Strain Name:
C57BL/6J-MtgxR5740Btlr/Mmmh
Stock Number:
043196-MU
Citation ID:
RRID:MMRRC_043196-MU
Other Names:
R5740 (G1), C57BL/6J-MtgxR5740Btlr
Major Collection:

Gene Information

Fgg
Name: fibrinogen gamma chain
Synonyms: gamma-fibrinogen, 3010002H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99571
HGNC: HGNC:3694
Homologene: 429
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: Lpp2, mStbm, stbm, KITENIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229658
Homologene: 44540
Pan2
Name: PAN2 poly(A) specific ribonuclease subunit
Synonyms: 1200014O24Rik, Usp52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103135
VEGA: 10
Homologene: 5918
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66874
Homologene: 10231
Bag1
Name: BCL2-associated athanogene 1
Synonyms: Rap46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12017
HGNC: HGNC:937
Homologene: 3190
Fzd7
Name: frizzled class receptor 7
Synonyms: Fz7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14369
HGNC: HGNC:4045
Homologene: 20751
Zfp369
Name: zinc finger protein 369
Synonyms: NRIF2, D230020H11Rik, B930030B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 170936
Homologene: 129707
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: KA1, 6330551K01Rik, GluRgamma1, KA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: PP2BA beta, Calnb, CnAbeta, 1110063J16Rik, Cnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
M1ap
Name: meiosis 1 associated protein
Synonyms: D6Mm5e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110958
Homologene: 13210
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, 4632409L19Rik, Inoc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68142
Homologene: 75070
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: CCCAP, 2700048G21Rik, 5730470G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76816
Homologene: 4839
Gja1
Name: gap junction protein, alpha 1
Synonyms: connexin 43, Cx43, alpha 1 connexin, connexin43, Gja-1, Cx43alpha1, Cnx43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14609
VEGA: 10
HGNC: HGNC:4274
Homologene: 136
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67569
Homologene: 8297
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70885
Homologene: 10029
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Cyp2d41-ps
Name: cytochrome P450, family 2, subfamily d, member 41, pseudogene
Synonyms: Gm5062
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 271300
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
4921513I03Rik
Name: RIKEN cDNA 4921513I03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70874
VEGA: 10
Golgb1
Name: golgi autoantigen, golgin subfamily b, macrogolgin 1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329152
Homologene: 66192
Rpl9
Name: ribosomal protein L9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20005
Homologene: 90855
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Olfr1453
Name: olfactory receptor 1453
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258695
Homologene: 120159
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319217
Homologene: 129754
Vmn1r52
Name: vomeronasal 1 receptor 52
Synonyms: VN3, V1ra7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113849
Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Synonyms: NIS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 114479
Homologene: 37311
Arrdc5
Name: arrestin domain containing 5
Synonyms: 1700013E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76920
VEGA: 17
Homologene: 66277
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231147
Homologene: 10360
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383258
Homologene: 129687
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, E030045D18Rik, 2900056N03Rik, Shn3, Schnurri-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16656
Homologene: 7803
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glur-6, Glur6, Glurbeta2, C130030K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Mcub
Name: mitochondrial calcium uniporter dominant negative beta subunit
Synonyms: 9030408N13Rik, Ccdc109b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66815
Homologene: 23056
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71706
Homologene: 41733
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100417675
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,337,915 bp
  • T to C, chromosome 1 at 53,887,603 bp
  • A to G, chromosome 1 at 59,483,680 bp
  • A to G, chromosome 1 at 176,831,150 bp
  • T to C, chromosome 2 at 76,891,374 bp
  • T to C, chromosome 2 at 119,431,029 bp
  • T to C, chromosome 3 at 64,707,233 bp
  • A to T, chromosome 3 at 83,011,525 bp
  • A to G, chromosome 3 at 86,328,342 bp
  • T to C, chromosome 3 at 102,184,134 bp
  • A to T, chromosome 3 at 129,918,725 bp
  • T to C, chromosome 4 at 40,941,526 bp
  • A to G, chromosome 4 at 120,096,023 bp
  • T to C, chromosome 5 at 35,707,055 bp
  • G to A, chromosome 5 at 65,391,035 bp
  • A to T, chromosome 5 at 147,879,833 bp
  • T to C, chromosome 6 at 82,981,922 bp
  • T to A, chromosome 6 at 90,179,194 bp
  • G to A, chromosome 7 at 14,580,975 bp
  • T to C, chromosome 7 at 44,353,740 bp
  • G to A, chromosome 8 at 68,804,922 bp
  • G to T, chromosome 8 at 70,888,917 bp
  • C to T, chromosome 9 at 42,808,567 bp
  • T to C, chromosome 10 at 49,113,477 bp
  • G to A, chromosome 10 at 56,388,189 bp
  • A to T, chromosome 10 at 102,389,321 bp
  • G to A, chromosome 10 at 120,778,508 bp
  • G to A, chromosome 10 at 128,308,164 bp
  • T to A, chromosome 11 at 73,053,497 bp
  • A to T, chromosome 11 at 97,236,068 bp
  • T to C, chromosome 13 at 36,898,204 bp
  • A to G, chromosome 13 at 65,296,767 bp
  • T to A, chromosome 13 at 100,432,501 bp
  • A to T, chromosome 14 at 20,501,596 bp
  • T to C, chromosome 15 at 5,057,040 bp
  • G to T, chromosome 15 at 82,779,220 bp
  • T to C, chromosome 15 at 98,544,500 bp
  • T to C, chromosome 16 at 36,919,000 bp
  • C to T, chromosome 17 at 55,593,103 bp
  • T to A, chromosome 17 at 56,297,838 bp
  • T to C, chromosome 19 at 13,027,562 bp
  • A to G, chromosome 19 at 29,262,424 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5740 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043196-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.