Strain Name:
C57BL/6J-MtgxR5597Btlr/Mmmh
Stock Number:
043149-MU
Citation ID:
RRID:MMRRC_043149-MU
Other Names:
R5597 (G1), C57BL/6J-MtgxR5597Btlr
Major Collection:

Gene Information

Olig2
Name: oligodendrocyte transcription factor 2
Synonyms: RK17, bHLHe19, Bhlhb1, Olg-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50913
HGNC: HGNC:9398
Homologene: 4241
Pdzk1ip1
Name: PDZK1 interacting protein 1
Synonyms: Map17, 0610007F13Rik, 2700030M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67182
Homologene: 4213
Prss12
Name: protease, serine 12 neurotrypsin (motopsin)
Synonyms: motopsin, Bssp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Egf
Name: epidermal growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Dst
Name: dystonin
Synonyms: Bpag1, Bpag, 2310001O04Rik, nmf339, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, bullous pemphigoid antigen 1, athetoid, A830042E19Rik, ah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20321
Homologene: 40653
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Acf7, Aclp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: PDZ-RGS3, RGS3S, 4930506N09Rik, C2pa, C2PA-RGS3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100929
Homologene: 7068
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Lars2
Name: leucyl-tRNA synthetase, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102436
VEGA: 9
Homologene: 6526
Cdca8
Name: cell division cycle associated 8
Synonyms: 4831429J16Rik, Borealin, DasraB, D4Ertd421e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52276
Homologene: 23075
St7
Name: suppression of tumorigenicity 7
Synonyms: TSG7, 9430001H04Rik, Fam4a2, HELG, RAY1, SEN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Btla
Name: B and T lymphocyte associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208154
Homologene: 52233
Lamc1
Name: laminin, gamma 1
Synonyms: laminin B2, Lamb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l(7)-3Rn, Doc4, Odz4, ELM2, l7Rn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Yy1
Name: YY1 transcription factor
Synonyms: Yin Yang 1, delta transcription factor, UCRBP transcription factor, NF-E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22632
Homologene: 2556
Prkag1
Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Synonyms: Prkaac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19082
VEGA: 15
HGNC: HGNC:9385
Homologene: 99712
Hp1bp3
Name: heterochromatin protein 1, binding protein 3
Synonyms: Hp1bp74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15441
Homologene: 7774
Smad4
Name: SMAD family member 4
Synonyms: DPC4, Madh4, D18Wsu70e, Smad 4, Dpc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17128
HGNC: HGNC:6770
Homologene: 31310
Pwwp2a
Name: PWWP domain containing 2A
Synonyms: 4631424J17Rik, D930040F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70802
Homologene: 19687
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Swsap1
Name: SWIM type zinc finger 7 associated protein 1
Synonyms: 2310047B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66962
VEGA: 9
Homologene: 18487
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: OATP-D, Slc21a11, MJAM, Anr1, 5830414C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108116
Homologene: 40862
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Irf6
Name: interferon regulatory factor 6
Synonyms: E230028I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54139
HGNC: HGNC:6121
Homologene: 4479
Nebl
Name: nebulette
Synonyms: A630080F05Rik, Lnebl, 1200007O21Rik, D830029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74103
Homologene: 128431
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Palmd
Name: palmdelphin
Synonyms: 4631423C22Rik, PALML
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114301
Homologene: 9804
Slc30a10
Name: solute carrier family 30, member 10
Synonyms: E130106K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226781
VEGA: 1
Homologene: 100946
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: [a]1 (XVI) collagen, A530052M23Rik, 2700007F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Zfp11
Name: zinc finger protein 11
Synonyms: Zfp-11, Krox-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22648
Homologene: 87241
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: D830019J24Rik, Cark
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 435766
Homologene: 41084
Ctsk
Name: cathepsin K
Synonyms: Cat K, catK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13038
HGNC: HGNC:2536
Homologene: 68053
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: Vcam-1, CD106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22329
Homologene: 838
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231464
Homologene: 100830
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170833
Homologene: 8332
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: 5330407H02Rik, beta1,6N-acetylglucosaminyltransferase V, 4930471A21Rik, GlcNAc-TV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Nudt7
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 7
Synonyms: 2210404C19Rik, 1300007B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67528
HGNC: HGNC:8054
Homologene: 41564
Aebp1
Name: AE binding protein 1
Synonyms: ACLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11568
HGNC: HGNC:303
Homologene: 878
Tmem225
Name: transmembrane protein 225
Synonyms: 1700030E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75667
VEGA: 9
Homologene: 52854
Olfr807
Name: olfactory receptor 807
Synonyms: GA_x6K02T2PULF-11434134-11433199, MOR117-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258931
Homologene: 27300
Vmn2r126
Name: vomeronasal 2, receptor 126
Synonyms: Gm9268
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668612
Homologene: 104832
Rassf7
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Synonyms: 2400009B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66985
HGNC: HGNC:1166
Homologene: 2595
Dcaf5
Name: DDB1 and CUL4 associated factor 5
Synonyms: BCRP2, 9430020B07Rik, Wdr22, BCRG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320808
VEGA: 12
Homologene: 18564
Gimap4
Name: GTPase, IMAP family member 4
Synonyms: E430007K16Rik, Ian1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107526
Homologene: 75084
Trem2
Name: triggering receptor expressed on myeloid cells 2
Synonyms: Trem2c, Trem2a, Trem2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 83433
Homologene: 10352
Olfr192
Name: olfactory receptor 192
Synonyms: MOR183-11_p, GA_x54KRFPKG5P-55327126-55326203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 404309
Homologene: 131129
Gm13991
Name: predicted gene 13991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433464
Olfr1018
Name: olfactory receptor 1018
Synonyms: MOR260-5, GA_x6K02T2Q125-47301584-47302519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258579
Homologene: 27216
Igkv4-56
Name: immunoglobulin kappa chain variable 4-56
Synonyms: Gm16992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 619743
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,192,713 bp
  • A to T, chromosome 1 at 53,534,452 bp
  • A to G, chromosome 1 at 127,397,566 bp
  • T to C, chromosome 1 at 150,395,239 bp
  • A to G, chromosome 1 at 153,251,970 bp
  • C to A, chromosome 1 at 185,462,700 bp
  • T to A, chromosome 1 at 193,169,326 bp
  • A to G, chromosome 2 at 17,378,167 bp
  • T to C, chromosome 2 at 85,823,460 bp
  • G to A, chromosome 2 at 116,528,153 bp
  • A to T, chromosome 3 at 55,647,462 bp
  • T to C, chromosome 3 at 95,501,696 bp
  • T to A, chromosome 3 at 116,126,002 bp
  • C to T, chromosome 3 at 116,878,238 bp
  • T to A, chromosome 3 at 116,923,576 bp
  • C to T, chromosome 3 at 123,464,740 bp
  • A to G, chromosome 3 at 129,735,974 bp
  • A to T, chromosome 3 at 154,872,128 bp
  • A to T, chromosome 4 at 62,623,845 bp
  • A to G, chromosome 4 at 115,093,492 bp
  • A to T, chromosome 4 at 123,539,777 bp
  • G to A, chromosome 4 at 124,919,000 bp
  • A to G, chromosome 4 at 130,058,304 bp
  • A to T, chromosome 4 at 138,221,628 bp
  • T to C, chromosome 5 at 96,131,119 bp
  • A to T, chromosome 5 at 129,657,102 bp
  • C to T, chromosome 5 at 130,274,657 bp
  • T to C, chromosome 6 at 17,934,228 bp
  • T to C, chromosome 6 at 48,690,764 bp
  • T to A, chromosome 6 at 69,587,483 bp
  • A to G, chromosome 7 at 43,024,649 bp
  • C to A, chromosome 7 at 74,284,462 bp
  • T to A, chromosome 7 at 96,553,517 bp
  • A to G, chromosome 7 at 141,217,111 bp
  • A to G, chromosome 8 at 84,994,028 bp
  • A to T, chromosome 8 at 114,151,766 bp
  • G to T, chromosome 9 at 21,955,946 bp
  • A to G, chromosome 9 at 40,149,430 bp
  • A to T, chromosome 9 at 108,114,932 bp
  • A to T, chromosome 9 at 123,454,982 bp
  • T to C, chromosome 10 at 129,754,886 bp
  • T to C, chromosome 11 at 5,866,487 bp
  • T to C, chromosome 11 at 43,682,595 bp
  • C to T, chromosome 11 at 69,406,074 bp
  • G to A, chromosome 11 at 110,036,537 bp
  • G to T, chromosome 12 at 80,340,043 bp
  • A to G, chromosome 12 at 108,815,510 bp
  • A to G, chromosome 15 at 98,815,908 bp
  • T to A, chromosome 16 at 4,953,929 bp
  • A to G, chromosome 16 at 45,244,236 bp
  • A to T, chromosome 16 at 59,098,347 bp
  • A to T, chromosome 16 at 91,226,880 bp
  • T to C, chromosome 17 at 46,502,665 bp
  • G to A, chromosome 17 at 48,351,812 bp
  • T to C, chromosome 17 at 87,723,361 bp
  • A to C, chromosome 18 at 73,662,827 bp
  • T to A, chromosome 18 at 73,937,270 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5597 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043149-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.