Strain Name:
C57BL/6J-MtgxR5953Btlr/Mmmh
Stock Number:
043245-MU
Citation ID:
RRID:MMRRC_043245-MU
Other Names:
R5953 (G1), C57BL/6J-MtgxR5953Btlr
Major Collection:

Gene Information

Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235504
Homologene: 56571
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Cenpp
Name: centromere protein P
Synonyms: 4921518G09Rik, 1700022C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66336
VEGA: 13
Homologene: 23543
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12808
Homologene: 9058
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230393
Homologene: 9842
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: rapsyn, Raps, 43kDa acetylcholine receptor-associated protein, Nraps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, C330021I08Rik, C030032G03Rik, VACM-1, 8430423K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Emc7
Name: ER membrane protein complex subunit 7
Synonyms: 2900064A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73024
Homologene: 10597
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Strip2
Name: striatin interacting protein 2
Synonyms: D330017J20Rik, Fam40b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320609
Homologene: 66198
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: NALP3, Pypaf1, Cias1, Mmig1, cryopyrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216799
Homologene: 3600
Elac2
Name: elaC ribonuclease Z 2
Synonyms: 1110017O07Rik, D11Wsu80e, tRNase Z(L)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68626
Homologene: 6403
Snx9
Name: sorting nexin 9
Synonyms: SH3PX1, SDP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66616
VEGA: 17
Homologene: 49454
Plekhm3
Name: pleckstrin homology domain containing, family M, member 3
Synonyms: A230102O09Rik, Plekhm1l, 9430067K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241075
Homologene: 18459
Cd209d
Name: CD209d antigen
Synonyms: SIGNR3, mSIGNR3, SIGN-R3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170779
HGNC: HGNC:1641
Homologene: 8603
Il1rl1
Name: interleukin 1 receptor-like 1
Synonyms: T1 gene, T1, ST2, T1/ST2, Fit-1, DER4, ST2L, St2, St2-rs1, Ly84
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17082
HGNC: HGNC:5998
Homologene: 2862
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Intu
Name: inturned planar cell polarity protein
Synonyms: 9430087H23Rik, 9230116I04Rik, Pdzk6, Pdzd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 380614
Homologene: 41059
Tbc1d20
Name: TBC1 domain family, member 20
Synonyms: 1110028I04Rik, 2810442O16Rik, bs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67231
Homologene: 32574
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Asns
Name: asparagine synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Clec4a3
Name: C-type lectin domain family 4, member a3
Synonyms: 3110037K17Rik, mDcir3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73149
Homologene: 9413
Pglyrp1
Name: peptidoglycan recognition protein 1
Synonyms: Tag7, peptidoglycan recognition protein, Tasg7, Tnfsf3l, PGRP-S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21946
HGNC: HGNC:8904
Homologene: 74539
Gata3
Name: GATA binding protein 3
Synonyms: Gata-3, jal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74525
Homologene: 12572
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 29807
Homologene: 6960
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338349
Homologene: 9805
Olfr1474
Name: olfactory receptor 1474
Synonyms: GA_x6K02T2RE5P-3803583-3804527, MOR202-26P, MOR202-42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258123
Homologene: 79417
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl, thrombopoietin receptor, TPO-R, CD110, c-mpl-II, c-mpl-I, hlb219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Meis2
Name: Meis homeobox 2
Synonyms: Meis2, Stra10, A430109D20Rik, Mrg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Eya4
Name: EYA transcriptional coactivator and phosphatase 4
Synonyms: B130023L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14051
VEGA: 10
HGNC: HGNC:3522
Homologene: 3025
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: PGR20, Gpr111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 435529
Homologene: 45213
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: CD122, Il-2Rbeta, IL15Rbeta, IL-2/15Rbeta, IL-15 receptor beta chain, IL-15Rbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Trem1
Name: triggering receptor expressed on myeloid cells 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58217
Homologene: 10243
Adamts14
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237360
Homologene: 16383
Fam217b
Name: family with sequence similarity 217, member B
Synonyms: 9030418K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71532
Homologene: 49697
Pomk
Name: protein-O-mannose kinase
Synonyms: Sgk196, 4930444A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74653
Homologene: 12580
Cenps
Name: centromere protein S
Synonyms: 2810407L01Rik, 2610040C18Rik, Apitd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69928
Homologene: 66004
Cym
Name: chymosin
Synonyms: LOC229697, Gm131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229697
Homologene: 129841
Olfr812
Name: olfactory receptor 812
Synonyms: GA_x6K02T2PULF-11521598-11520666, MOR110-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258791
Homologene: 73931
S100a9
Name: S100 calcium binding protein A9 (calgranulin B)
Synonyms: MRP14, Cagb, BEE22, 60B8Ag, GAGB, L1Ag, p14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20202
Homologene: 2227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,442,673 bp
  • C to T, chromosome 1 at 64,937,895 bp
  • C to T, chromosome 2 at 9,863,188 bp
  • T to C, chromosome 2 at 48,890,404 bp
  • T to C, chromosome 2 at 91,041,963 bp
  • T to A, chromosome 2 at 112,459,558 bp
  • T to C, chromosome 2 at 115,864,225 bp
  • T to A, chromosome 2 at 152,308,187 bp
  • C to T, chromosome 2 at 178,420,360 bp
  • A to C, chromosome 3 at 40,679,550 bp
  • T to A, chromosome 3 at 90,692,927 bp
  • T to A, chromosome 3 at 107,213,467 bp
  • C to T, chromosome 4 at 85,049,919 bp
  • A to G, chromosome 4 at 88,229,335 bp
  • C to A, chromosome 4 at 118,454,510 bp
  • T to A, chromosome 4 at 118,454,511 bp
  • A to G, chromosome 4 at 131,776,837 bp
  • C to A, chromosome 4 at 149,130,201 bp
  • T to C, chromosome 6 at 7,682,285 bp
  • T to A, chromosome 6 at 29,924,976 bp
  • G to A, chromosome 6 at 43,665,859 bp
  • G to T, chromosome 6 at 122,969,492 bp
  • G to T, chromosome 6 at 135,225,707 bp
  • A to T, chromosome 7 at 18,890,313 bp
  • T to A, chromosome 7 at 120,361,018 bp
  • G to T, chromosome 7 at 141,701,382 bp
  • A to T, chromosome 8 at 3,877,979 bp
  • C to A, chromosome 8 at 25,983,048 bp
  • A to G, chromosome 9 at 53,617,936 bp
  • T to C, chromosome 9 at 78,557,498 bp
  • T to A, chromosome 10 at 23,151,973 bp
  • T to C, chromosome 10 at 61,207,446 bp
  • C to G, chromosome 10 at 129,842,614 bp
  • T to A, chromosome 11 at 12,256,220 bp
  • C to T, chromosome 11 at 59,546,791 bp
  • G to A, chromosome 11 at 64,999,223 bp
  • A to T, chromosome 11 at 69,354,323 bp
  • A to G, chromosome 11 at 113,793,744 bp
  • T to C, chromosome 12 at 70,219,627 bp
  • T to C, chromosome 13 at 49,652,685 bp
  • G to A, chromosome 13 at 93,499,116 bp
  • A to T, chromosome 15 at 78,484,982 bp
  • A to T, chromosome 16 at 17,281,951 bp
  • T to A, chromosome 17 at 5,908,402 bp
  • G to T, chromosome 17 at 5,908,403 bp
  • T to C, chromosome 17 at 42,710,338 bp
  • A to T, chromosome 17 at 48,237,192 bp
  • A to T, chromosome 19 at 13,471,368 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5953 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043245-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.