Strain Name:
C57BL/6J-MtgxR5758Btlr/Mmmh
Stock Number:
043203-MU
Citation ID:
RRID:MMRRC_043203-MU
Other Names:
R5758 (G1), C57BL/6J-MtgxR5758Btlr
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: bt, ADAMTS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223838
Homologene: 11808
Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: D130071N24Rik, A230053P19Rik, Hip14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320150
VEGA: 10
Homologene: 56324
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: Pdzgef2, RA-GEF-2, C030018K18Rik, PDZ-GEF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192786
Homologene: 22968
Sar1a
Name: secretion associated Ras related GTPase 1A
Synonyms: 1600019H17Rik, Sara1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20224
VEGA: 10
Homologene: 90897
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 9030409G11Rik, 2310007B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71529
Homologene: 16235
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: 2410002G23Rik, D13Ertd328e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69716
Homologene: 3125
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: mStbm, KITENIN, Lpp2, stbm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229658
Homologene: 44540
Orc5
Name: origin recognition complex, subunit 5
Synonyms: Orc5l, MmORC5, mouse origin recognition complex 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26429
HGNC: HGNC:8491
Homologene: 37636
Dmxl2
Name: Dmx-like 2
Synonyms: 6430411K14Rik, E130119P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Smim17
Name: small integral membrane protein 17
Synonyms: Gm16532
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042450
Homologene: 104897
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: 0610031J06Rik, NCU-G1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56700
Homologene: 10562
Nipal3
Name: NIPA-like domain containing 3
Synonyms: Npal3, 9130020G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74552
Homologene: 10722
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329002
Homologene: 7198
Dpys
Name: dihydropyrimidinase
Synonyms: 1200017I10Rik, 1300004I01Rik, DHPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64705
HGNC: HGNC:3013
Homologene: 20359
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Dpy19l4
Name: dpy-19-like 4 (C. elegans)
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381510
Homologene: 18773
Olfml2b
Name: olfactomedin-like 2B
Synonyms: 1110018N05Rik, photomedin-2, 4832415H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320078
Homologene: 18546
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh-4, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Crsh, crash, Scy, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: 1110007H10Rik, Urkl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68556
Homologene: 101414
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16578
Homologene: 65620
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245026
Homologene: 18260
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Apbb1
Name: amyloid beta (A4) precursor protein-binding, family B, member 1
Synonyms: Rir, Fe65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Synonyms: LH-R, Lhr, Gpcr19-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16867
VEGA: 17
HGNC: HGNC:6585
Homologene: 37276
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20419
Homologene: 32123
Trim10
Name: tripartite motif-containing 10
Synonyms: Rnf9, Herf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19824
Homologene: 4932
Olfr467
Name: olfactory receptor 467
Synonyms: MOR204-33P, GA_x6K02T2PBJ9-10144091-10145011
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257919
Homologene: 81542
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: UGT1.6, Ugt1a6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94284
Homologene: 85959
Zfp563
Name: zinc finger protein 563
Synonyms: zinc finger protein, Zfp413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240068
Homologene: 77346
Acan
Name: aggrecan
Synonyms: Agc1, Cspg1, b2b183Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Gm101, Pcdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226356
Homologene: 88578
Mrgprb3
Name: MAS-related GPR, member B3
Synonyms: MrgB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404238
Homologene: 138632
Olfr497
Name: olfactory receptor 497
Synonyms: GA_x6K02T2PBJ9-10752603-10753547, MOR204-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258733
Homologene: 133602
Hebp2
Name: heme binding protein 2
Synonyms: SOUL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56016
VEGA: 10
Homologene: 8634
Zfp703
Name: zinc finger protein 703
Synonyms: End2, Csmn1, 1110032O19Rik, Zeppo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353310
Homologene: 81391
AF067063
Name: cDNA sequence AF067063
Synonyms: clone L5, clone L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380878
Igkv8-21
Name: immunoglobulin kappa variable 8-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 620400
Calhm3
Name: calcium homeostasis modulator 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240669
VEGA: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,138,758 bp
  • A to G, chromosome 1 at 119,934,558 bp
  • G to A, chromosome 1 at 170,669,264 bp
  • T to C, chromosome 2 at 57,998,430 bp
  • G to A, chromosome 2 at 112,841,975 bp
  • C to A, chromosome 2 at 181,569,953 bp
  • A to G, chromosome 3 at 5,402,620 bp
  • A to C, chromosome 3 at 88,326,437 bp
  • A to T, chromosome 3 at 102,184,092 bp
  • C to T, chromosome 4 at 11,276,886 bp
  • T to C, chromosome 4 at 135,452,563 bp
  • A to G, chromosome 4 at 142,141,671 bp
  • T to C, chromosome 5 at 22,529,258 bp
  • A to T, chromosome 6 at 70,315,025 bp
  • C to T, chromosome 7 at 6,424,789 bp
  • C to A, chromosome 7 at 48,643,319 bp
  • A to T, chromosome 7 at 79,101,214 bp
  • C to T, chromosome 7 at 105,559,548 bp
  • T to C, chromosome 7 at 107,814,815 bp
  • T to A, chromosome 7 at 108,423,162 bp
  • A to T, chromosome 7 at 141,858,983 bp
  • T to C, chromosome 8 at 4,749,355 bp
  • C to T, chromosome 8 at 26,979,205 bp
  • T to A, chromosome 9 at 54,472,964 bp
  • T to C, chromosome 9 at 105,761,518 bp
  • T to C, chromosome 9 at 110,489,879 bp
  • C to A, chromosome 10 at 18,544,407 bp
  • A to G, chromosome 10 at 61,685,072 bp
  • A to G, chromosome 10 at 110,944,395 bp
  • A to G, chromosome 11 at 9,314,536 bp
  • A to G, chromosome 11 at 54,668,644 bp
  • T to C, chromosome 11 at 60,708,567 bp
  • G to T, chromosome 13 at 73,937,495 bp
  • T to C, chromosome 13 at 119,828,255 bp
  • A to C, chromosome 15 at 39,826,999 bp
  • C to T, chromosome 15 at 85,941,264 bp
  • T to C, chromosome 15 at 94,394,650 bp
  • A to G, chromosome 17 at 33,104,920 bp
  • C to T, chromosome 17 at 36,877,152 bp
  • T to C, chromosome 17 at 67,873,159 bp
  • T to C, chromosome 17 at 88,742,548 bp
  • A to G, chromosome 18 at 19,989,534 bp
  • G to A, chromosome 18 at 82,671,709 bp
  • T to A, chromosome 19 at 29,309,643 bp
  • A to G, chromosome 19 at 47,151,751 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5758 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043203-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.