Strain Name:
C57BL/6J-MtgxR5797Btlr/Mmmh
Stock Number:
043209-MU
Citation ID:
RRID:MMRRC_043209-MU
Other Names:
R5797 (G1), C57BL/6J-MtgxR5797Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319582
Homologene: 35306
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Kif2a
Name: kinesin family member 2A
Synonyms: Kns2, Kif2, M-kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16563
HGNC: HGNC:6318
Homologene: 3320
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Sdha
Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms: SDHF, SDH2, FP, 2310034D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66945
Homologene: 3073
Ddx47
Name: DEAD box helicase 47
Synonyms: 4930588A18Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67755
Homologene: 6092
Nf2
Name: neurofibromin 2
Synonyms: schwannomin, merlin, moesin-ezrin-radixin-like protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Dmap1
Name: DNA methyltransferase 1-associated protein 1
Synonyms: 1500016M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66233
Homologene: 41311
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 386750
Homologene: 8955
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20741
Homologene: 295
Mpzl3
Name: myelin protein zero-like 3
Synonyms: 5430427F17Rik, A530065I17Rik, rc, ruf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319742
Homologene: 18867
Ms4a6d
Name: membrane-spanning 4-domains, subfamily A, member 6D
Synonyms: Ms4a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68774
Homologene: 130755
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77627
Homologene: 11259
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Scd3
Name: stearoyl-coenzyme A desaturase 3
Synonyms: 4930513N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 30049
VEGA: 19
Homologene: 137370
Fshr
Name: follicle stimulating hormone receptor
Synonyms: follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Abhd18
Name: abhydrolase domain containing 18
Synonyms: 3110057O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269423
Homologene: 105457
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50798
Homologene: 3996
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Dhx30
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 30
Synonyms: Ddx30, 2810477H02Rik, C130058C04Rik, helG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72831
Homologene: 15779
Fbrs
Name: fibrosin
Synonyms: Fbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14123
Homologene: 79554
Lrrtm2
Name: leucine rich repeat transmembrane neuronal 2
Synonyms: C630011A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107065
VEGA: 18
Homologene: 65342
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: 4933427B05Rik, SYPH1, synphilin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67847
Homologene: 3987
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H, C330017E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227394
Homologene: 62654
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: GGT, CD224, Ggtp, dwg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14598
HGNC: HGNC:4250
Homologene: 68450
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627569
Homologene: 129606
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 117066
VEGA: 13
Gja3
Name: gap junction protein, alpha 3
Synonyms: connexin 46, alpha 3 connexin, Gja-3, Cx46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14611
VEGA: 14
HGNC: HGNC:4277
Homologene: 9670
Gnmt
Name: glycine N-methyltransferase
Synonyms: glycine N methyl transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14711
HGNC: HGNC:4415
Homologene: 7741
Amz2
Name: archaelysin family metallopeptidase 2
Synonyms: ESTM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100503496
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Gm572
Name: predicted gene 572
Synonyms: LOC230909, b2b1167Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230909
Homologene: 52134
Cyb5rl
Name: cytochrome b5 reductase-like
Synonyms: 2810410C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230582
Homologene: 45506
Gm5454
Name: predicted gene 5454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432800
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 96,819,104 bp
  • T to C, chromosome 3 at 40,933,551 bp
  • T to A, chromosome 3 at 73,048,629 bp
  • G to A, chromosome 4 at 44,060,030 bp
  • A to T, chromosome 4 at 107,084,207 bp
  • A to T, chromosome 4 at 117,675,480 bp
  • G to A, chromosome 4 at 148,666,798 bp
  • A to T, chromosome 5 at 109,085,870 bp
  • A to G, chromosome 5 at 124,821,386 bp
  • A to G, chromosome 5 at 150,991,538 bp
  • A to G, chromosome 6 at 31,433,069 bp
  • C to T, chromosome 6 at 135,023,413 bp
  • A to G, chromosome 7 at 30,712,649 bp
  • C to A, chromosome 7 at 127,487,291 bp
  • C to A, chromosome 7 at 141,851,582 bp
  • A to T, chromosome 8 at 36,498,415 bp
  • A to T, chromosome 9 at 45,062,135 bp
  • T to A, chromosome 9 at 48,396,538 bp
  • A to G, chromosome 9 at 58,219,821 bp
  • T to C, chromosome 9 at 110,098,820 bp
  • T to C, chromosome 10 at 75,585,367 bp
  • T to C, chromosome 10 at 76,392,756 bp
  • T to A, chromosome 10 at 92,967,576 bp
  • A to T, chromosome 11 at 4,808,831 bp
  • T to C, chromosome 11 at 50,301,017 bp
  • G to T, chromosome 11 at 109,427,079 bp
  • T to C, chromosome 12 at 76,603,699 bp
  • A to T, chromosome 13 at 61,568,392 bp
  • A to T, chromosome 13 at 74,334,357 bp
  • T to C, chromosome 13 at 100,444,526 bp
  • A to T, chromosome 13 at 103,357,420 bp
  • A to T, chromosome 13 at 106,975,376 bp
  • T to C, chromosome 14 at 57,035,713 bp
  • C to T, chromosome 15 at 83,924,277 bp
  • T to A, chromosome 16 at 15,737,834 bp
  • T to C, chromosome 16 at 34,212,249 bp
  • T to A, chromosome 17 at 24,592,641 bp
  • T to C, chromosome 17 at 46,726,379 bp
  • T to G, chromosome 17 at 89,011,075 bp
  • C to T, chromosome 18 at 35,213,706 bp
  • A to T, chromosome 18 at 52,898,204 bp
  • A to G, chromosome 18 at 74,701,521 bp
  • T to C, chromosome 19 at 11,590,062 bp
  • T to C, chromosome 19 at 44,215,511 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5797 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043209-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.