Strain Name:
C57BL/6J-MtgxR5780Btlr/Mmmh
Stock Number:
043205-MU
Citation ID:
RRID:MMRRC_043205-MU
Other Names:
R5780 (G1), C57BL/6J-MtgxR5780Btlr
Major Collection:

Gene Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: X99384, paladin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 27355
VEGA: 10
Homologene: 8453
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Avp
Name: arginine vasopressin
Synonyms: Vp, Vsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11998
HGNC: HGNC:894
Homologene: 417
Sema3f
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms: Semak, Sema IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20350
Homologene: 20885
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67422
Homologene: 32615
Clasp2
Name: CLIP associating protein 2
Synonyms: CLASP2alpha, 1500004F14Rik, CLASP2, 8030404L10Rik, CLASP2gamma, CLASP2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76499
VEGA: 9
Homologene: 24944
Ube4b
Name: ubiquitination factor E4B
Synonyms: 4930551I19Rik, Ufd2p, D4Bwg0973e, UFD2a, UFD2, 4933406G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 63958
Homologene: 107623
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100019
Homologene: 39689
Atp6v1a
Name: ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms: Atp6a1, VA68, VPP2, lysosomal 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11964
HGNC: HGNC:851
Homologene: 123934
Gm14124
Name: predicted gene 14124
Synonyms: Gm10749, EG640962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100216455
Homologene: 134546
Thbs1
Name: thrombospondin 1
Synonyms: TSP-1, tbsp1, TSP1, Thbs-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21825
Homologene: 31142
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, Dnahc7a, LOC381341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 627872
Homologene: 41287
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, eyes2, crf11, QBRICK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329872
Homologene: 27049
Dmkn
Name: dermokine
Synonyms: sk89, sk30, dermokine, cI-36, 1110014F24Rik, Dmkn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 73712
Homologene: 136295
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20743
VEGA: 19
Homologene: 48482
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68449
Homologene: 9177
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Soga1
Name: suppressor of glucose, autophagy associated 1
Synonyms: 9830001H06Rik, D430036N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320706
Homologene: 52382
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: Csm, CHAMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: LOC218175, Gm40956, EG621792
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 637277
Homologene: 52882
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 665113
Homologene: 77943
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hy-3, hy3, 1700034M11Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244653
Homologene: 52118
Apoa4
Name: apolipoprotein A-IV
Synonyms: Apoa-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11808
HGNC: HGNC:602
Homologene: 47927
Afm
Name: afamin
Synonyms: alpha albumin, Alf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329628
Homologene: 14377
Stard9
Name: START domain containing 9
Synonyms: E230025N21Rik, 4831403C07Rik, Kif16a, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668880
Homologene: 130712
Gm12794
Name: predicted gene 12794
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 332923
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 71768
VEGA: 19
Homologene: 17651
Olfr869
Name: olfactory receptor 869
Synonyms: MOR145-6, GA_x6K02T2PVTD-13878275-13879204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258550
Homologene: 138312
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19886
Homologene: 2207
Mgarp
Name: mitochondria localized glutamic acid rich protein
Synonyms: 4930583H14Rik, Osap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67749
Homologene: 49858
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: mpk2, 6720451F06Rik, 6230400G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243548
Homologene: 17889
Nxpe3
Name: neurexophilin and PC-esterase domain family, member 3
Synonyms: LOC208684, Fam55c, LOC385658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 385658
VEGA: 16
Homologene: 17030
Mmp13
Name: matrix metallopeptidase 13
Synonyms: Clg, Mmp1, Collagenase-3, collagenase-1, MMP-13, interstitial collagenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17386
VEGA: 9
HGNC: HGNC:7159
Homologene: 20548
Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Synonyms: 11HSD2, 11(beta)-HSD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 15484
HGNC: HGNC:5209
Homologene: 20088
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5-LOX, 5LO, 5LX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216188
Homologene: 51942
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 215384
Homologene: 68369
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: ahl8, C630046B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Ica1l
Name: islet cell autoantigen 1-like
Synonyms: b2b3465Clo, Als2cr15, 1700030B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70375
Homologene: 16323
Olfr1287
Name: olfactory receptor 1287
Synonyms: GA_x6K02T2Q125-72500603-72501520, MOR248-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257935
A630001G21Rik
Name: RIKEN cDNA A630001G21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 319997
Homologene: 79992
Olfr784
Name: olfactory receptor 784
Synonyms: GA_x6K02T2PULF-11068246-11069205, MOR110-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258724
Homologene: 138306
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66971
Homologene: 9502
Acsm4
Name: acyl-CoA synthetase medium-chain family member 4
Synonyms: OMACS, O-MACS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233801
Homologene: 72281
Hrh3
Name: histamine receptor H3
Synonyms: Eae8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99296
HGNC: HGNC:5184
Homologene: 5232
Gm9696
Name: predicted gene 9696
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 676914
Hmga2
Name: high mobility group AT-hook 2
Synonyms: HMGI-C, 9430083A20Rik, Hmgic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15364
HGNC: HGNC:5009
Homologene: 2602
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 53,483,319 bp
  • C to A, chromosome 1 at 60,028,215 bp
  • C to T, chromosome 1 at 85,718,318 bp
  • A to T, chromosome 2 at 111,449,833 bp
  • T to C, chromosome 2 at 118,122,965 bp
  • T to C, chromosome 2 at 120,703,396 bp
  • A to G, chromosome 2 at 130,580,709 bp
  • T to A, chromosome 2 at 150,266,219 bp
  • CTT to CT, chromosome 2 at 154,345,868 bp
  • C to T, chromosome 2 at 156,496,525 bp
  • A to G, chromosome 2 at 157,018,490 bp
  • A to T, chromosome 2 at 180,100,815 bp
  • T to C, chromosome 3 at 28,594,092 bp
  • T to C, chromosome 3 at 38,980,955 bp
  • T to C, chromosome 3 at 51,391,848 bp
  • A to T, chromosome 3 at 59,972,088 bp
  • C to T, chromosome 4 at 32,722,950 bp
  • T to C, chromosome 4 at 82,950,415 bp
  • C to T, chromosome 4 at 101,941,527 bp
  • G to A, chromosome 4 at 133,996,830 bp
  • C to T, chromosome 4 at 149,331,364 bp
  • A to G, chromosome 5 at 90,551,431 bp
  • T to C, chromosome 6 at 92,458,612 bp
  • A to T, chromosome 6 at 116,420,349 bp
  • A to T, chromosome 7 at 15,979,754 bp
  • T to A, chromosome 7 at 28,085,218 bp
  • A to G, chromosome 7 at 30,777,615 bp
  • A to G, chromosome 7 at 119,693,845 bp
  • G to A, chromosome 7 at 127,198,753 bp
  • G to A, chromosome 8 at 105,522,155 bp
  • T to C, chromosome 8 at 110,586,080 bp
  • T to G, chromosome 9 at 7,278,952 bp
  • T to A, chromosome 9 at 20,137,497 bp
  • A to G, chromosome 9 at 46,242,592 bp
  • A to G, chromosome 9 at 107,682,589 bp
  • T to G, chromosome 9 at 113,850,152 bp
  • A to T, chromosome 10 at 52,194,857 bp
  • A to T, chromosome 10 at 61,339,218 bp
  • T to C, chromosome 10 at 83,493,521 bp
  • T to A, chromosome 10 at 120,462,678 bp
  • T to C, chromosome 10 at 129,388,070 bp
  • A to C, chromosome 11 at 120,366,668 bp
  • A to G, chromosome 13 at 41,129,500 bp
  • A to G, chromosome 15 at 89,011,978 bp
  • A to T, chromosome 16 at 44,114,643 bp
  • T to A, chromosome 16 at 55,866,441 bp
  • T to A, chromosome 19 at 4,724,667 bp
  • C to A, chromosome 19 at 10,650,619 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5780 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043205-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.