Strain Name:
C57BL/6J-MtgxR5737Btlr/Mmmh
Stock Number:
043195-MU
Citation ID:
RRID:MMRRC_043195-MU
Other Names:
R5737 (G1), C57BL/6J-MtgxR5737Btlr
Major Collection:

Gene Information

Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4921507G06Rik, 4930435C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11736
Homologene: 9491
Phka2
Name: phosphorylase kinase alpha 2
Synonyms: Phk, 6330505C01Rik, k
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 110094
HGNC: HGNC:8926
Homologene: 246
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71544
Homologene: 28446
4833439L19Rik
Name: RIKEN cDNA 4833439L19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 97820
Homologene: 10720
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: Dat1, DAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Tomt
Name: transmembrane O-methyltransferase
Synonyms: F930017I19Rik, Comt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 791260
Homologene: 19664
Lmo7
Name: LIM domain only 7
Synonyms: FBXO20, LOC380928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Psmg2
Name: proteasome (prosome, macropain) assembly chaperone 2
Synonyms: Clast3, Tnfsf5ip1, 1700017I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107047
VEGA: 18
Homologene: 41354
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: P1-Loop, Dnahc8, Hst6.7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Nelfa
Name: negative elongation factor complex member A, Whsc2
Synonyms: Whsc2h, Whsc2, Nelf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 24116
Homologene: 68478
Crtc2
Name: CREB regulated transcription coactivator 2
Synonyms: 4632407F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74343
Homologene: 18765
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: TFIIIC110, 1300004C11Rik, 2610510G03Rik, TFIIIC-BETA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: Dnahc11, avc4, b2b598Clo, lrd, b2b1289Clo, b2b1727Clo, b2b1279Clo, b2b1203Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Birc1b, Naip-rs6, Naip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56552
Homologene: 135915
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214575
Homologene: 18312
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Albfm1
Name: albumin superfamily member 1
Synonyms: 5830473C10Rik, Gm17754, ARG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622307
Homologene: 129803
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Kdr
Name: kinase insert domain protein receptor
Synonyms: VEGFR2, orv, VEGFR-2, vascular endothelial growth factor receptor- 2, VEGF receptor-2, Flk1, Flk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: Esdn, CLCP1, 1700055P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73379
Homologene: 12499
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320405
Homologene: 23060
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Tnfaip8l1
Name: tumor necrosis factor, alpha-induced protein 8-like 1
Synonyms: 2600017J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66443
Homologene: 23547
Ccer1
Name: coiled-coil glutamate-rich protein 1
Synonyms: 4921510H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66716
VEGA: 10
Homologene: 49839
Gm5533
Name: predicted gene 5533
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Tmem178b
Name: transmembrane protein 178B
Synonyms: A930009E05Rik, Gm5567
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434008
Homologene: 86704
Smim4
Name: small integral membrane protein 4
Synonyms: 2010107H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66487
Igkv8-24
Name: immunoglobulin kappa chain variable 8-24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 677858
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 156,300,724 bp
  • A to C, chromosome 1 at 181,852,180 bp
  • A to T, chromosome 2 at 13,388,891 bp
  • C to T, chromosome 3 at 90,260,204 bp
  • A to G, chromosome 5 at 31,168,249 bp
  • T to A, chromosome 5 at 33,899,113 bp
  • A to T, chromosome 5 at 75,961,696 bp
  • G to T, chromosome 5 at 90,572,783 bp
  • T to C, chromosome 6 at 23,328,805 bp
  • A to C, chromosome 6 at 40,245,641 bp
  • A to T, chromosome 6 at 70,217,138 bp
  • C to T, chromosome 6 at 118,741,932 bp
  • G to T, chromosome 6 at 124,039,449 bp
  • T to C, chromosome 7 at 101,900,317 bp
  • T to C, chromosome 7 at 120,059,198 bp
  • A to G, chromosome 8 at 16,358,347 bp
  • T to C, chromosome 9 at 9,059,068 bp
  • C to T, chromosome 9 at 45,745,185 bp
  • C to T, chromosome 9 at 96,570,665 bp
  • A to G, chromosome 9 at 107,526,747 bp
  • A to T, chromosome 10 at 17,915,714 bp
  • T to A, chromosome 10 at 83,520,325 bp
  • A to T, chromosome 10 at 97,694,684 bp
  • T to A, chromosome 11 at 72,732,274 bp
  • A to G, chromosome 12 at 118,192,390 bp
  • A to G, chromosome 13 at 54,559,242 bp
  • A to C, chromosome 13 at 73,544,804 bp
  • T to A, chromosome 13 at 100,161,854 bp
  • A to G, chromosome 14 at 31,128,719 bp
  • T to G, chromosome 14 at 101,887,236 bp
  • T to C, chromosome 16 at 58,460,985 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to G, chromosome 17 at 56,171,950 bp
  • T to C, chromosome 18 at 67,646,037 bp
  • A to C, chromosome 19 at 33,721,696 bp
  • C to T, chromosome 19 at 57,777,888 bp
  • ACC to AC, chromosome X at 160,559,866 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5737 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043195-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.