Strain Name:
C57BL/6J-MtgxR5848Btlr/Mmmh
Stock Number:
043225-MU
Citation ID:
RRID:MMRRC_043225-MU
Other Names:
R5848 (G1), C57BL/6J-MtgxR5848Btlr
Major Collection:

Gene Information

Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233765
Homologene: 52172
Eif4a2
Name: eukaryotic translation initiation factor 4A2
Synonyms: Eif4, 4833432N07Rik, BM-010, Ddx2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13682
HGNC: HGNC:3284
Homologene: 1487
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: KAT, 2410003J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Xpo6
Name: exportin 6
Synonyms: Ranbp20, C230091E20Rik, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18140
Homologene: 7866
Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Synonyms: Zpk, DLK, MUK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26404
HGNC: HGNC:6851
Homologene: 4592
Pgr
Name: progesterone receptor
Synonyms: NR3C3, PR, 9930019P03Rik, PR-B, PR-A, ENSMUSG00000074510
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109332
Homologene: 11276
Clec18a
Name: C-type lectin domain family 18, member A
Synonyms: Mrcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353287
Homologene: 18755
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 5730419H05Rik, 1200013I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74132
Homologene: 14036
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: CLIMP-63, P63, 5630400A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216197
VEGA: 10
Homologene: 4970
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435815
Homologene: 82530
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231238
Homologene: 9054
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
4930553M12Rik
Name: RIKEN cDNA 4930553M12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Or5e1
Name: olfactory receptor family 5 subfamily E member 1
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1, Olfr513
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258718
Homologene: 64908
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Napg
Name: N-ethylmaleimide sensitive fusion protein attachment protein gamma
Synonyms: SNARE, 2400003O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108123
HGNC: HGNC:7642
Homologene: 2838
Mmp11
Name: matrix metallopeptidase 11
Synonyms: stromelysin 3, ST3, Stmy3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17385
HGNC: HGNC:7157
Homologene: 38116
Gm10644
Name: predicted gene 10644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100126034
VEGA: 8
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71007
Homologene: 18998
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64451
Homologene: 41012
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Mks1
Name: MKS transition zone complex subunit 1
Synonyms: B8d3, avc6, Meckel syndrome, type 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380718
HGNC: HGNC:7121
Homologene: 9833
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: 4831416G18Rik, Sh3md4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237353
Homologene: 77551
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: PSD93, Chapsyn-110, A330103J02Rik, B330007M19Rik, LOC382816, Dlgh2, B230218P12Rik, Gm21505
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
P3r3urf
Name: Pik3r3 upstream reading frame
Synonyms: 1700042G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67323
Homologene: 135820
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, MOR118-1, GA_x6K02T2QVSB-39745261-39746202, Olfr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18348
Homologene: 106373
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12939
Homologene: 117962
Fer1l5
Name: fer-1-like 5 (C. elegans)
Synonyms: 4930533C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,388,935 bp
  • T to C, chromosome 2 at 76,763,338 bp
  • A to G, chromosome 2 at 76,780,920 bp
  • A to C, chromosome 2 at 76,878,564 bp
  • T to C, chromosome 4 at 88,868,359 bp
  • T to C, chromosome 4 at 116,173,615 bp
  • T to A, chromosome 4 at 144,617,858 bp
  • A to C, chromosome 5 at 53,184,808 bp
  • G to A, chromosome 5 at 146,211,149 bp
  • A to T, chromosome 6 at 12,503,923 bp
  • T to G, chromosome 7 at 92,444,527 bp
  • T to A, chromosome 7 at 108,755,574 bp
  • T to C, chromosome 7 at 116,140,399 bp
  • T to C, chromosome 7 at 126,110,047 bp
  • A to G, chromosome 7 at 134,349,722 bp
  • C to A, chromosome 8 at 83,934,039 bp
  • A to G, chromosome 8 at 95,098,712 bp
  • C to T, chromosome 8 at 111,075,461 bp
  • T to C, chromosome 9 at 8,900,668 bp
  • T to A, chromosome 9 at 123,183,705 bp
  • T to A, chromosome 10 at 58,984,153 bp
  • T to C, chromosome 10 at 75,927,389 bp
  • G to A, chromosome 10 at 76,273,062 bp
  • T to C, chromosome 10 at 84,533,490 bp
  • A to G, chromosome 11 at 87,856,870 bp
  • C to A, chromosome 11 at 109,977,813 bp
  • A to G, chromosome 13 at 48,820,070 bp
  • A to G, chromosome 14 at 54,282,565 bp
  • G to A, chromosome 15 at 6,794,006 bp
  • A to G, chromosome 15 at 102,504,235 bp
  • T to C, chromosome 16 at 23,112,295 bp
  • T to C, chromosome 17 at 30,728,191 bp
  • T to C, chromosome 17 at 46,956,655 bp
  • T to A, chromosome 17 at 56,312,873 bp
  • T to A, chromosome 18 at 7,268,507 bp
  • G to T, chromosome 18 at 36,975,083 bp
  • G to T, chromosome 18 at 37,301,647 bp
  • A to G, chromosome 18 at 62,994,369 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5848 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043225-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.