Strain Name:
C57BL/6J-MtgxR5672Btlr/Mmmh
Stock Number:
043174-MU
Citation ID:
RRID:MMRRC_043174-MU
Other Names:
R5672 (G1), C57BL/6J-MtgxR5672Btlr
Major Collection:

Gene Information

Ubn2
Name: ubinuclein 2
Synonyms: 2900060J04Rik, D130059P03Rik, 6030408G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320538
Homologene: 45564
Fam131a
Name: family with sequence similarity 131, member A
Synonyms: 2900046G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78408
Homologene: 82234
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74315
Homologene: 14427
Dido1
Name: death inducer-obliterator 1
Synonyms: D130048F08Rik, 6720461J16Rik, Datf1, DIO-1, dido
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Jhdm1b, Fbxl10, Cxxc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 30841
Homologene: 13069
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67724
Homologene: 41000
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Pten
Name: phosphatase and tensin homolog
Synonyms: A130070J02Rik, B430203M17Rik, 2310035O07Rik, MMAC1, TEP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19211
HGNC: HGNC:9588
Homologene: 265
Ankrd13c
Name: ankyrin repeat domain 13c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433667
Homologene: 41804
Abcf3
Name: ATP-binding cassette, sub-family F (GCN20), member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27406
HGNC: HGNC:72
Homologene: 22784
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, Pmscl2, p2, p3, p4, RRP6, PM-Scl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Pwwp2a
Name: PWWP domain containing 2A
Synonyms: D930040F23Rik, 4631424J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70802
Homologene: 19687
Thoc6
Name: THO complex 6
Synonyms: F830014G06Rik, Wdr58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 386612
Homologene: 11533
Snx27
Name: sorting nexin family member 27
Synonyms: 5730552M22Rik, ESTM47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76742
Homologene: 12797
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: alpha-E1, CD103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Klb
Name: klotho beta
Synonyms: betaKlotho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83379
Homologene: 12820
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: Arhgap14, D130026O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 259302
Homologene: 56686
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Iqcg
Name: IQ motif containing G
Synonyms: G1-374-12, stubby12d, repro1, 2400003L07Rik, esgd12d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69707
Homologene: 32776
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 1810008K04Rik, 2010002N16Rik, 2810455B10Rik, PAR3L, Als2cr19, PAR3beta, PAR3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224582
Homologene: 129678
Efna5
Name: ephrin A5
Synonyms: RAGS, LERK-7, Ephrin-A5, AL-1, Epl7, EFL-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13640
HGNC: HGNC:3225
Homologene: 1482
Olfr1331
Name: olfactory receptor 1331
Synonyms: MOR259-3P, GA_x6K02T2QD9B-18670866-18669913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258159
Homologene: 134082
Smgc
Name: submandibular gland protein C
Synonyms: 2310010P21Rik, Sfc21, DXImx49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223809
Olfr467
Name: olfactory receptor 467
Synonyms: MOR204-33P, GA_x6K02T2PBJ9-10144091-10145011
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257919
Homologene: 81542
Spem1
Name: sperm maturation 1
Synonyms: 1700095G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74288
Homologene: 45717
Serpina1d
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1D
Synonyms: Spi1-4, PI4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20703
HGNC: HGNC:8941
Homologene: 20103
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330222
Homologene: 27395
Ube2ql1
Name: ubiquitin-conjugating enzyme E2Q family-like 1
Synonyms: 3110006E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76980
VEGA: 13
Homologene: 15975
Klc3
Name: kinesin light chain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232943
Homologene: 14899
Nrd1
Name: nardilysin, N-arginine dibasic convertase, NRD convertase 1
Synonyms: NRD-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230598
HGNC: HGNC:7995
Homologene: 68260
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404289
Homologene: 104166
Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms: 1600019A21Rik, SPI-CI, R86, Spi10, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20706
HGNC: HGNC:8955
Homologene: 137240
Cyp2c55
Name: cytochrome P450, family 2, subfamily c, polypeptide 55
Synonyms: 2010318C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72082
HGNC: HGNC:2620
Homologene: 133567
Odr4
Name: odr4 GPCR localization factor homolog
Synonyms: 1810053E15Rik, BC003331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226499
Homologene: 41202
Ldhd
Name: lactate dehydrogenase D
Synonyms: D8Bwg1320e, 4733401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52815
Homologene: 5536
Gm6899
Name: predicted gene 6899
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Olfr58
Name: olfactory receptor 58
Synonyms: MOR146-7P, IG6, GA_x6K02T2PVTD-13523015-13523944, MOR146-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18358
Homologene: 134093
Plat
Name: plasminogen activator, tissue
Synonyms: t-PA, tPA, D8Ertd2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
1110032A03Rik
Name: RIKEN cDNA 1110032A03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68721
HGNC: HGNC:1163
Homologene: 11242
A4gnt
Name: alpha-1,4-N-acetylglucosaminyltransferase
Synonyms: LOC333424, alpha4GnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 333424
Homologene: 87446
Mxd4
Name: Max dimerization protein 4
Synonyms: Mad4, bHLHc12, 2810410A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17122
Homologene: 4712
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 62,010,466 bp
  • A to G, chromosome 1 at 150,382,443 bp
  • T to A, chromosome 2 at 41,341,759 bp
  • A to T, chromosome 2 at 82,987,494 bp
  • A to G, chromosome 2 at 127,804,880 bp
  • A to G, chromosome 2 at 180,671,903 bp
  • A to T, chromosome 3 at 94,502,850 bp
  • T to C, chromosome 3 at 157,961,027 bp
  • A to T, chromosome 4 at 109,038,045 bp
  • A to G, chromosome 4 at 118,869,182 bp
  • A to G, chromosome 4 at 148,582,325 bp
  • G to A, chromosome 5 at 34,177,700 bp
  • T to C, chromosome 5 at 65,379,949 bp
  • T to C, chromosome 5 at 122,988,929 bp
  • T to C, chromosome 5 at 142,188,145 bp
  • T to C, chromosome 6 at 38,461,527 bp
  • T to A, chromosome 6 at 112,775,561 bp
  • T to C, chromosome 7 at 19,396,331 bp
  • A to C, chromosome 7 at 23,984,316 bp
  • A to G, chromosome 7 at 107,814,637 bp
  • T to C, chromosome 8 at 22,773,648 bp
  • A to G, chromosome 8 at 111,630,332 bp
  • T to A, chromosome 9 at 19,783,211 bp
  • T to C, chromosome 9 at 50,763,927 bp
  • A to G, chromosome 9 at 99,620,330 bp
  • C to T, chromosome 11 at 26,593,484 bp
  • C to T, chromosome 11 at 43,706,141 bp
  • G to A, chromosome 11 at 44,531,293 bp
  • T to G, chromosome 11 at 69,821,437 bp
  • T to A, chromosome 11 at 73,145,551 bp
  • A to C, chromosome 12 at 103,763,842 bp
  • A to G, chromosome 13 at 33,039,599 bp
  • G to A, chromosome 13 at 40,280,429 bp
  • A to T, chromosome 13 at 69,739,327 bp
  • A to G, chromosome 15 at 34,530,179 bp
  • G to A, chromosome 15 at 91,841,905 bp
  • T to C, chromosome 16 at 20,162,029 bp
  • A to T, chromosome 16 at 20,549,252 bp
  • G to T, chromosome 16 at 20,699,639 bp
  • C to T, chromosome 16 at 33,019,508 bp
  • A to G, chromosome 17 at 20,596,232 bp
  • A to T, chromosome 17 at 23,669,626 bp
  • A to T, chromosome 17 at 62,881,030 bp
  • A to G, chromosome 19 at 32,758,466 bp
  • A to G, chromosome 19 at 39,035,546 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5672 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043174-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.