Strain Name:
C57BL/6J-MtgxR5843Btlr/Mmmh
Stock Number:
043224-MU
Citation ID:
RRID:MMRRC_043224-MU
Other Names:
R5843 (G1), C57BL/6J-MtgxR5843Btlr
Major Collection:

Gene Information

Hpcal1
Name: hippocalcin-like 1
Synonyms: neural visinin-like 3, VILIP3, visinin like 3, Vnsl3, Nvp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 53602
VEGA: 12
HGNC: HGNC:5145
Homologene: 37586
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Centg2, Ggap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 347722
Homologene: 56689
Atp6v1h
Name: ATPase, H+ transporting, lysosomal V1 subunit H
Synonyms: 0710001F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108664
Homologene: 7139
Arl5b
Name: ADP-ribosylation factor-like 5B
Synonyms: Arl8, 4930587A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 75869
Homologene: 101695
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 21853
Homologene: 31206
Orc2
Name: origin recognition complex, subunit 2
Synonyms: Orc2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18393
HGNC: HGNC:8488
Homologene: 4512
Ccnk
Name: cyclin K
Synonyms: CPR4, CycK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 12454
VEGA: 12
HGNC: HGNC:1596
Homologene: 14748
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, eyes2, crf11, QBRICK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329872
Homologene: 27049
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 117146
Homologene: 13775
Rbm39
Name: RNA binding motif protein 39
Synonyms: Caper alpha, 2310040E03Rik, B330012G18Rik, 1500012C14Rik, Rnpc2, caper
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 170791
Homologene: 136465
Creld2
Name: cysteine-rich with EGF-like domains 2
Synonyms: 5730592L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 76737
VEGA: 15
Homologene: 11526
Mtpn
Name: myotrophin
Synonyms: V1, 5033418D15Rik, Gcdp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14489
Homologene: 40607
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: 2210409B11Rik, LOC385628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 70144
Homologene: 13111
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72205
Homologene: 8125
Wnt16
Name: wingless-type MMTV integration site family, member 16
Synonyms: E130309I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 93735
Homologene: 62175
Chn1
Name: chimerin 1
Synonyms: alpha1 chimaerin, alpha2 chimaerin, 1700112L09Rik, 0710001E19Rik, 2900046J01Rik, ARHGAP2, 0610007I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108699
HGNC: HGNC:1943
Homologene: 31056
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225997
VEGA: 19
Homologene: 9767
Zim1
Name: zinc finger, imprinted 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22776
Homologene: 129793
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, myomaxin, Cmya3, 2310008C07Rik, mXin beta, 2310003D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241431
Homologene: 19388
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208795
Homologene: 101673
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244871
VEGA: 9
Homologene: 35462
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, C030048J01Rik, Lba1, LOC235639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320429
Homologene: 45845
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19886
Homologene: 2207
Olfr169
Name: olfactory receptor 169
Synonyms: MOR273-3P, GA_x54KRFPKG5P-16014972-16014031
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258158
Homologene: 128058
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: FIST3, DYRK6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Parpbp
Name: PARP1 binding protein
Synonyms: 4930547N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 75317
Homologene: 49519
Zfp651
Name: zinc finger protein 651
Synonyms: 4732420M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270210
VEGA: 9
Homologene: 136302
Tas2r104
Name: taste receptor, type 2, member 104
Synonyms: mt2r45, Tas2r4, T2R04, mGR04
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387340
Homologene: 130072
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 170833
Homologene: 8332
Cdh10
Name: cadherin 10
Synonyms: C030003B10Rik, T2-cadherin, A830016G23Rik, C030011H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320873
HGNC: HGNC:1749
Homologene: 68530
Klhdc8b
Name: kelch domain containing 8B
Synonyms: 4931406O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78267
Homologene: 45463
Olfr10
Name: olfactory receptor 10
Synonyms: MOR256-55, GA_x6K02T2QP88-6117098-6116163, L45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18307
Homologene: 81347
Zfp865
Name: zinc finger protein 865
Synonyms: 6430526N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 319748
Homologene: 19652
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22033
Homologene: 27079
Muc13
Name: mucin 13, epithelial transmembrane
Synonyms: Ly64, 114/A10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17063
HGNC: HGNC:7511
Homologene: 7822
Olfr203
Name: olfactory receptor 203
Synonyms: MOR182-5, GA_x54KRFPKG5P-55517445-55518365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258479
Homologene: 122781
Sept8
Name: septin 8
Synonyms: Sepl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20362
Homologene: 57205
Prl3a1
Name: prolactin family 3, subfamily a, member 1
Synonyms: PLP-I, Prlpi, PLP-H, Plpi, 1600016E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67000
Homologene: 49844
Khk
Name: ketohexokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16548
HGNC: HGNC:6315
Homologene: 38187
Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Synonyms: BLOC-3, C130020P05Rik, 2010205O06Rik, Hermansky-Pudlak syndrome 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 192232
Homologene: 11123
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71706
Homologene: 41733
Olfr367-ps
Name: olfactory receptor 367, pseudogene
Synonyms: EG545417, GA_x6K02T2NLDC-33954853-33955794, MOR128-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545417
Homologene: 129598
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 5,162,089 bp
  • T to C, chromosome 1 at 58,481,020 bp
  • A to G, chromosome 1 at 89,609,550 bp
  • T to C, chromosome 1 at 180,972,833 bp
  • T to C, chromosome 1 at 191,997,485 bp
  • A to C, chromosome 2 at 15,070,002 bp
  • A to T, chromosome 2 at 37,271,221 bp
  • G to T, chromosome 2 at 67,476,785 bp
  • A to G, chromosome 2 at 73,679,748 bp
  • A to C, chromosome 2 at 104,440,224 bp
  • A to T, chromosome 2 at 156,162,873 bp
  • T to C, chromosome 4 at 82,936,052 bp
  • A to G, chromosome 5 at 30,921,931 bp
  • T to C, chromosome 5 at 112,349,430 bp
  • T to A, chromosome 5 at 114,412,299 bp
  • T to C, chromosome 5 at 147,886,211 bp
  • T to A, chromosome 6 at 22,290,948 bp
  • C to T, chromosome 6 at 35,512,290 bp
  • T to A, chromosome 6 at 131,684,975 bp
  • C to A, chromosome 7 at 5,030,417 bp
  • A to G, chromosome 7 at 6,677,698 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to C, chromosome 7 at 80,726,080 bp
  • TTCCTC to TTC, chromosome 7 at 119,951,021 bp
  • T to A, chromosome 8 at 84,991,283 bp
  • G to T, chromosome 9 at 52,116,682 bp
  • C to A, chromosome 9 at 108,449,806 bp
  • C to T, chromosome 9 at 111,365,860 bp
  • T to C, chromosome 9 at 121,767,339 bp
  • T to A, chromosome 10 at 28,493,064 bp
  • T to C, chromosome 10 at 52,166,197 bp
  • A to G, chromosome 10 at 88,133,191 bp
  • A to G, chromosome 10 at 128,244,244 bp
  • A to T, chromosome 11 at 49,318,249 bp
  • C to T, chromosome 11 at 53,536,076 bp
  • T to C, chromosome 12 at 17,791,199 bp
  • T to C, chromosome 12 at 108,193,730 bp
  • T to C, chromosome 13 at 27,270,110 bp
  • T to C, chromosome 15 at 18,985,200 bp
  • A to T, chromosome 15 at 88,826,429 bp
  • G to A, chromosome 15 at 98,852,109 bp
  • T to A, chromosome 16 at 19,566,583 bp
  • T to C, chromosome 16 at 32,998,526 bp
  • A to G, chromosome 16 at 33,806,051 bp
  • T to A, chromosome 16 at 59,303,361 bp
  • A to G, chromosome 19 at 18,856,175 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5843 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043224-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.