Strain Name:
C57BL/6J-MtgxR5716Btlr/Mmmh
Stock Number:
043187-MU
Citation ID:
RRID:MMRRC_043187-MU
Other Names:
R5716 (G1), C57BL/6J-MtgxR5716Btlr
Major Collection:

Gene Information

Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109079
Homologene: 56558
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: D030060O14Rik, Rab11-FIP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 215445
Homologene: 49396
Kars
Name: lysyl-tRNA synthetase
Synonyms: LysRS, D8Wsu108e, D8Ertd698e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 85305
HGNC: HGNC:6215
Homologene: 4053
Nuf2
Name: NUF2, NDC80 kinetochore complex component
Synonyms: Nuf2R, 2410003C07Rik, Cdca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66977
Homologene: 40205
Cramp1l
Name: cramped chromatin regulator homolog 1
Synonyms: Tce4, 5830477H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227195
Homologene: 9819
Brf2
Name: BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
Synonyms: 2700059M06Rik, TFIIIB50, 5730512K07Rik, BRFU
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66653
Homologene: 10127
Oser1
Name: oxidative stress responsive serine rich 1
Synonyms: 3230401D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66680
Homologene: 9521
Frmd8
Name: FERM domain containing 8
Synonyms: 4931429L16Rik, 1200004M23Rik, 2310035N23Rik, iTAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67457
Homologene: 32653
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233979
Homologene: 16375
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, E530005C20Rik, LOC224126, Hapip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329650
Homologene: 43143
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: E330028L06Rik, DPD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230613
Homologene: 136292
Gm5546
Name: predicted gene 5546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433634
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71947
Homologene: 8831
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 338350
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Tmem184c
Name: transmembrane protein 184C
Synonyms: Tmem34, 8430433H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234463
Homologene: 32403
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Hexdc
Name: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238023
Homologene: 68120
Olfr767
Name: olfactory receptor 767
Synonyms: GA_x6K02T2PULF-10765431-10764502, MOR115-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258315
Homologene: 105186
Olfr1501
Name: olfactory receptor 1501
Synonyms: GA_x6K02T2RE5P-4171358-4170411, MOR212-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258626
Homologene: 64899
Sytl1
Name: synaptotagmin-like 1
Synonyms: Slp1, PSGL-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269589
Homologene: 12853
Megf11
Name: multiple EGF-like-domains 11
Synonyms: 2410080H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214058
Homologene: 13031
Lcn2
Name: lipocalin 2
Synonyms: neu-related lipocalin, 24p3, NRL, NGAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16819
HGNC: HGNC:6526
Homologene: 4064
Uqcrc1
Name: ubiquinol-cytochrome c reductase core protein 1
Synonyms: 1110032G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22273
Homologene: 2525
Gm9573
Name: predicted gene 9573
Synonyms: Muc21, epiglycanin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 672682
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237353
Homologene: 77551
Gpank1
Name: G patch domain and ankyrin repeats 1
Synonyms: G5, D17H6S54E, Bat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81845
Homologene: 13035
Rassf4
Name: Ras association (RalGDS/AF-6) domain family member 4
Synonyms: 3830411C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213391
Homologene: 12926
Coq8a
Name: coenzyme Q8A
Synonyms: Adck3, Cabc1, 4632432J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67426
Homologene: 11345
Lsmem1
Name: leucine-rich single-pass membrane protein 1
Synonyms: Gm889, LOC380755
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380755
VEGA: 12
Homologene: 18800
Alg1
Name: asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)
Synonyms: HMT1, HMAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208211
Homologene: 5387
Olfr127
Name: olfactory receptor 127
Synonyms: MOR218-7, GA_x6K02T2PSCP-2354126-2355093
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258374
Homologene: 134080
Tpt1
Name: tumor protein, translationally-controlled 1
Synonyms: TCTP, fortilin, Trt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22070
Homologene: 55730
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 63,058,697 bp
  • C to A, chromosome 1 at 169,522,389 bp
  • A to T, chromosome 1 at 180,179,260 bp
  • T to C, chromosome 2 at 4,884,578 bp
  • G to A, chromosome 2 at 31,336,567 bp
  • A to G, chromosome 2 at 31,458,738 bp
  • A to G, chromosome 2 at 32,385,813 bp
  • T to A, chromosome 2 at 52,210,584 bp
  • C to T, chromosome 2 at 163,411,560 bp
  • T to C, chromosome 3 at 59,301,377 bp
  • C to A, chromosome 3 at 76,588,908 bp
  • T to A, chromosome 3 at 104,353,005 bp
  • C to G, chromosome 3 at 104,353,007 bp
  • G to T, chromosome 3 at 118,899,179 bp
  • A to G, chromosome 3 at 122,512,915 bp
  • A to G, chromosome 4 at 112,711,647 bp
  • G to A, chromosome 4 at 133,256,053 bp
  • T to C, chromosome 5 at 73,100,465 bp
  • A to G, chromosome 5 at 121,609,983 bp
  • C to T, chromosome 5 at 150,370,221 bp
  • T to A, chromosome 6 at 12,343,148 bp
  • A to G, chromosome 6 at 116,661,867 bp
  • GGCCAGC to G, chromosome 7 at 80,098,349 bp
  • G to A, chromosome 7 at 120,246,994 bp
  • A to C, chromosome 7 at 145,257,813 bp
  • A to G, chromosome 8 at 27,126,046 bp
  • T to C, chromosome 8 at 77,606,407 bp
  • T to A, chromosome 8 at 112,003,442 bp
  • T to C, chromosome 9 at 64,506,110 bp
  • A to G, chromosome 9 at 108,947,405 bp
  • C to T, chromosome 10 at 59,131,283 bp
  • T to A, chromosome 10 at 129,079,555 bp
  • T to C, chromosome 11 at 115,792,428 bp
  • A to G, chromosome 11 at 121,221,562 bp
  • A to T, chromosome 12 at 40,180,693 bp
  • A to G, chromosome 12 at 59,071,872 bp
  • A to G, chromosome 14 at 75,846,730 bp
  • T to C, chromosome 15 at 102,082,059 bp
  • A to T, chromosome 16 at 5,239,956 bp
  • A to T, chromosome 16 at 33,987,176 bp
  • A to G, chromosome 17 at 24,974,735 bp
  • A to G, chromosome 17 at 26,036,664 bp
  • A to G, chromosome 17 at 35,123,253 bp
  • A to C, chromosome 17 at 35,620,783 bp
  • A to T, chromosome 17 at 37,903,828 bp
  • G to T, chromosome 19 at 5,873,368 bp
  • C to T, chromosome 19 at 13,838,639 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5716 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043187-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.