Strain Name:
C57BL/6J-MtgxR5842Btlr/Mmmh
Stock Number:
043223-MU
Citation ID:
RRID:MMRRC_043223-MU
Other Names:
R5842 (G1), C57BL/6J-MtgxR5842Btlr
Major Collection:

Gene Information

Bmp6
Name: bone morphogenetic protein 6
Synonyms: D13Wsu115e, Vgr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 12161
VEGA: 13
HGNC: HGNC:1073
Homologene: 1300
Wdr73
Name: WD repeat domain 73
Synonyms: 2410008B13Rik, 1200011I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71968
Homologene: 41899
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: NBCn1, NBC3, E430014N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218756
VEGA: 14
Homologene: 2680
Srsf11
Name: serine/arginine-rich splicing factor 11
Synonyms: 2610019N13Rik, 0610009J05Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69207
Homologene: 36164
Ppil2
Name: peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms: C130078A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 66053
HGNC: HGNC:9261
Homologene: 8643
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 21853
Homologene: 31206
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, 2900024N03Rik, Mnab, 9430019J22Rik, D930043C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 319817
Homologene: 28276
Polr1c
Name: polymerase (RNA) I polypeptide C
Synonyms: RPA40, Rpo1-1, 40kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20016
Homologene: 3586
Ube4b
Name: ubiquitination factor E4B
Synonyms: 4930551I19Rik, Ufd2p, D4Bwg0973e, UFD2a, UFD2, 4933406G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 63958
Homologene: 107623
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 21844
Homologene: 2443
Mtpn
Name: myotrophin
Synonyms: V1, 5033418D15Rik, Gcdp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14489
Homologene: 40607
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72205
Homologene: 8125
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, ZFYVE2, A430109M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71169
VEGA: 12
Homologene: 41073
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: Atp1al1, cHKA, HKalpha2, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 192113
VEGA: 14
Homologene: 68197
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Nlgn1
Name: neuroligin 1
Synonyms: Nlg1, NL1, 6330415N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192167
Homologene: 56690
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 213262
Homologene: 10584
Enpep
Name: glutamyl aminopeptidase
Synonyms: Ly51, APA, Bp-1/6C3, 6030431M22Rik, aminopeptidase-A, Ly-51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 69239
Homologene: 130756
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Ugcgl, Epcs21, GlcT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22234
Homologene: 37763
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, C330021K24Rik, 5830437M04Rik, Gababrbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76071
Homologene: 90789
Gatm
Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase)
Synonyms: 1810003P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67092
HGNC: HGNC:4175
Homologene: 1136
Olfr508
Name: olfactory receptor 508
Synonyms: GA_x6K02T2PBJ9-10959726-10960658, MOR204-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258769
Homologene: 72039
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 214804
Homologene: 19035
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Rhoc
Name: ras homolog family member C
Synonyms: Arh9, Arhc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11853
HGNC: HGNC:669
Homologene: 90945
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74362
Homologene: 52601
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 80285
Homologene: 12720
Vsig10l
Name: V-set and immunoglobulin domain containing 10 like
Synonyms: 2210412E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75690
Homologene: 35386
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18115
HGNC: HGNC:7863
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Olfr225
Name: olfactory receptor 225
Synonyms: MOR256-51, GA_x6K02T0073K-490-1545
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 257886
Homologene: 105324
Rab12
Name: RAB12, member RAS oncogene family
Synonyms: 2900054P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19328
Homologene: 103879
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: D18Ucla2, Slc23a2, YSPL3, SVCT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20522
Homologene: 40769
Xrcc3
Name: X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms: 4432412E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74335
Homologene: 36178
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71481
Homologene: 11849
Trp53tg5
Name: transformation related protein 53 target 5
Synonyms: 1700126L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73603
Homologene: 49386
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: G[a]h, TG C, TG2, protein-glutamine gamma-glutamyltransferase, tTG, tTGas, tissue transglutaminase, TGase2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21817
Homologene: 3391
Pacc1
Name: proton activated chloride channel 1
Synonyms: Tmem206, 2310028N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66950
Homologene: 10097
Vgll2
Name: vestigial like family member 2
Synonyms: VITO-1, Vgl-2, Vito1, C130057C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215031
Homologene: 35066
Pmvk
Name: phosphomevalonate kinase
Synonyms: 1110011E12Rik, 2900002L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 68603
HGNC: HGNC:9141
Homologene: 4779
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: Gm9813, EG639426, LOC217602, 4921506M07Rik, AU024163
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70846
Homologene: 78002
Pcdha11
Name: protocadherin alpha 11
Synonyms: A830022B16Rik, Crnr7, Cnr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 191,346,789 bp
  • T to C, chromosome 2 at 37,378,371 bp
  • T to C, chromosome 2 at 122,603,627 bp
  • C to T, chromosome 2 at 158,143,081 bp
  • T to C, chromosome 2 at 164,471,369 bp
  • A to T, chromosome 3 at 26,133,743 bp
  • T to G, chromosome 3 at 76,322,283 bp
  • T to A, chromosome 3 at 89,467,620 bp
  • A to G, chromosome 3 at 99,939,250 bp
  • G to A, chromosome 3 at 104,799,379 bp
  • G to A, chromosome 3 at 127,680,969 bp
  • T to C, chromosome 3 at 129,298,904 bp
  • A to G, chromosome 3 at 145,999,020 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • C to T, chromosome 4 at 59,219,545 bp
  • G to T, chromosome 4 at 149,331,430 bp
  • C to T, chromosome 5 at 37,107,268 bp
  • C to T, chromosome 6 at 35,512,290 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to A, chromosome 7 at 43,468,972 bp
  • AGGGCC to A, chromosome 7 at 80,098,341 bp
  • A to T, chromosome 7 at 80,891,710 bp
  • A to G, chromosome 7 at 108,630,652 bp
  • A to G, chromosome 9 at 108,965,815 bp
  • T to C, chromosome 10 at 52,025,292 bp
  • A to G, chromosome 10 at 96,018,124 bp
  • T to C, chromosome 10 at 128,247,459 bp
  • A to G, chromosome 11 at 59,613,965 bp
  • T to C, chromosome 12 at 13,269,266 bp
  • T to C, chromosome 12 at 57,737,016 bp
  • A to T, chromosome 12 at 111,804,530 bp
  • T to A, chromosome 13 at 38,346,567 bp
  • T to A, chromosome 13 at 119,394,747 bp
  • T to A, chromosome 14 at 14,778,866 bp
  • T to C, chromosome 14 at 56,378,290 bp
  • A to T, chromosome 15 at 34,399,056 bp
  • G to A, chromosome 15 at 98,852,109 bp
  • T to C, chromosome 16 at 17,094,987 bp
  • A to G, chromosome 16 at 35,943,408 bp
  • A to G, chromosome 16 at 89,855,999 bp
  • G to T, chromosome 17 at 46,247,709 bp
  • T to G, chromosome 17 at 58,974,412 bp
  • T to C, chromosome 17 at 66,505,017 bp
  • T to A, chromosome 18 at 35,622,882 bp
  • T to A, chromosome 18 at 37,011,284 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5842 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043223-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.