Strain Name:
C57BL/6J-MtgxR5684Btlr/Mmmh
Stock Number:
043178-MU
Citation ID:
RRID:MMRRC_043178-MU
Other Names:
R5684 (G1), C57BL/6J-MtgxR5684Btlr
Major Collection:

Gene Information

Slc6a2
Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Synonyms: NE transporter, Slc6a5, norepinephrine transporter, NET
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20538
Homologene: 816
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Smc3
Name: structural maintenance of chromosomes 3
Synonyms: Cspg6, Bamacan, Mmip1, SmcD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 13006
HGNC: HGNC:2468
Homologene: 3974
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208146
VEGA: 16
Homologene: 9967
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 214585
Homologene: 41614
Plec
Name: plectin
Synonyms: Plec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18810
HGNC: HGNC:9069
Homologene: 384
Creb3l1
Name: cAMP responsive element binding protein 3-like 1
Synonyms: Oasis, BBF-2 (drosophila) homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26427
Homologene: 8058
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100317
Homologene: 11764
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Colec12
Name: collectin sub-family member 12
Synonyms: Scara4, SRCL, CL-P1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 140792
VEGA: 18
Homologene: 34248
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77505
Homologene: 131117
Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Synonyms: 5-HT7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 15566
HGNC: HGNC:5302
Homologene: 20244
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22068
VEGA: 9
Homologene: 37944
4933406M09Rik
Name: RIKEN cDNA 4933406M09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240755
Homologene: 128441
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, Cchl1a1, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Zc3hav1
Name: zinc finger CCCH type, antiviral 1
Synonyms: ZAP, 9830115L13Rik, 2900058M19Rik, 9130009D18Rik, 1200014N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78781
Homologene: 10585
Nkpd1
Name: NTPase, KAP family P-loop domain containing 1
Synonyms: 2310015G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69547
Homologene: 18876
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627636
Homologene: 115024
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213556
VEGA: 17
Homologene: 35317
H2-M10.6
Name: histocompatibility 2, M region locus 10.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 399549
Homologene: 117973
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Birc1f, Naip-rs4, Naip-rs4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Bspry
Name: B-box and SPRY domain containing
Synonyms: zetin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 192120
Homologene: 9781
Trmt11
Name: tRNA methyltransferase 11
Synonyms: 3110045I18Rik, 2410075D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 73681
VEGA: 10
Homologene: 6876
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: 6430542K11Rik, Glu5R, Gprc1e, mGluR5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Psg21
Name: pregnancy-specific glycoprotein 21
Synonyms: 1600025N01Rik, 1600026N13Rik, 1600019C01Rik, cea8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72242
Homologene: 110989
Olfr487
Name: olfactory receptor 487
Synonyms: MOR204-31P, GA_x6K02T2PBJ9-10541702-10540758, Olfr1538-ps1, MOR204-31P, MOR204-29P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258042
Homologene: 110483
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230872
Homologene: 16811
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: 1700055P21Rik, Esdn, CLCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 73379
Homologene: 12499
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: Nhe9, 5730527A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 331004
Homologene: 69753
Slc22a15
Name: solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms: A530052I06Rik, 2610034P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242126
Homologene: 41263
Pidd1
Name: p53 induced death domain protein 1
Synonyms: Pidd, Lrdd, 1200011D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57913
Homologene: 11220
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231396
Homologene: 128251
4930519G04Rik
Name: RIKEN cDNA 4930519G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67593
Homologene: 87032
Sorbs3
Name: sorbin and SH3 domain containing 3
Synonyms: SH3P3, Sh3d4, vinexin alpha, vinexin beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 20410
VEGA: 14
Homologene: 4218
Vtn
Name: vitronectin
Synonyms: Vn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22370
Homologene: 532
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: spastic paraplegia 7 homolog (human), paraplegin, Cmar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234847
Homologene: 31133
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: Lppr3, BC005764
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216152
Homologene: 11769
Olfr488
Name: olfactory receptor 488
Synonyms: GA_x6K02T2PBJ9-10586187-10585243, MOR204-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258727
Homologene: 110483
Olfr159
Name: olfactory receptor 159
Synonyms: Olfr37e, mOR37e, GA_x6K02T2N78B-16165641-16166600, MOR262-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 29849
Homologene: 128097
Sfn
Name: stratifin
Synonyms: Ywhas, 14-3-3 sigma, Er, MME1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 55948
Homologene: 4475
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,389,922 bp
  • A to G, chromosome 2 at 91,990,731 bp
  • T to C, chromosome 2 at 122,093,503 bp
  • A to G, chromosome 3 at 101,862,955 bp
  • T to C, chromosome 4 at 43,770,624 bp
  • T to C, chromosome 4 at 62,496,282 bp
  • T to A, chromosome 4 at 116,100,563 bp
  • A to G, chromosome 4 at 126,792,146 bp
  • T to A, chromosome 4 at 133,601,292 bp
  • T to C, chromosome 4 at 141,051,144 bp
  • G to C, chromosome 5 at 87,081,004 bp
  • A to G, chromosome 5 at 108,583,100 bp
  • A to G, chromosome 5 at 114,879,560 bp
  • A to T, chromosome 6 at 38,311,279 bp
  • A to G, chromosome 6 at 118,687,044 bp
  • G to T, chromosome 7 at 18,652,258 bp
  • C to T, chromosome 7 at 19,523,573 bp
  • T to C, chromosome 7 at 88,130,645 bp
  • G to A, chromosome 7 at 105,703,209 bp
  • A to T, chromosome 7 at 108,212,072 bp
  • A to T, chromosome 7 at 108,256,039 bp
  • A to T, chromosome 7 at 141,441,111 bp
  • T to C, chromosome 8 at 80,769,670 bp
  • T to A, chromosome 8 at 92,989,053 bp
  • T to C, chromosome 8 at 123,073,884 bp
  • T to C, chromosome 9 at 8,653,128 bp
  • T to C, chromosome 9 at 95,055,508 bp
  • A to G, chromosome 10 at 30,547,710 bp
  • A to T, chromosome 10 at 79,865,317 bp
  • G to A, chromosome 11 at 78,500,558 bp
  • T to A, chromosome 12 at 75,137,649 bp
  • T to A, chromosome 13 at 100,300,380 bp
  • C to T, chromosome 14 at 70,181,222 bp
  • A to G, chromosome 15 at 76,205,596 bp
  • T to A, chromosome 16 at 13,130,601 bp
  • T to C, chromosome 16 at 20,193,803 bp
  • T to C, chromosome 16 at 58,449,809 bp
  • T to G, chromosome 17 at 19,792,989 bp
  • A to T, chromosome 17 at 36,813,854 bp
  • C to T, chromosome 17 at 84,597,918 bp
  • T to C, chromosome 18 at 9,849,009 bp
  • A to T, chromosome 19 at 16,699,045 bp
  • C to A, chromosome 19 at 35,969,871 bp
  • A to G, chromosome 19 at 53,640,804 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5684 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043178-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.