Strain Name:
C57BL/6J-MtgxR5826Btlr/Mmmh
Stock Number:
043217-MU
Citation ID:
RRID:MMRRC_043217-MU
Other Names:
R5826 (G1), C57BL/6J-MtgxR5826Btlr
Major Collection:

Strain Information

Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: MTGR1, C330013D05Rik, Cbfa2t2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: XRCC7, DOXNPH, dxnph, DNAPDcs, slip, DNA-PKcs, DNA-PK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Slc16a3
Name: solute carrier family 16 (monocarboxylic acid transporters), member 3
Synonyms: MCT4, MCT3, monocarboxylate transporter 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80879
Homologene: 37900
Nfkbil1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
Synonyms: Def-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18038
HGNC: HGNC:7800
Homologene: 3671
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: 17[b]-HSD, Mfp-2, D-bifunctional protein, MFP2, MFE-2, perMFE-2, multifunctional protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67812
Homologene: 40962
Plcg2
Name: phospholipase C, gamma 2
Synonyms: Plcg-2, PLCgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Pex14
Name: peroxisomal biogenesis factor 14
Synonyms: Pex14p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56273
HGNC: HGNC:8856
Homologene: 37936
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230082
Homologene: 41505
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Tulip1, 2310003F20Rik, 4930400K19Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Cst9
Name: cystatin 9
Synonyms: cresp, M12, testatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13013
Homologene: 49222
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: C330008N13Rik, 4932415L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319651
Homologene: 10858
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234076
Homologene: 32376
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: TEP, PTPMEG, hPTP-MEG, testis-enriched phosphatase, TEP/mPTPMEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ano4
Name: anoctamin 4
Synonyms: Tmem16d, A330096O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320091
Homologene: 66599
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, 2900022L05Rik, Dnhd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 637515
Homologene: 19080
Ephb2
Name: Eph receptor B2
Synonyms: Prkm5, Nuk, Tyro5, Qek5, Cek5, Sek3, Drt, eteck, Hek5, Erk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Camk2d
Name: calcium/calmodulin-dependent protein kinase II, delta
Synonyms: 2810011D23Rik, CaMK II, 8030469K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108058
HGNC: HGNC:1462
Homologene: 55561
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20271
Homologene: 22738
Rnf135
Name: ring finger protein 135
Synonyms: 2410006N06Rik, 0610037N03Rik, U 2-3-0, MGC13061
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71956
Homologene: 12427
Hcrtr2
Name: hypocretin (orexin) receptor 2
Synonyms: mOXR2, mOX2aR, mOX2bR, OX2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 387285
HGNC: HGNC:4849
Homologene: 1168
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21744
Homologene: 7569
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620928
Homologene: 115466
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329942
Homologene: 89034
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Gucy2e
Name: guanylate cyclase 2e
Synonyms: ROS-GC1, GC1, GC-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: SDCT2, NaDC3, NaDC-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 114644
Homologene: 11266
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, Unc84a, 5730434D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77053
Homologene: 11544
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231861
Homologene: 45603
Akr1c20
Name: aldo-keto reductase family 1, member C20
Synonyms: 2610528B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 116852
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Plxnc1
Name: plexin C1
Synonyms: CD232, vespr, 2510048K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Noxa1
Name: NADPH oxidase activator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241275
Homologene: 18156
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224576
Homologene: 135824
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208372
Homologene: 16382
Cybc1
Name: cytochrome b 245 chaperone 1
Synonyms: BC017643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217370
Homologene: 51645
Nudt6
Name: nudix hydrolase 6
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229228
HGNC: HGNC:8053
Homologene: 31425
Ddah2
Name: DDAH family member 2, ADMA independent
Synonyms: Clone 7u, Ddah, NG30, G6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 51793
HGNC: HGNC:2716
Homologene: 8510
Acyp2
Name: acylphosphatase 2, muscle type
Synonyms: 2310004B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75572
HGNC: HGNC:180
Homologene: 41776
Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Synonyms: C130020P05Rik, 2010205O06Rik, BLOC-3, Hermansky-Pudlak syndrome 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 192232
Homologene: 11123
Defb11
Name: defensin beta 11
Synonyms: Defb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 246081
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,470,626 bp
  • A to C, chromosome 1 at 90,014,538 bp
  • A to T, chromosome 1 at 119,684,516 bp
  • A to C, chromosome 1 at 128,266,321 bp
  • T to A, chromosome 2 at 25,086,241 bp
  • G to A, chromosome 2 at 148,838,473 bp
  • A to G, chromosome 2 at 154,500,455 bp
  • T to C, chromosome 2 at 165,408,956 bp
  • T to C, chromosome 3 at 37,092,109 bp
  • T to C, chromosome 3 at 37,419,468 bp
  • T to C, chromosome 3 at 80,845,142 bp
  • T to C, chromosome 3 at 126,770,886 bp
  • T to A, chromosome 4 at 41,122,158 bp
  • T to C, chromosome 4 at 128,519,199 bp
  • T to A, chromosome 4 at 136,660,737 bp
  • T to C, chromosome 4 at 148,966,279 bp
  • C to T, chromosome 5 at 112,368,854 bp
  • T to G, chromosome 5 at 139,245,416 bp
  • G to A, chromosome 5 at 142,773,747 bp
  • T to C, chromosome 7 at 85,875,748 bp
  • T to C, chromosome 8 at 13,310,314 bp
  • T to C, chromosome 8 at 21,905,494 bp
  • T to C, chromosome 8 at 117,610,844 bp
  • A to C, chromosome 9 at 76,323,287 bp
  • A to G, chromosome 9 at 86,507,570 bp
  • A to G, chromosome 9 at 119,521,333 bp
  • T to A, chromosome 10 at 88,952,327 bp
  • C to T, chromosome 10 at 94,799,473 bp
  • A to G, chromosome 11 at 9,682,056 bp
  • C to T, chromosome 11 at 30,506,354 bp
  • A to G, chromosome 11 at 69,236,033 bp
  • C to T, chromosome 11 at 69,458,920 bp
  • A to T, chromosome 11 at 71,181,196 bp
  • A to T, chromosome 11 at 76,784,416 bp
  • A to T, chromosome 11 at 80,199,086 bp
  • A to T, chromosome 11 at 118,034,367 bp
  • A to G, chromosome 11 at 120,956,930 bp
  • T to A, chromosome 11 at 121,226,892 bp
  • T to G, chromosome 12 at 55,677,113 bp
  • T to C, chromosome 13 at 4,510,223 bp
  • T to A, chromosome 15 at 56,668,102 bp
  • G to A, chromosome 16 at 15,734,098 bp
  • A to T, chromosome 17 at 20,278,871 bp
  • C to A, chromosome 17 at 33,065,314 bp
  • A to G, chromosome 17 at 35,060,688 bp
  • C to T, chromosome 17 at 35,221,165 bp
  • A to T, chromosome 18 at 50,183,172 bp
  • T to A, chromosome 19 at 57,630,292 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5826 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043217-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.