Strain Name:
C57BL/6J-MtgxR5638Btlr/Mmmh
Stock Number:
043168-MU
Citation ID:
RRID:MMRRC_043168-MU
Other Names:
R5638 (G1), C57BL/6J-MtgxR5638Btlr
Major Collection:

Strain Information

Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Vps54
Name: VPS54 GARP complex subunit
Synonyms: Vps54l, 5330404P15Rik, mSLP8, wr
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Stip1
Name: stress-induced phosphoprotein 1
Synonyms: p60, IEF SSP 3521, Hop, Hsp70/Hsp90 organizing protein, STI1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20867
VEGA: 19
Homologene: 4965
Igf2bp3
Name: insulin-like growth factor 2 mRNA binding protein 3
Synonyms: 2610101N11Rik, IMP3, Koc13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140488
Homologene: 4773
Rxrb
Name: retinoid X receptor beta
Synonyms: RCoR-1, H-2RIIBP, Nr2b2, Rub
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20182
Homologene: 7923
Cenpa
Name: centromere protein A
Synonyms: centrosomin A, Cenp-A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12615
HGNC: HGNC:1851
Homologene: 1369
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: Zntl1, ZnT-5, ZTL1, 1810010K08Rik, Znt5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Sfrs15, Srsf15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Spag9
Name: sperm associated antigen 9
Synonyms: 4733401I23Rik, syd1, 4831406C20Rik, Mapk8ip4, JIP4, 3110018C07Rik, JLP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Socs2
Name: suppressor of cytokine signaling 2
Synonyms: SOCS-2, cytokine-inducible SH2 protein 2, STAT-induced STAT inhibitor 2, SSI-2, CIS2, JAB, Cish2, D130043N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216233
Homologene: 2880
Ppwd1
Name: peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms: A330090G21Rik, 4632422M10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238831
VEGA: 13
Homologene: 9099
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: antiporter, Apnh, Nhe1, Nhe-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20544
Homologene: 20660
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
2610028H24Rik
Name: RIKEN cDNA 2610028H24 gene
Synonyms: ORF67
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76964
HGNC: HGNC:1300
Homologene: 50540
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212517
Homologene: 75085
Sik1
Name: salt inducible kinase 1
Synonyms: Msk, Snf1lk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17691
VEGA: 17
Homologene: 7847
Or6c210
Name: olfactory receptor family 6 subfamily C member 210
Synonyms: GA_x6K02T2PULF-11338429-11339364, MOR114-7, Olfr800
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258541
Homologene: 27203
Dusp26
Name: dual specificity phosphatase 26
Synonyms: 2310043K02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66959
Homologene: 11421
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70729
Homologene: 135990
A930018M24Rik
Name: RIKEN cDNA A930018M24 gene
Synonyms: LOC382890
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Cep89
Name: centrosomal protein 89
Synonyms: 2610507L03Rik, Ccdc123
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72140
Homologene: 12444
Psd4
Name: pleckstrin and Sec7 domain containing 4
Synonyms: SEC7 homolog, EFA6B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215632
Homologene: 8261
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56527
Homologene: 10543
Skint8
Name: selection and upkeep of intraepithelial T cells 8
Synonyms: OTTMUSG00000009475
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639774
Homologene: 106613
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
1700101I19Rik
Name: RIKEN cDNA 1700101I19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
B3galt1
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
Synonyms: 6330417G03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26877
HGNC: HGNC:916
Homologene: 41362
Ppt2
Name: palmitoyl-protein thioesterase 2
Synonyms: 0610007M19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54397
HGNC: HGNC:9326
Homologene: 10448
Upp2
Name: uridine phosphorylase 2
Synonyms: UDRPASE2, UPASE2, UP2, 1700124F02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76654
Homologene: 12654
Or7g21
Name: olfactory receptor family 7 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-12857805-12858749, MOR152-3, Olfr836
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258557
HGNC: HGNC:8466
Homologene: 115507
Arrb2
Name: arrestin, beta 2
Synonyms: beta arr2, beta-arrestin-2, beta-arrestin2, arrestin 3, Arr3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216869
HGNC: HGNC:712
Homologene: 3183
Mrgpra6
Name: MAS-related GPR, member A6
Synonyms: MrgA6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381886
Alg5
Name: ALG5 dolichyl-phosphate beta-glucosyltransferase
Synonyms: 1500026A19Rik, 2600005J22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66248
Homologene: 7060
Cmtm4
Name: CKLF-like MARVEL transmembrane domain containing 4
Synonyms: Cklfsf4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97487
Homologene: 45211
Kpna2rt
Name: karyopherin subunit alpha 2, retrotransposed
Synonyms: Gm10184
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043906
VEGA: 17
HGNC: HGNC:6395
Gm5493
Name: predicted gene 5493
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433078
G0s2
Name: G0/G1 switch gene 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14373
Homologene: 7326
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,579,412 bp
  • T to G, chromosome 1 at 129,595,533 bp
  • T to A, chromosome 1 at 170,349,399 bp
  • A to G, chromosome 1 at 189,786,841 bp
  • A to T, chromosome 1 at 193,272,551 bp
  • T to C, chromosome 2 at 24,397,415 bp
  • T to C, chromosome 2 at 58,790,095 bp
  • T to C, chromosome 2 at 68,118,751 bp
  • A to G, chromosome 2 at 181,645,588 bp
  • C to T, chromosome 3 at 54,738,833 bp
  • T to A, chromosome 3 at 108,862,892 bp
  • C to A, chromosome 4 at 111,950,193 bp
  • T to A, chromosome 4 at 133,412,260 bp
  • A to T, chromosome 5 at 30,673,392 bp
  • C to T, chromosome 5 at 123,818,475 bp
  • A to G, chromosome 5 at 125,048,300 bp
  • A to G, chromosome 5 at 150,359,081 bp
  • T to C, chromosome 6 at 48,492,891 bp
  • C to A, chromosome 6 at 49,087,800 bp
  • A to G, chromosome 7 at 17,159,935 bp
  • A to G, chromosome 7 at 35,417,712 bp
  • G to T, chromosome 7 at 47,185,909 bp
  • T to C, chromosome 7 at 56,204,416 bp
  • A to T, chromosome 7 at 82,611,750 bp
  • C to T, chromosome 7 at 84,940,839 bp
  • T to C, chromosome 8 at 31,094,141 bp
  • T to C, chromosome 8 at 84,924,084 bp
  • A to T, chromosome 8 at 91,011,450 bp
  • T to C, chromosome 8 at 104,357,724 bp
  • A to T, chromosome 8 at 126,450,686 bp
  • T to A, chromosome 9 at 19,121,380 bp
  • G to A, chromosome 10 at 76,452,895 bp
  • T to C, chromosome 10 at 95,392,883 bp
  • T to A, chromosome 10 at 129,660,100 bp
  • T to C, chromosome 11 at 21,308,799 bp
  • T to G, chromosome 11 at 70,435,591 bp
  • C to A, chromosome 11 at 94,069,012 bp
  • T to A, chromosome 13 at 100,813,872 bp
  • A to G, chromosome 13 at 104,220,398 bp
  • T to C, chromosome 14 at 50,896,957 bp
  • A to G, chromosome 16 at 44,455,531 bp
  • T to C, chromosome 16 at 90,244,310 bp
  • A to G, chromosome 17 at 22,750,092 bp
  • C to T, chromosome 17 at 31,850,828 bp
  • T to C, chromosome 17 at 34,037,407 bp
  • C to A, chromosome 17 at 34,625,849 bp
  • T to C, chromosome 17 at 89,910,207 bp
  • T to C, chromosome 18 at 49,891,626 bp
  • G to A, chromosome 19 at 7,032,515 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5638 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043168-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.