Strain Name:
C57BL/6J-MtgxR5885Btlr/Mmmh
Stock Number:
043237-MU
Citation ID:
RRID:MMRRC_043237-MU
Other Names:
R5885 (G1), C57BL/6J-MtgxR5885Btlr
Major Collection:

Gene Information

Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap5, Mtap-5, MAP5, Mtap1b, LC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Fbxl3
Name: F-box and leucine-rich repeat protein 3
Synonyms: Play68, Fbxl3a, Fbl3a, Ovtm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50789
Homologene: 8127
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17776
Homologene: 7428
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100683
Homologene: 39246
Myo9a
Name: myosin IXa
Synonyms: C130068I12Rik, 4732465J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: Lyt-4, CD45, Ly-5, T200, B220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Ctsa
Name: cathepsin A
Synonyms: Ppgb, PPCA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19025
HGNC: HGNC:9251
Homologene: 80163
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: NFAT4, D8Ertd281e, NFATx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: Plod-2, lysyl hydroxylase 2, LH2, D530025C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 27215
Homologene: 8443
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 109242
Homologene: 52346
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72946
Homologene: 10795
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74552
Homologene: 10722
Tyw3
Name: tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
Synonyms: 5230400J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 209584
Homologene: 44531
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: Flk2, wmfl, Flt-3, CD135, Flk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Sv2b
Name: synaptic vesicle glycoprotein 2 b
Synonyms: A830038F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 64176
Homologene: 32236
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11982
Homologene: 56461
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: A230104H11Rik, 2810022L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67198
Homologene: 56711
Khdrbs3
Name: KH domain containing, RNA binding, signal transduction associated 3
Synonyms: SLM-2, Etle, T-STAR, Salp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13992
VEGA: 15
Homologene: 4780
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mgr1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: Spnb5, EG640524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 640524
Homologene: 41150
Acot10
Name: acyl-CoA thioesterase 10
Synonyms: MT-ACT48, Acate3, p48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 64833
VEGA: 15
Homologene: 8206
Dnase1l2
Name: deoxyribonuclease 1-like 2
Synonyms: 4733401H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 66705
HGNC: HGNC:2958
Homologene: 74391
Epas1
Name: endothelial PAS domain protein 1
Synonyms: bHLHe73, HIF2A, HLF, MOP2, HRF, HIF-2alpha, hypoxia inducible transcription factor 2alpha, Hif like protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: GluN2A, NMDAR2A, GluRepsilon1, NR2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Slc2a9
Name: solute carrier family 2 (facilitated glucose transporter), member 9
Synonyms: Glut9, SLC2A9B, SLC2a9A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 117591
Homologene: 69290
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Ufo, Ark, Tyro7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219149
Homologene: 18287
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 382407
VEGA: 10
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 209966
Homologene: 11583
Gpr141b
Name: G protein-coupled receptor 141B
Synonyms: A530099J19Rik, Karma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 319293
Homologene: 105930
Fgf12
Name: fibroblast growth factor 12
Synonyms: Fhf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14167
VEGA: 16
HGNC: HGNC:3668
Homologene: 10874
Psg27
Name: pregnancy-specific glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545925
Homologene: 110989
Psg22
Name: pregnancy-specific glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243862
Homologene: 110989
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627367
Homologene: 115024
Fam47e
Name: family with sequence similarity 47, member E
Synonyms: LOC384198, Gm1381
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384198
Homologene: 129958
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 1500000C01Rik, D11Ertd636e, 0610010C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 52670
Homologene: 32669
Tas2r121
Name: taste receptor, type 2, member 121
Synonyms: Tas2r21, T2R21, mGR21, mT2r48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387349
Homologene: 41542
Stox1
Name: storkhead box 1
Synonyms: 4732470K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216021
Homologene: 17649
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: 2300001H05Rik, CYSLT2R, Cyslt2, CysLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70086
VEGA: 14
Homologene: 10688
Ifna4
Name: interferon alpha 4
Synonyms: Ifa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15967
Fcgr3
Name: Fc receptor, IgG, low affinity III
Synonyms: FcgammaRIII, CD16, Fcg receptor III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14131
HGNC: HGNC:3616
Homologene: 47936
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 57,946,162 bp
  • T to A, chromosome 1 at 138,088,508 bp
  • A to G, chromosome 1 at 171,057,711 bp
  • A to G, chromosome 2 at 120,076,663 bp
  • T to C, chromosome 2 at 164,832,891 bp
  • G to T, chromosome 2 at 180,201,831 bp
  • A to G, chromosome 3 at 154,580,105 bp
  • A to T, chromosome 4 at 41,423,463 bp
  • T to A, chromosome 4 at 88,842,362 bp
  • C to T, chromosome 4 at 116,314,838 bp
  • A to T, chromosome 4 at 135,471,977 bp
  • T to A, chromosome 4 at 154,015,972 bp
  • G to A, chromosome 5 at 38,440,674 bp
  • A to G, chromosome 5 at 92,565,968 bp
  • T to A, chromosome 5 at 144,794,793 bp
  • T to C, chromosome 5 at 147,349,629 bp
  • T to G, chromosome 6 at 132,700,291 bp
  • T to A, chromosome 7 at 18,561,786 bp
  • T to A, chromosome 7 at 18,718,332 bp
  • T to A, chromosome 7 at 25,766,852 bp
  • T to A, chromosome 7 at 58,813,800 bp
  • C to T, chromosome 7 at 75,156,753 bp
  • A to G, chromosome 8 at 106,096,312 bp
  • G to A, chromosome 8 at 124,384,466 bp
  • T to C, chromosome 9 at 59,871,220 bp
  • A to G, chromosome 9 at 62,762,850 bp
  • T to A, chromosome 9 at 92,606,656 bp
  • T to A, chromosome 9 at 118,047,560 bp
  • C to A, chromosome 10 at 62,664,848 bp
  • G to A, chromosome 10 at 99,445,147 bp
  • T to A, chromosome 11 at 113,703,191 bp
  • G to T, chromosome 12 at 38,781,347 bp
  • A to T, chromosome 13 at 19,729,349 bp
  • A to T, chromosome 13 at 81,424,271 bp
  • A to T, chromosome 13 at 99,430,081 bp
  • T to A, chromosome 14 at 63,606,911 bp
  • T to C, chromosome 14 at 73,029,491 bp
  • A to T, chromosome 14 at 103,083,231 bp
  • T to C, chromosome 15 at 10,488,057 bp
  • T to A, chromosome 15 at 20,666,104 bp
  • A to G, chromosome 15 at 69,024,698 bp
  • A to G, chromosome 16 at 9,761,905 bp
  • G to T, chromosome 16 at 28,398,294 bp
  • A to G, chromosome 17 at 18,947,773 bp
  • G to A, chromosome 17 at 24,441,529 bp
  • C to T, chromosome 17 at 30,794,717 bp
  • A to G, chromosome 17 at 86,827,544 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5885 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043237-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.