Strain Name:
C57BL/6J-MtgxR5600Btlr/Mmmh
Stock Number:
043152-MU
Citation ID:
RRID:MMRRC_043152-MU
Other Names:
R5600 (G1), C57BL/6J-MtgxR5600Btlr
Major Collection:

Gene Information

Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: EG406236, Hsn2, 6430573H23Rik, Prkwnk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232341
Homologene: 14253
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330953
VEGA: 9
Homologene: 3997
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, Frap1, RAPT1, RAFT1, mechanistic target of rapamycin (serine/threonine kinase), flat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Ktn1
Name: kinectin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16709
HGNC: HGNC:6467
Homologene: 7397
Sfswap
Name: splicing factor SWAP
Synonyms: Sfrs8, 6330437E22Rik, 1190005N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231769
Homologene: 134548
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233789
Homologene: 56697
Pptc7
Name: PTC7 protein phosphatase homolog
Synonyms: 9130017A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320717
Homologene: 6100
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20846
Homologene: 21428
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: Vps34, 5330434F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 21844
Homologene: 2443
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, 2610040L17Rik, Ten-m2, Odz2, 9330187F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23964
Homologene: 22672
Golga1
Name: golgi autoantigen, golgin subfamily a, 1
Synonyms: awag, golgin-97, 0710001G09Rik, 2210418B03Rik, Golgi97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Atp6v1c1
Name: ATPase, H+ transporting, lysosomal V1 subunit C1
Synonyms: 1700025B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66335
VEGA: 15
HGNC: HGNC:856
Homologene: 1281
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: CP110, 6330503K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101565
Homologene: 8810
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Ptgfrn
Name: prostaglandin F2 receptor negative regulator
Synonyms: 4833445A08Rik, CD9P-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19221
HGNC: HGNC:9601
Homologene: 7908
Magel2
Name: melanoma antigen, family L, 2
Synonyms: Mage-l2, NDNL1, nM15, ns7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Fgfrl1
Name: fibroblast growth factor receptor-like 1
Synonyms: FGFR5, FGFR5beta, fibroblast growth factor receptor 5, FGFR5gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 116701
HGNC: HGNC:3693
Homologene: 11067
Mrps18a
Name: mitochondrial ribosomal protein S18A
Synonyms: 1110004O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68565
Homologene: 32391
Sbk1
Name: SH3-binding kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 104175
Homologene: 17084
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: PARIS-1, PARIS1, A630005A06Rik, LOC381605
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381605
Homologene: 10190
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 72432
Homologene: 4987
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Sn, Siglec-1, CD169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20612
Homologene: 124458
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22635
Homologene: 124417
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: 0610027A18Rik, Papd1, Tent6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 67440
VEGA: 18
Homologene: 10008
Olfr118
Name: olfactory receptor 118
Synonyms: MOR263-13, GA_x6K02T2PSCP-2131124-2132089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 404308
Homologene: 110622
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 670940
Homologene: 115466
Krt86
Name: keratin 86
Synonyms: Krt2-10, MHb4, Krt2-11, Khb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16679
VEGA: 15
HGNC: HGNC:6463
Homologene: 1717
Rfx6
Name: regulatory factor X, 6
Synonyms: Rfxdc1, 4930572O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320995
Homologene: 18318
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241263
Homologene: 19381
Wdr66
Name: WD repeat domain 66
Synonyms: 4930415N18Rik, 4933428F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269701
Homologene: 16964
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, Lrrn6d, LERN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 320747
Homologene: 18563
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233328
Homologene: 23464
Zfp108
Name: zinc finger protein 108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54678
Homologene: 117959
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Asprv1
Name: aspartic peptidase, retroviral-like 1
Synonyms: 2300003P22Rik, SASPase, SASP, Taps, TPA-induced aspartic proteinase-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67855
Homologene: 23582
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627814
Homologene: 129678
Gm5431
Name: predicted gene 5431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432555
Apol11b
Name: apolipoprotein L 11b
Synonyms: A330102K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 328563
Homologene: 129975
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 52,148,942 bp
  • A to G, chromosome 2 at 21,827,235 bp
  • T to C, chromosome 2 at 39,020,099 bp
  • T to A, chromosome 2 at 131,085,583 bp
  • A to T, chromosome 3 at 94,401,913 bp
  • T to C, chromosome 3 at 101,056,250 bp
  • T to C, chromosome 4 at 18,011,596 bp
  • C to T, chromosome 4 at 46,629,912 bp
  • G to T, chromosome 4 at 148,491,470 bp
  • T to C, chromosome 5 at 108,705,302 bp
  • T to A, chromosome 5 at 122,320,855 bp
  • T to C, chromosome 5 at 123,288,698 bp
  • T to C, chromosome 5 at 129,513,158 bp
  • C to T, chromosome 5 at 137,386,971 bp
  • G to T, chromosome 6 at 86,629,062 bp
  • A to C, chromosome 6 at 119,949,358 bp
  • A to G, chromosome 7 at 24,260,586 bp
  • G to T, chromosome 7 at 62,379,766 bp
  • A to C, chromosome 7 at 66,307,215 bp
  • G to T, chromosome 7 at 85,563,727 bp
  • A to G, chromosome 7 at 118,167,884 bp
  • G to A, chromosome 7 at 118,729,725 bp
  • G to A, chromosome 7 at 126,292,243 bp
  • T to A, chromosome 9 at 58,859,293 bp
  • A to G, chromosome 9 at 75,289,154 bp
  • A to T, chromosome 10 at 51,723,061 bp
  • C to T, chromosome 11 at 36,163,714 bp
  • G to A, chromosome 11 at 48,894,756 bp
  • T to A, chromosome 11 at 105,333,666 bp
  • A to T, chromosome 14 at 47,690,033 bp
  • T to C, chromosome 15 at 38,686,863 bp
  • A to C, chromosome 15 at 77,635,088 bp
  • G to A, chromosome 15 at 101,476,505 bp
  • G to T, chromosome 16 at 89,865,365 bp
  • C to A, chromosome 17 at 20,540,927 bp
  • G to A, chromosome 17 at 37,672,285 bp
  • T to A, chromosome 17 at 46,125,649 bp
  • A to G, chromosome 18 at 4,379,674 bp
  • G to A, chromosome 18 at 30,311,293 bp
  • A to G, chromosome 18 at 44,018,711 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5600 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043152-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.