Strain Name:
C57BL/6J-MtgxR5751Btlr/Mmmh
Stock Number:
043201-MU
Citation ID:
RRID:MMRRC_043201-MU
Other Names:
R5751 (G1), C57BL/6J-MtgxR5751Btlr
Major Collection:

Gene Information

Lhx3
Name: LIM homeobox protein 3
Synonyms: P-LIM, mLim-3, Lim3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16871
HGNC: HGNC:6595
Homologene: 7814
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228829
Homologene: 9507
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Ago2
Name: argonaute RISC catalytic subunit 2
Synonyms: argonaute 2, 1110029L17Rik, 2310051F07Rik, Eif2c2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239528
HGNC: HGNC:3263
Homologene: 81825
Emc2
Name: ER membrane protein complex subunit 2
Synonyms: 4921531G14Rik, Ttc35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66736
VEGA: 15
Homologene: 8785
Orc5
Name: origin recognition complex, subunit 5
Synonyms: mouse origin recognition complex 5, MmORC5, Orc5l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26429
HGNC: HGNC:8491
Homologene: 37636
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Ik
Name: IK cytokine
Synonyms: MuRED
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 24010
VEGA: 18
HGNC: HGNC:5958
Homologene: 36193
Grpel1
Name: GrpE-like 1, mitochondrial
Synonyms: mt-GrpE#1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17713
Homologene: 6992
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171395
Homologene: 51376
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 665113
Homologene: 77943
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: 1110007H10Rik, Urkl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68556
Homologene: 101414
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381852
Homologene: 115938
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212892
Homologene: 71779
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Vmn2r90
Name: vomeronasal 2, receptor 90
Synonyms: EG626942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 626942
Ranbp3l
Name: RAN binding protein 3-like
Synonyms: C130037N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223332
VEGA: 15
Homologene: 35407
Gtf3c4
Name: general transcription factor IIIC, polypeptide 4
Synonyms: KAT12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269252
HGNC: HGNC:4667
Homologene: 8147
Olfr1440
Name: olfactory receptor 1440
Synonyms: GA_x6K02T2RE5P-2725206-2726153, MOR215-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258679
Homologene: 128133
Olfr1239
Name: olfactory receptor 1239
Synonyms: GA_x6K02T2Q125-50861284-50860367, MOR231-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258972
Homologene: 74244
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, 4930544G21Rik, SKIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77629
Homologene: 18172
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 236573
Homologene: 128731
Olfr128
Name: olfactory receptor 128
Synonyms: GA_x6K02T2PSCP-2374126-2375048, MOR218-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383243
Homologene: 134080
Ldc1
Name: leucine decarboxylase 1
Synonyms: LOC332942, Gm853
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 332942
Homologene: 128653
Aqp7
Name: aquaporin 7
Synonyms: AQP7L, AQPap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11832
HGNC: HGNC:640
Homologene: 48000
Tacr2
Name: tachykinin receptor 2
Synonyms: Tac2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21337
VEGA: 10
Homologene: 55548
Tmem200c
Name: transmembrane protein 200C
Synonyms: Gm6338
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 622645
VEGA: 17
Homologene: 78765
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238662
VEGA: 13
RP24-349N15.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
RP23-3M10.11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 83,275,897 bp
  • A to G, chromosome 1 at 150,573,554 bp
  • A to G, chromosome 2 at 26,201,161 bp
  • C to T, chromosome 2 at 28,827,499 bp
  • A to T, chromosome 2 at 89,417,687 bp
  • T to C, chromosome 2 at 156,267,341 bp
  • A to G, chromosome 2 at 181,574,452 bp
  • T to C, chromosome 3 at 28,594,092 bp
  • T to A, chromosome 3 at 135,963,603 bp
  • G to A, chromosome 4 at 41,035,510 bp
  • A to C, chromosome 4 at 130,220,441 bp
  • C to T, chromosome 5 at 22,499,971 bp
  • C to T, chromosome 5 at 36,469,467 bp
  • G to T, chromosome 5 at 105,081,258 bp
  • A to G, chromosome 5 at 114,230,832 bp
  • C to A, chromosome 5 at 114,715,940 bp
  • C to T, chromosome 5 at 137,410,161 bp
  • C to A, chromosome 7 at 17,902,557 bp
  • A to G, chromosome 8 at 22,018,128 bp
  • C to T, chromosome 10 at 33,905,793 bp
  • T to C, chromosome 10 at 58,464,264 bp
  • T to C, chromosome 10 at 62,252,990 bp
  • T to C, chromosome 11 at 8,867,204 bp
  • T to A, chromosome 12 at 8,012,619 bp
  • T to A, chromosome 12 at 113,544,827 bp
  • T to A, chromosome 13 at 59,718,973 bp
  • T to A, chromosome 13 at 81,522,236 bp
  • T to A, chromosome 14 at 31,310,906 bp
  • C to A, chromosome 14 at 103,148,550 bp
  • A to G, chromosome 15 at 9,063,089 bp
  • A to G, chromosome 15 at 43,497,057 bp
  • C to T, chromosome 15 at 73,128,323 bp
  • A to G, chromosome 17 at 17,733,866 bp
  • A to T, chromosome 17 at 37,923,970 bp
  • A to G, chromosome 17 at 49,449,738 bp
  • A to T, chromosome 17 at 68,840,552 bp
  • G to A, chromosome 18 at 36,753,513 bp
  • A to T, chromosome 18 at 43,305,020 bp
  • G to A, chromosome 19 at 12,394,416 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5751 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043201-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.