Strain Name:
C57BL/6J-MtgxR6015Btlr/Mmmh
Stock Number:
043254-MU
Citation ID:
RRID:MMRRC_043254-MU
Other Names:
R6015 (G1), C57BL/6J-MtgxR6015Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: C030027L06Rik, trkB, Tkrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 214572
Homologene: 10382
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hbo1, Myst2, Hboa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217127
Homologene: 5134
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227446
Homologene: 10834
Atxn2
Name: ataxin 2
Synonyms: 9630045M23Rik, ATX2, Sca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20239
Homologene: 2234
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: C130039F11Rik, enaptin165, SYNE-1, A330049M09Rik, nesprin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Aqr
Name: aquarius
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11834
Homologene: 7629
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: HO57, Atp6b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233878
Homologene: 8237
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Inpp5b
Name: inositol polyphosphate-5-phosphatase B
Synonyms: 75kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16330
HGNC: HGNC:6077
Homologene: 69021
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233979
Homologene: 16375
Pik3ap1
Name: phosphoinositide-3-kinase adaptor protein 1
Synonyms: BCAP, 1810044J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83490
VEGA: 19
Homologene: 12848
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: mdfw, USH1D, ahl, nmf252, nmf181, nmf112, sals, bob, 4930542A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: 9230110L08Rik, Rgnef, RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, p190RhoGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Ces1h
Name: carboxylesterase 1H
Synonyms: 2310039D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75704
HGNC: HGNC:1863
Homologene: 119757
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22249
Homologene: 31376
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, 9430076A06Rik, D430038H04Rik, LOC382129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Parp3
Name: poly (ADP-ribose) polymerase family, member 3
Synonyms: PARP-3, Adprt3, A930002C11Rik, Adprtl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235587
HGNC: HGNC:273
Homologene: 4005
Sema4f
Name: sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms: Sema W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20355
Homologene: 3147
Moxd2
Name: monooxygenase, DBH-like 2
Synonyms: Dbhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194357
Homologene: 77226
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94229
Homologene: 23340
Ogfr
Name: opioid growth factor receptor
Synonyms: 2010013E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72075
Homologene: 7199
Ppp1r3c
Name: protein phosphatase 1, regulatory subunit 3C
Synonyms: PTG, protein targeting to glicogen, Ppp1r5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 53412
VEGA: 19
HGNC: HGNC:9293
Homologene: 3938
Psapl1
Name: prosaposin-like 1
Synonyms: 2310020A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76943
Homologene: 105928
Pifo
Name: primary cilia formation
Synonyms: pitchfork, 1700027A23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100503311
Homologene: 18759
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628580
Homologene: 120153
Ssbp2
Name: single-stranded DNA binding protein 2
Synonyms: A830008M03Rik, 1500004K09Rik, Hspc116, 2310079I02Rik, 9330163K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66970
Homologene: 22724
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22404
Homologene: 7997
Ano5
Name: anoctamin 5
Synonyms: Gdd1, Tmem16e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233246
Homologene: 100071
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: Nhe9, 5730527A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 331004
Homologene: 69753
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: C130030K03Rik, Glurbeta2, Glur-6, Glur6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Olfr655
Name: olfactory receptor 655
Synonyms: GA_x6K02T2PBJ9-7224628-7223702, MOR38-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258817
Homologene: 17403
Vmn1r40
Name: vomeronasal 1 receptor 40
Synonyms: V1rb7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113855
Homologene: 113975
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: PI13, HURPIN, headpin, HUR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: uPFK-2, E330010H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Rpp14
Name: ribonuclease P 14 subunit
Synonyms: 2610511E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67053
Homologene: 5113
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: Fim-2, Fim2, M-CSFR, Csfmr, Fms, CSF-1R, CD115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Il9r
Name: interleukin 9 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16199
HGNC: HGNC:6030
Homologene: 37591
Sord
Name: sorbitol dehydrogenase
Synonyms: Sdh1, Sodh-1, Sdh-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20322
Homologene: 56080
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 105,691,958 bp
  • C to A, chromosome 1 at 107,000,607 bp
  • T to C, chromosome 1 at 130,847,261 bp
  • T to C, chromosome 2 at 11,481,335 bp
  • T to A, chromosome 2 at 62,228,702 bp
  • A to G, chromosome 2 at 114,175,165 bp
  • T to C, chromosome 2 at 122,256,943 bp
  • A to G, chromosome 2 at 180,185,392 bp
  • G to T, chromosome 2 at 180,594,674 bp
  • T to C, chromosome 3 at 105,999,621 bp
  • C to A, chromosome 4 at 43,177,995 bp
  • T to C, chromosome 4 at 124,798,350 bp
  • T to C, chromosome 5 at 36,204,250 bp
  • T to A, chromosome 5 at 121,810,992 bp
  • A to T, chromosome 6 at 40,883,754 bp
  • A to G, chromosome 6 at 82,939,572 bp
  • C to A, chromosome 6 at 89,714,606 bp
  • C to T, chromosome 7 at 10,527,689 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to C, chromosome 7 at 51,574,777 bp
  • G to T, chromosome 7 at 104,596,708 bp
  • A to T, chromosome 7 at 126,953,453 bp
  • A to G, chromosome 7 at 145,266,851 bp
  • T to A, chromosome 8 at 69,102,496 bp
  • A to G, chromosome 8 at 93,357,063 bp
  • T to G, chromosome 8 at 106,235,008 bp
  • A to G, chromosome 9 at 16,376,050 bp
  • G to T, chromosome 9 at 94,939,549 bp
  • C to T, chromosome 9 at 106,474,282 bp
  • A to G, chromosome 10 at 5,346,819 bp
  • T to A, chromosome 10 at 12,478,424 bp
  • A to T, chromosome 10 at 49,523,863 bp
  • A to C, chromosome 10 at 60,307,982 bp
  • G to T, chromosome 10 at 86,938,042 bp
  • A to G, chromosome 11 at 32,192,674 bp
  • G to A, chromosome 11 at 95,284,034 bp
  • A to T, chromosome 13 at 59,060,395 bp
  • G to T, chromosome 13 at 91,669,743 bp
  • A to G, chromosome 13 at 98,075,022 bp
  • G to A, chromosome 14 at 8,090,462 bp
  • T to A, chromosome 17 at 32,387,600 bp
  • A to G, chromosome 18 at 57,253,028 bp
  • A to G, chromosome 18 at 61,109,712 bp
  • A to T, chromosome 19 at 36,733,806 bp
  • T to A, chromosome 19 at 41,328,201 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6015 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043254-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.