Strain Name:
C57BL/6J-MtgxR5823Btlr/Mmmh
Stock Number:
043215-MU
Citation ID:
RRID:MMRRC_043215-MU
Other Names:
R5823 (G1), C57BL/6J-MtgxR5823Btlr
Major Collection:

Strain Information

Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100502698
Homologene: 15687
Wdr47
Name: WD repeat domain 47
Synonyms: 1810073M12Rik, nemitin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99512
Homologene: 8984
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Trim36
Name: tripartite motif-containing 36
Synonyms: D18Wsu100e, Haprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Ddx47
Name: DEAD box helicase 47
Synonyms: 4930588A18Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67755
Homologene: 6092
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98956
Homologene: 6785
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: D18Ertd139e, D18Ertd723e, C85354, lcsd, A430089E03Rik, nmf164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Nipsnap2
Name: nipsnap homolog 2
Synonyms: Nipsnap2, Gbas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14467
HGNC: HGNC:4179
Homologene: 1137
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: 2610510B12Rik, C85929, Facl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110895
Homologene: 72232
Lmo2
Name: LIM domain only 2
Synonyms: Rbtn-2, Rbtn2, Rhom-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16909
HGNC: HGNC:6642
Homologene: 4072
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Mgat4f
Name: MGAT4 family, member F
Synonyms: 4933406M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240755
Homologene: 128441
Smco2
Name: single-pass membrane protein with coiled-coil domains 2
Synonyms: 1700023A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69371
Homologene: 106211
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
Or2r3
Name: olfactory receptor family 2 subfamily R member 3
Synonyms: GA_x6K02T2P3E9-5088893-5089834, MOR257-1, Olfr457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258989
Homologene: 133701
Rasgrp4
Name: RAS guanyl releasing protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233046
Homologene: 15635
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Cwh43
Name: cell wall biogenesis 43 C-terminal homolog
Synonyms: C130090K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231293
Homologene: 5474
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, MLCK108, 9530072E15Rik, A930019C19Rik, nmMlck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210417
Homologene: 18180
Tas2r118
Name: taste receptor, type 2, member 118
Synonyms: Tas2r18, mGR18, mt2r40, T2R18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387347
Homologene: 9660
Slfn8
Name: schlafen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276950
Homologene: 45432
Wdr77
Name: WD repeat domain 77
Synonyms: 2610312E17Rik, p44/MEP50, 2610003I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70465
Homologene: 11466
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219150
Homologene: 11589
Fcf1
Name: FCF1 rRNA processing protein
Synonyms: 1110008B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73736
Homologene: 5706
4930505A04Rik
Name: RIKEN cDNA 4930505A04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75087
Homologene: 18988
Hcn1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms: HAC2, Bcng1, C630013B14Rik, hyperpolarization-activated, cyclic nucleotide-gated K+ 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15165
HGNC: HGNC:4845
Homologene: 32093
Nfu1
Name: NFU1 iron-sulfur cluster scaffold
Synonyms: 0610006G17Rik, CGI-33, Hirip5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56748
Homologene: 6369
Trim63
Name: tripartite motif-containing 63
Synonyms: MuRF1, Rnf28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433766
Homologene: 41878
Iqcf4
Name: IQ motif containing F4
Synonyms: 1700042N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67320
Homologene: 122079
Slc30a2
Name: solute carrier family 30 (zinc transporter), member 2
Synonyms: Znt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230810
Homologene: 40855
Fut7
Name: fucosyltransferase 7
Synonyms: Fuc-TVII, FucT-VII, FTVII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14347
HGNC: HGNC:4018
Homologene: 3296
Snx21
Name: sorting nexin family member 21
Synonyms: 5730407K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 101113
Homologene: 43132
Slc35d2
Name: solute carrier family 35, member D2
Synonyms: UGTrel8, SQV7L, hfrc, 5730408I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70484
VEGA: 13
Homologene: 68119
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Gm38119
Name: predicted gene, 38119
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm28496
Name: predicted gene 28496
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,804,683 bp
  • T to A, chromosome 1 at 40,619,117 bp
  • G to T, chromosome 1 at 78,688,286 bp
  • T to C, chromosome 1 at 129,678,084 bp
  • T to A, chromosome 1 at 134,390,917 bp
  • T to C, chromosome 2 at 25,424,980 bp
  • A to T, chromosome 2 at 103,730,267 bp
  • C to T, chromosome 2 at 103,981,072 bp
  • C to T, chromosome 2 at 164,791,563 bp
  • T to A, chromosome 2 at 180,192,492 bp
  • T to C, chromosome 2 at 181,236,396 bp
  • G to T, chromosome 3 at 92,738,073 bp
  • T to C, chromosome 3 at 105,960,005 bp
  • G to A, chromosome 3 at 108,643,085 bp
  • A to T, chromosome 4 at 134,316,531 bp
  • T to C, chromosome 4 at 134,345,978 bp
  • A to G, chromosome 4 at 141,955,306 bp
  • A to G, chromosome 5 at 73,411,870 bp
  • T to A, chromosome 5 at 129,739,769 bp
  • A to G, chromosome 6 at 23,969,471 bp
  • T to C, chromosome 6 at 29,461,202 bp
  • C to A, chromosome 6 at 42,471,972 bp
  • T to A, chromosome 6 at 48,930,552 bp
  • C to A, chromosome 6 at 87,025,559 bp
  • A to G, chromosome 6 at 125,168,700 bp
  • C to A, chromosome 6 at 135,016,641 bp
  • C to T, chromosome 6 at 146,856,063 bp
  • G to T, chromosome 7 at 29,137,717 bp
  • T to C, chromosome 7 at 44,261,148 bp
  • A to G, chromosome 8 at 33,570,934 bp
  • A to T, chromosome 8 at 122,895,790 bp
  • T to A, chromosome 9 at 21,804,828 bp
  • T to C, chromosome 9 at 106,568,601 bp
  • C to A, chromosome 10 at 75,038,373 bp
  • A to G, chromosome 11 at 6,517,132 bp
  • C to T, chromosome 11 at 30,426,349 bp
  • A to G, chromosome 11 at 67,360,468 bp
  • A to G, chromosome 11 at 83,016,736 bp
  • A to G, chromosome 12 at 84,974,147 bp
  • A to G, chromosome 13 at 64,120,605 bp
  • A to T, chromosome 13 at 117,602,852 bp
  • G to T, chromosome 14 at 31,266,418 bp
  • A to G, chromosome 14 at 64,896,994 bp
  • T to A, chromosome 15 at 58,590,503 bp
  • T to C, chromosome 16 at 32,849,721 bp
  • T to A, chromosome 16 at 34,894,947 bp
  • T to C, chromosome 18 at 12,191,789 bp
  • A to G, chromosome 18 at 46,169,340 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5823 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043215-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.