213
Synonyms: D17Ertd197e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 449521
VEGA: 17
Homologene: 55809
Gm3962
Name: predicted gene 3962
Synonyms: Gm4033
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042681
Gm13760
Name: predicted gene 13760
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,150,226 bp
  • A to T, chromosome 1 at 54,735,050 bp
  • T to C, chromosome 1 at 54,762,347 bp
  • A to T, chromosome 1 at 82,289,925 bp
  • T to C, chromosome 1 at 153,850,400 bp
  • T to A, chromosome 1 at 159,250,073 bp
  • T to C, chromosome 1 at 188,906,498 bp
  • C to T, chromosome 2 at 65,460,713 bp
  • A to T, chromosome 2 at 88,756,405 bp
  • T to C, chromosome 2 at 127,226,013 bp
  • A to G, chromosome 2 at 144,331,184 bp
  • A to T, chromosome 3 at 64,126,615 bp
  • A to G, chromosome 3 at 88,642,976 bp
  • A to T, chromosome 3 at 93,797,499 bp
  • T to A, chromosome 3 at 154,606,518 bp
  • T to C, chromosome 4 at 22,433,641 bp
  • T to C, chromosome 4 at 119,323,946 bp
  • G to A, chromosome 5 at 33,730,003 bp
  • T to A, chromosome 5 at 34,905,397 bp
  • T to A, chromosome 5 at 72,768,744 bp
  • A to C, chromosome 5 at 145,994,863 bp
  • A to G, chromosome 6 at 42,364,634 bp
  • G to A, chromosome 6 at 85,479,901 bp
  • A to T, chromosome 7 at 8,739,654 bp
  • A to T, chromosome 7 at 13,219,930 bp
  • A to G, chromosome 7 at 19,257,891 bp
  • A to G, chromosome 7 at 43,497,872 bp
  • T to C, chromosome 7 at 44,228,737 bp
  • A to T, chromosome 7 at 48,447,684 bp
  • A to T, chromosome 7 at 103,442,428 bp
  • A to T, chromosome 7 at 105,314,006 bp
  • T to A, chromosome 7 at 121,121,977 bp
  • G to A, chromosome 7 at 130,823,303 bp
  • C to A, chromosome 7 at 130,823,304 bp
  • G to C, chromosome 7 at 131,054,067 bp
  • A to T, chromosome 8 at 109,655,520 bp
  • A to T, chromosome 8 at 122,894,304 bp
  • G to A, chromosome 9 at 21,143,213 bp
  • A to T, chromosome 9 at 24,423,203 bp
  • C to T, chromosome 10 at 12,682,318 bp
  • G to A, chromosome 10 at 23,960,741 bp
  • T to C, chromosome 10 at 121,740,147 bp
  • T to C, chromosome 11 at 29,824,288 bp
  • C to T, chromosome 11 at 49,019,711 bp
  • T to C, chromosome 11 at 80,337,583 bp
  • T to C, chromosome 11 at 101,879,343 bp
  • T to A, chromosome 11 at 105,138,647 bp
  • T to A, chromosome 12 at 16,942,809 bp
  • T to A, chromosome 12 at 78,894,109 bp
  • A to T, chromosome 12 at 112,658,616 bp
  • G to A, chromosome 13 at 54,786,716 bp
  • C to A, chromosome 13 at 61,037,060 bp
  • G to A, chromosome 14 at 57,971,744 bp
  • A to T, chromosome 14 at 70,466,874 bp
  • C to T, chromosome 15 at 30,669,543 bp
  • A to G, chromosome 15 at 95,094,884 bp
  • T to C, chromosome 15 at 98,850,024 bp
  • T to A, chromosome 15 at 103,475,658 bp
  • T to C, chromosome 16 at 4,864,279 bp
  • A to G, chromosome 17 at 23,561,186 bp
  • T to A, chromosome 17 at 57,262,460 bp
  • A to T, chromosome 18 at 65,266,248 bp
  • C to T, chromosome 19 at 42,413,951 bp
  • A to G, chromosome 19 at 43,465,157 bp
  • T to C, chromosome 19 at 46,284,422 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5595 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043147-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.