Strain Name:
C57BL/6J-MtgxR5720Btlr/Mmmh
Stock Number:
043188-MU
Citation ID:
RRID:MMRRC_043188-MU
Other Names:
R5720 (G1), C57BL/6J-MtgxR5720Btlr
Major Collection:

Gene Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 104245
Homologene: 37901
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: 2900073D12Rik, VGLUT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 140919
Homologene: 121617
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269800
Homologene: 15849
Xpo6
Name: exportin 6
Synonyms: Ranbp20, C230091E20Rik, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Dhtkd1
Name: dehydrogenase E1 and transketolase domain containing 1
Synonyms: C330018I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209692
Homologene: 10278
Serpind1
Name: serine (or cysteine) peptidase inhibitor, clade D, member 1
Synonyms: HC II, Hcf2, HCII, heparin cofactor II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15160
HGNC: HGNC:4838
Homologene: 36018
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 408022
Homologene: 14065
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
Trappc14
Name: trafficking protein particle complex 14
Synonyms: Map11, BC037034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231807
Homologene: 10106
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 270893
Homologene: 41524
Serpina12
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms: vaspin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68054
Homologene: 23588
Arhgef10l
Name: Rho guanine nucleotide exchange factor (GEF) 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72754
Homologene: 10017
Defb26
Name: defensin beta 26
Synonyms: EG654457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 654457
Homologene: 86850
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Olfr1250
Name: olfactory receptor 1250
Synonyms: GA_x6K02T2Q125-51098877-51097933, MOR231-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258967
Homologene: 128094
Skint8
Name: selection and upkeep of intraepithelial T cells 8
Synonyms: OTTMUSG00000009475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 639774
Homologene: 106613
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69387
Homologene: 70141
Fbxl7
Name: F-box and leucine-rich repeat protein 7
Synonyms: Fbl6, FBL7, D230018M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 448987
VEGA: 15
Homologene: 69121
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Spaca7
Name: sperm acrosome associated 7
Synonyms: 1700094C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78634
Homologene: 49754
Gpr65
Name: G-protein coupled receptor 65
Synonyms: TDAG8, Dig1, Gpcr25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14744
VEGA: 12
HGNC: HGNC:4517
Homologene: 2675
Rspo2
Name: R-spondin 2
Synonyms: 2610028F08Rik, ftls
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239405
VEGA: 15
Homologene: 18235
Ctf1
Name: cardiotrophin 1
Synonyms: CT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13019
HGNC: HGNC:2499
Homologene: 1016
Gm6430
Name: predicted gene 6430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 623430
Gm15559
Name: predicted gene 15559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100504049
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 97,024,858 bp
  • T to C, chromosome 2 at 5,903,014 bp
  • G to A, chromosome 2 at 12,111,087 bp
  • T to C, chromosome 2 at 89,656,955 bp
  • T to C, chromosome 2 at 152,508,202 bp
  • A to T, chromosome 4 at 81,287,694 bp
  • C to A, chromosome 4 at 111,950,193 bp
  • AGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGA, chromosome 4 at 140,581,619 bp
  • C to T, chromosome 5 at 110,777,718 bp
  • A to G, chromosome 5 at 138,263,702 bp
  • T to C, chromosome 6 at 125,036,624 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • C to T, chromosome 7 at 49,956,516 bp
  • C to T, chromosome 7 at 51,625,397 bp
  • A to T, chromosome 7 at 100,503,155 bp
  • T to C, chromosome 7 at 126,140,576 bp
  • A to T, chromosome 7 at 127,717,002 bp
  • A to G, chromosome 8 at 12,599,004 bp
  • A to G, chromosome 8 at 46,581,642 bp
  • C to G, chromosome 8 at 60,914,706 bp
  • T to C, chromosome 9 at 31,394,742 bp
  • T to C, chromosome 10 at 60,393,023 bp
  • G to A, chromosome 11 at 82,442,450 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • G to A, chromosome 12 at 75,967,667 bp
  • A to T, chromosome 12 at 98,275,102 bp
  • T to C, chromosome 12 at 104,038,304 bp
  • T to A, chromosome 15 at 8,203,687 bp
  • A to G, chromosome 15 at 26,552,893 bp
  • C to T, chromosome 15 at 43,169,814 bp
  • A to T, chromosome 16 at 17,339,832 bp
  • G to A, chromosome 18 at 10,542,427 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5720 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043188-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.